Drug & supplement interaction

American Ginseng + Chlorthalidone

Chlorthalidone brand names: Hygroton, Thalitone.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between American Ginseng and Chlorthalidone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Chlorthalidone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

American Ginseng and Chlorthalidone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Chlorthalidone and American Ginseng in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

American Ginseng safety at a glance

American Ginseng overall Use caution Generally well tolerated short-term in healthy adults, but quality and dosing vary and long-term safety is not well studied.
Pregnancy Possibly Unsafe When used orally. Ginsenoside Rb1, an active constituent of American ginseng, has teratogenic effects in animal models; avoid using. Read the full pregnancy detail
Breastfeeding Avoid Too little is known about safety while breastfeeding, so avoidance is the safer choice.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Chlorthalidone and American Ginseng? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Chlorthalidone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Chlorthalidone is filed under 5 classifications — including thiazide diuretics, diuretic drugs, antihypertensive drugs. American Ginseng has documented interactions with 4 drug classes — the most serious being warfarin (coumadin) (major), antidiabetes drugs (moderate) and immunosuppressants (moderate) — and none of Chlorthalidone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

American Ginseng Does Interact With Other Medications

American Ginseng has 2 major, 215 moderate known drug interactions in our database — Chlorthalidone isn’t one of them. If you take anything else, check it against the full list below.

Major 2 Moderate 215 No known interaction 2,613 (incl. Chlorthalidone)
Taking anything else?

Check Another of Your Medications Against American Ginseng

Covers the 2,830 medications we’ve checked against American Ginseng. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests American Ginseng and Chlorthalidone May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Headache Additional detail

    American Ginseng

    “Orally, headache has been reported with American ginseng use.”

    American Ginseng · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 22369. Stavro PM, Woo M, Leiter LA, et al. Long-term intake of North American ginseng has no effect on 24-hour blood pressure and renal function. Hypertension 2006;47(4):791-6. PubMed

    Chlorthalidone

    Listed in the ADVERSE REACTIONS section of the FDA label for Chlorthalidone. Read the label on DailyMed ›

Effects for Chlorthalidone come from the ADVERSE REACTIONS section of its FDA label; effects for American Ginseng come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

American Ginseng in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. Ginsenoside Rb1, an active constituent of American ginseng, has teratogenic effects in animal models; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Chlorthalidone Products Have a Food Rule — American Ginseng Should Not Break It

At least one FDA label for a product containing Chlorthalidone says to take it with food. If you take American Ginseng on an empty stomach out of habit, keep them separate — and take Chlorthalidone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Chlorthalidone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Hypertension The initial recommended dose is 15 mg once daily with food.

From the Dosage and Administration section of the FDA label we read for Chlorthalidone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Chlorthalidone Is Prescribed For, and What American Ginseng Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Chlorthalidone is a prescription medicine with approved uses on its FDA label. American Ginseng is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Chlorthalidone is prescribed for: Chlorthalidone is used to treat high blood pressure (hypertension) in adults. Lowering blood pressure reduces the risk of serious cardiovascular events, especially strokes and heart attacks. It can be used alone or combined with other blood pressure medicines. Chlorthalidone is also used as an add-on treatment for edema (fluid buildup) caused by heart failure, liver cirrhosis, and kidney conditions including nephrotic syndrome, acute glomerulonephritis, and chronic renal failure.

Read the rest of what Chlorthalidone is prescribed for

Thalitone is additionally indicated for edema associated with heart failure, liver cirrhosis, and renal disease including nephrotic syndrome.

American Ginseng has been studied for:

  • Hypertension studied, not established American Ginseng has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    American Ginseng for hypertension

    Evidence on the use of oral American ginseng for hypertension is conflicting.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Chlorthalidone on your own; if you are taking American Ginseng for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About American Ginseng or Chlorthalidone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers American Ginseng or Chlorthalidone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Chlorthalidone

This page covers American Ginseng only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chlorthalidone page lists 222 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Dolomite (major) and Lithium (major).

By severity: 8 major · 190 moderate · 24 minor.

From our pharmacist’s overview on the Chlorthalidone page

“Chlorthalidone (Hygroton, Thalitone) lowers blood pressure by helping the kidneys shed salt and water, and that mechanism makes its supplement interactions worth genuine care. Most of the 222 ingredients on file either add to its blood-pressure-lowering effect or act as diuretics themselves, so pressure or potassium can fall further th…”

Reviewed by 2 · Jul 18, 2026

Open the Chlorthalidone interaction page

One more smart check

Taking American Ginseng as Part of a Dietary Supplement Product? Check It for Interactions

We hold 992 real supplement products containing American Ginseng, each one broken down to its full ingredient list — and combination products often carry several ingredients besides American Ginseng. Even though American Ginseng itself has no known interaction with Chlorthalidone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where American Ginseng and Chlorthalidone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement American Ginseng
Top 25%

#180 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Chlorthalidone
Top half

#804 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every American Ginseng reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The American Ginseng and Chlorthalidone records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About American Ginseng

What is American Ginseng?

American Ginseng
  • Stress and energy support
  • Immune support and colds
  • Blood sugar management
  • Mental focus and clarity
  • General wellness (adaptogen)

American ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the chance or length of colds and modestly lowering after-meal blood sugar—have early supportive evidence, but most claims are not well proven. Talk to your pharmacist or doctor before use, especially if you have a health condition or take medications.

Panax quinquefolius · Araliaceae · Root (and sometimes leaves) · Capsules, tablets, dried root, powder, tea, liquid extracts, tinctures

An interaction check asks whether these two react with each other — it does not ask whether American Ginseng is a good idea for someone in your situation. Here is what our American Ginseng record says about it on its own.

American Ginseng: dosing

There is no single official dose for American ginseng. Products differ in their root concentration and ginsenoside content, so the right amount depends on the specific product.The safest approach is to follow the directions on the product label and not exceed the recommended amount. Because it may affect sleep, many people take it earlier in the day.

From our American Ginseng monograph — the full record covers uses, side effects and every documented interaction.

Read the full American Ginseng monograph & all interactions
Medication

About Chlorthalidone

What Is Chlorthalidone Used For?

Brand names: Hygroton, Thalitone

Chlorthalidone is used to treat high blood pressure (hypertension) in adults. Lowering blood pressure reduces the risk of serious cardiovascular events, especially strokes and heart attacks. It can be used alone or combined with other blood pressure medicines.

Chlorthalidone is also used as an add-on treatment for edema (fluid buildup) caused by heart failure, liver cirrhosis, and kidney conditions including nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. Thalitone is additionally indicated for edema associated with heart failure, liver cirrhosis, and renal disease including nephrotic syndrome.

Most-Reported Side Effects for Chlorthalidone

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 1,258 reports
Fatigue 1,063 reports
Diarrhea 849 reports
Dizziness 758 reports
Headache 715 reports
See full Chlorthalidone drug information
Keep checking

Other Drugs & American Ginseng

Browse every other medication we’ve checked against American Ginseng — both the ones with a known interaction and the ones without. Select any drug for the full detail.

2Major
215Moderate
0Minor
2,612No known interaction
2 Major 215 Moderate 2,612 No interaction
Major

2 interactions

Moderate

215 interactions

Showing 60 of 215 moderate interactions — see all 215 on the American Ginseng page.

No interaction 2,612 drugs checked — show the list

We also checked American Ginseng against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,612 medications checked with no known interaction — see the full American Ginseng list.

See the full American Ginseng interactions page
See every supplement checked against Chlorthalidone, ranked by severity
Evidence & sources

American Ginseng References

The 12 references that drive our American Ginseng monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Shader RI, Greenblatt DJ. Phenelzine and the dream machine-ramblings and reflections. J Clin Psychopharmacol 1985;5:65. PubMed
  2. Jones BD, Runikis AM. Interaction of ginseng with phenelzine. J Clin Psychopharmacol 1987;7:201-2. PubMed
  3. Janetzky K, Morreale AP. Probable interaction between warfarin and ginseng. Am J Health Syst Pharm 1997;54:692-3. PubMed
  4. Vuksan V, Sievenpiper JL, Koo VY, et al. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 2000;160:1009-13. PubMed
  5. Vuksan V, Stavro MP, Sievenpiper JL, et al. Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes. Diabetes Care 2000;23:1221-6. PubMed
  6. Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
  7. McElhaney JE, Gravenstein S, Cole SK, et al. A Placebo-Controlled Trial of a Proprietary Extract of North American Ginseng (CVT-E002) to Prevent Acute Respiratory Illness in Institutionalized Older Adults. J Am Geriatr Soc 2004;52:13-9. PubMed
  8. Yuan CS, Wei G, Dey L, et al. American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled trial. Ann Intern Med 2004;141:23-7.
  9. Predy GN, Goel V, Lovlin R, et al. Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial. CMAJ 2005;173:1043-8.. PubMed
  10. McElhaney JE, Goel V, Toane B, et al. Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial. J Altern Complement Med 2006;12:153-7. PubMed
  11. Predy GN, Goel V, Lovlin RE, et al. Immune modulating effects of daily supplementation of COLD-fX (a proprietary extract of North American ginseng) in healthy adults. J Clin Biochem Nutr 2006;39:162-167. DOI
  12. Stavro PM, Woo M, Leiter LA, et al. Long-term intake of North American ginseng has no effect on 24-hour blood pressure and renal function. Hypertension 2006;47(4):791-6. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking American Ginseng and Chlorthalidone Together: Common Questions

Is it safe to take American Ginseng with Chlorthalidone?
We do not list a known interaction between American Ginseng and Chlorthalidone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do American Ginseng and Chlorthalidone have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take American Ginseng and Chlorthalidone at the same time of day?
At least one FDA label for a product containing Chlorthalidone says to take it with food. If you take American Ginseng on an empty stomach out of habit, keep them separate and take Chlorthalidone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Chlorthalidone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are American Ginseng and Chlorthalidone used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for American Ginseng in each. That is a conversation for your prescriber, especially if Chlorthalidone is being adjusted to a target.
How was the American Ginseng and Chlorthalidone combination checked?
Interactions in our licensed database are recorded against drug classes. Chlorthalidone is filed under 5 classifications, and American Ginseng has documented interactions with 4 drug classes — none of Chlorthalidone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does American Ginseng interact with any other medications?
Yes. American Ginseng has 217 documented drug interactions in our database — Chlorthalidone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Chlorthalidone interact with any supplements?
Yes. Chlorthalidone has documented interactions with 222 supplements in our database — American Ginseng is not one of them. The Chlorthalidone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

American Ginseng monograph Uses, safety profile, and every drug interaction in one place Chlorthalidone drug information The full plain-English guide to this medication Chlorthalidone supplement interactions Every supplement checked against Chlorthalidone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 12 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Chlorthalidone and American Ginseng?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.