Labdanum Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Labdanum interacts with medications. The heart of this page is the interaction list — every drug Labdanum is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Labdanum is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Labdanum against your medication
Add one medicationDrugs that interact with Labdanum
0 medications have a known interaction with Labdanum, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Labdanum. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Labdanum combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Labdanum: Uses, Safety & Side Effects
Labdanum is a sticky, fragrant resin from the rockrose plant (Cistus ladanifer) that is used mainly in perfumes, incense, and aromatherapy. There is very little high-quality human research to support any health or medicinal use, so it should be viewed as a scent and cosmetic ingredient rather than a proven remedy.
- Scientific name
- Cistus ladanifer
- Family
- Cistaceae
- Part used
- Sticky resin (oleoresin) and essential oil from the leaves and stems
- Common forms
- Essential oil, absolute, resin (used in perfumes and incense), and occasionally in skin-care products
- Fragrance and perfumery
- Skin care
- Incense and aromatherapy
- Traditional wound and skin remedies
- Relaxation and stress relief
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally used topically or for fragrance; safety as an internal supplement is not well studied.
There is insufficient reliable information available about the safety of labdanum when used in medicinal amounts. Avoid using amounts greater than tho...
Read the full pregnancy detailThere is insufficient reliable information available about the safety of labdanum when used in medicinal amounts. Avoid using amounts greater than tho...
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Labdanum is a sticky, dark, sweet-smelling resin that comes from rockrose shrubs, mainly Cistus ladanifer. These plants grow wild in dry, sunny areas around the Mediterranean, such as Spain, Portugal, and parts of North Africa.
In hot weather, the leaves and stems of the plant ooze a gummy substance. People traditionally collected this resin by combing it from the plants or from the wool of grazing animals. Today it is usually gathered by boiling plant material and skimming off the resin.
Labdanum is best known in perfumery, where it adds a warm, amber-like, leathery scent. It is also used in incense and aromatherapy, and shows up in some skin-care and cosmetic products.
How it works
Labdanum resin contains many natural compounds, including labdane diterpenes (which give it its name), aromatic resins, and small amounts of essential-oil components. These chemicals create its distinctive amber-like scent.
In laboratory and animal studies, extracts of Cistus plants have shown antioxidant and antimicrobial activity, meaning they may slow certain bacteria or fungi and reduce oxidative stress in test conditions. It is important to understand that these are early, non-human findings.
How (or whether) these effects translate into real benefits in the human body is not well understood, and no clear medical mechanism has been confirmed in people.
Does Labdanum work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Labdanum, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Upper respiratory tract infection (URTI)
Preliminary clinical research in adults with URTIs shows that taking lozenges containing a specific extract of Cistus creticus (Cystus052, Dr. Pandalis Urheimische Medizin GMBH & Co.) reduces overall symptoms by an additional 30% when compared with placebo. The infectious agents in this study included influenza A, influenza B, other viruses, Staphylococcus aureus, Streptococcus pneumoniae, Mycoplasma pneumoniae, Chlamydia pneumoniae, and Haemophilus influenzae. Patients with viral infections experienced a more dramatic improvement in symptoms than those with bacterial infections.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
Labdanum is most commonly used externally or for fragrance, and it is widely used in perfumes and cosmetics. Its safety when taken by mouth as a supplement has not been well studied.
As with many essential oils and resins, the concentrated oil should not be swallowed and should be diluted before being applied to the skin. People with sensitive skin or fragrance allergies may react to it.
Pregnancy and breastfeeding: There is not enough reliable information to know if labdanum is safe during pregnancy or while breastfeeding. To be safe, it is best to avoid using it during these times, except possibly as a finished, properly regulated cosmetic or perfume.
Children, and people with chronic medical conditions, should talk to a doctor or pharmacist before using labdanum products for any health purpose.
Side effects
When used in perfumes and cosmetics, labdanum is generally well tolerated by most people. The most common problems are skin reactions, such as irritation, redness, or allergic contact dermatitis, especially in those sensitive to fragrances.
Concentrated essential oils can be irritating if applied undiluted or near the eyes. Swallowing essential oils can cause stomach upset and other problems and is not recommended.
Serious reactions are rare, but if you notice a rash, swelling, trouble breathing, or other signs of an allergic reaction, stop using it and seek medical care.
Labdanum: Reported Adverse Effects
Documented safety reports on Labdanum from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
There is currently a limited amount of information on the adverse effects of labdanum. Orally, labdanum has been reported to cause nausea and stomach upset. Topically, labdanum has been reported to cause contact dermatitis.
- Kalus U, Grigorov A, Kadecki O, et al. Cistus incanus (CYSTUS052) for treating patients with infection of the upper respiratory tract. A prospective, randomised, placebo-controlled clinical study. Antiviral Res 2009;84(3):267-71.
- García-González JJ, Crespo V, Barber D, et al. Cistus ladanifer contact dermatitis. Contact Dermatitis 2001;45(4):238.
- English JSC, Cronin E. Allergic contact dermatitis from Cistus creticus. Contact Dermatitis 1988;18(2):123.
Dermatitis Dermatologic
Topically, labdanum has been reported to cause contact dermatitis. In one case report, a 32-year-old man developed dermatitis on the hand after touching a Cistus ladanifer plant during a construction project. Allergen skin tests were positive for the leaf and leaf extract. In another case report, a woman developed contact dermatitis after exposure to a Cistus creticus plant in her garden.
Nausea and vomiting Gastrointestinal
Orally, labdanum has been reported to cause nausea and stomach upset in one clinical trial.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no established or standardized medicinal dose for labdanum. It is not commonly sold as an oral supplement, and reliable human dosing information does not exist.
If you use a labdanum essential oil or skin product, follow the directions on the label and dilute essential oils as instructed. For aromatherapy, it is usually diffused or used in very small amounts for scent.
Before using labdanum for any health-related reason, check with a pharmacist or doctor, especially if you are pregnant, breastfeeding, have allergies, or take other medicines.
Labdanum & Pregnancy
Labdanum & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 3 references that drive our Labdanum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- García-González JJ, Crespo V, Barber D, et al. Cistus ladanifer contact dermatitis. Contact Dermatitis 2001;45(4):238.
- English JSC, Cronin E. Allergic contact dermatitis from Cistus creticus. Contact Dermatitis 1988;18(2):123.
- Kalus U, Grigorov A, Kadecki O, et al. Cistus incanus (CYSTUS052) for treating patients with infection of the upper respiratory tract. A prospective, randomised, placebo-controlled clinical study. Antiviral Res 2009;84(3):267-71. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Labdanum
2 brands in our database make a supplement containing Labdanum.
Supplement products with Labdanum
2 products in our database contain Labdanum. Open any to see its full ingredient list and every drug interaction we check.
Labdanum: Common Questions
What is Labdanum used for, and does it work?
Does Labdanum interact with prescription medications?
How are Labdanum interactions rated?
Is it safe to take Labdanum with my medications?
Where does this Labdanum interaction information come from?
What is Labdanum used for?
Is Labdanum safe?
Can I use Labdanum during pregnancy or breastfeeding?
Is Labdanum the same as the drug laudanum?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Labdanum
A rotating sample of real supplements in our database that list Labdanum — open any to see its full ingredients and every drug interaction we check.
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