Drug & supplement interaction

Chymotrypsin + Chlorthalidone

Chlorthalidone brand names: Hygroton, Thalitone.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Chymotrypsin and Chlorthalidone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Chlorthalidone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Chymotrypsin and Chlorthalidone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Chlorthalidone and Chymotrypsin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Chymotrypsin at all — not against Chlorthalidone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chymotrypsin safety at a glance

Chymotrypsin overall Use caution Generally tolerated for short-term use, but quality evidence is limited and some people may react to this animal-derived enzyme.
Pregnancy Avoid There is not enough safety information, so it is best to avoid use during pregnancy.
Breastfeeding Avoid Safety while breastfeeding has not been established, so avoiding it is the safer choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Chlorthalidone and Chymotrypsin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Chymotrypsin and Chlorthalidone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Hives Worth acting on Additional detail

    Chymotrypsin

    “Rarely, chymotrypsin has been reported to cause anaphylactic reactions characterized by dyspnea, urticaria, edema, shock, vascular collapse, and unconsciousness, which can lead to death (9,509).”

    Chymotrypsin · Natural Medicines adverse-effect record, reported in pregnancy-related edema.

    2 sources cited
    1. 9. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
    2. 509. Dukes, MNG. Meyler's Side Effects of Drugs. 13th ed. Elsevier: Amsterdam, 1997.

    Chlorthalidone

    Listed in the ADVERSE REACTIONS section of the FDA label for Chlorthalidone. Read the label on DailyMed ›

  • An allergic reaction Worth acting on Additional detail

    Chymotrypsin

    “There is currently a limited amount of information available about the adverse effects of chymotrypsin. Orally, hypersensitivity reactions, including anaphylaxis, have been reported (9). When injected into the eye, chymotrypsin has been reported to cause increased intraocular pressure and uveitis (9,509).”

    Chymotrypsin · Natural Medicines adverse-effect record, reported in uveitis.

    2 sources cited
    1. 9. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
    2. 509. Dukes, MNG. Meyler's Side Effects of Drugs. 13th ed. Elsevier: Amsterdam, 1997.

    Chlorthalidone

    Listed in the ADVERSE REACTIONS section of the FDA label for Chlorthalidone. Read the label on DailyMed ›

Reported for Chymotrypsin but not commonly for Chlorthalidone: a severe allergic reaction, shortness of breath and swelling.

Effects for Chlorthalidone come from the ADVERSE REACTIONS section of its FDA label; effects for Chymotrypsin come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Chlorthalidone Products Have a Food Rule — Chymotrypsin Should Not Break It

At least one FDA label for a product containing Chlorthalidone says to take it with food. If you take Chymotrypsin on an empty stomach out of habit, keep them separate — and take Chlorthalidone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Chlorthalidone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Hypertension The initial recommended dose is 15 mg once daily with food.

From the Dosage and Administration section of the FDA label we read for Chlorthalidone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Chymotrypsin or Chlorthalidone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Chymotrypsin or Chlorthalidone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Chlorthalidone

This page covers Chymotrypsin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chlorthalidone page lists 222 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Dolomite (major) and Lithium (major).

By severity: 8 major · 190 moderate · 24 minor.

From our pharmacist’s overview on the Chlorthalidone page

“Chlorthalidone (Hygroton, Thalitone) lowers blood pressure by helping the kidneys shed salt and water, and that mechanism makes its supplement interactions worth genuine care. Most of the 222 ingredients on file either add to its blood-pressure-lowering effect or act as diuretics themselves, so pressure or potassium can fall further th…”

Reviewed by 2 · Jul 18, 2026

Open the Chlorthalidone interaction page

One more smart check

Taking Chymotrypsin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 281 real supplement products containing Chymotrypsin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chymotrypsin. Even though Chymotrypsin itself has no known interaction with Chlorthalidone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chymotrypsin and Chlorthalidone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chymotrypsin
Top half

#577 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Chlorthalidone
Steady interest

#1,449 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chymotrypsin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chymotrypsin and Chlorthalidone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chymotrypsin

What is Chymotrypsin?

  • Swelling and inflammation after injury or surgery
  • Wound healing
  • Cataract surgery (intracapsular)
  • Sports injuries and sprains
  • Easing soreness and bruising

Chymotrypsin is a protein-digesting (proteolytic) enzyme, usually taken from the pancreas of cattle or pigs, that is mainly used to help reduce swelling and support healing after injury or surgery. The evidence for many of these uses is limited or low quality, so it should not replace standard care. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a bleeding or clotting condition.

Enzyme derived from animal (typically bovine or porcine) pancreas · Oral tablets (often enteric-coated), topical preparations, injectable forms (in clinical settings)

An interaction check asks whether these two react with each other — it does not ask whether Chymotrypsin is a good idea for someone in your situation. Here is what our Chymotrypsin record says about it on its own.

Chymotrypsin: dosing

There is no well-established standard dose of chymotrypsin for supplement use. Strengths vary widely between products, and it is often combined with other enzymes such as trypsin.The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Chymotrypsin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chymotrypsin monograph & all interactions
Medication

About Chlorthalidone

What Is Chlorthalidone Used For?

Brand names: Hygroton, Thalitone

Chlorthalidone is used to treat high blood pressure (hypertension) in adults. Lowering blood pressure reduces the risk of serious cardiovascular events, especially strokes and heart attacks. It can be used alone or combined with other blood pressure medicines.

Chlorthalidone is also used as an add-on treatment for edema (fluid buildup) caused by heart failure, liver cirrhosis, and kidney conditions including nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. Thalitone is additionally indicated for edema associated with heart failure, liver cirrhosis, and renal disease including nephrotic syndrome.

Most-Reported Side Effects for Chlorthalidone

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 1,258 reports
Fatigue 1,063 reports
Diarrhea 849 reports
Dizziness 758 reports
Headache 715 reports
See full Chlorthalidone drug information
Keep checking

Other Drugs & Chymotrypsin

Browse every other medication we’ve checked against Chymotrypsin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Chymotrypsin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Chymotrypsin list.

See the full Chymotrypsin interactions page
See every supplement checked against Chlorthalidone, ranked by severity
Evidence & sources

Chymotrypsin References

The 6 references that drive our Chymotrypsin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Dukes, MNG. Meyler's Side Effects of Drugs. 13th ed. Elsevier: Amsterdam, 1997.
  3. Latha B, Ramakrishnan M, Jayaraman V, Babu M. Serum enzymatic changes modulated using trypsin: chymotrypsin preparation during burn wounds in humans. Burns 1997;23:560-4. PubMed
  4. Shaw PC. The use of a trypsin-chymotrypsin formulation in fractures of the hand. Br J Clin Pract 1969;23:25-6. DOI
  5. McCue FC, Webster TM, Gieck J. Clinical effects of proteolytic enzymes after reconstructive hand surgery. Int Surg 1972;57:479-82.
  6. Sun HJ, Xiao JQ, Qiao QH, et al. Chymotrypsin with sialendoscopy-assisted surgery for the treatment of chronic obstructive parotitis. Int J Oral Maxillofac Surg 2017;46(7):877-82. doi: 10.1016/j.ijom.2017.02.1267. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chymotrypsin and Chlorthalidone Together: Common Questions

Is it safe to take Chymotrypsin with Chlorthalidone?
We do not list a known interaction between Chymotrypsin and Chlorthalidone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Chymotrypsin and Chlorthalidone have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Chymotrypsin and Chlorthalidone at the same time of day?
At least one FDA label for a product containing Chlorthalidone says to take it with food. If you take Chymotrypsin on an empty stomach out of habit, keep them separate and take Chlorthalidone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Chlorthalidone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Chlorthalidone interact with any supplements?
Yes. Chlorthalidone has documented interactions with 222 supplements in our database — Chymotrypsin is not one of them. The Chlorthalidone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chymotrypsin monograph Uses, safety profile, and every drug interaction in one place Chlorthalidone drug information The full plain-English guide to this medication Chlorthalidone supplement interactions Every supplement checked against Chlorthalidone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Chlorthalidone and Chymotrypsin?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.