Drug & supplement interaction

Chickweed + Chlorthalidone

Chlorthalidone brand names: Hygroton, Thalitone.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Chickweed and Chlorthalidone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Chlorthalidone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Chickweed and Chlorthalidone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Chlorthalidone and Chickweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Chickweed at all — not against Chlorthalidone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chickweed safety at a glance

Chickweed overall Use caution Generally considered low-risk for short-term use, but high-quality safety data are limited.
Pregnancy Likely Safe When used orally in the amounts commonly found in foods. There is insufficient reliable information available about the safety of chickweed when used orally in... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in the amounts commonly found in foods. There is insufficient reliable information available about the safety of chickweed when used orally in... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Chlorthalidone and Chickweed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Chickweed and Chlorthalidone May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Chickweed

    “Topically, chickweed extract has been reported to cause contact dermatitis.”

    Chickweed · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 13478. Jovanovic M, Mimica-Dukic N, Poljacki M, Boza P. Erythema multiforme due to contact with weeds: a recurrence after patch testing. Contact Dermatitis 2003;48:17-25. PubMed
    2. 41587. Jovanovic, M., Poljacki, M., Mimica-Dukic, N., Boza, P., Vujanovic, Lj, Duran, V., and Stojanovic, S. Sesquiterpene lactone mix patch testing supplemented with dandelion extract in patients with allergic contact dermatitis, atopic dermatitis and non-alle
    3. 41590. Poljacki, M., Jovanovic, M., Boza, P., Mimica-Dukic, N., Petrovic, A., and Novovic, Z. [Is Vojvodina a risk area for contact weed allergies?]. Med Pregl. 2005;58(3-4):123-126. PubMed

    Chlorthalidone

    Listed in the ADVERSE REACTIONS section of the FDA label for Chlorthalidone. Read the label on DailyMed ›

Effects for Chlorthalidone come from the ADVERSE REACTIONS section of its FDA label; effects for Chickweed come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Chickweed in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in the amounts commonly found in foods. There is insufficient reliable information available about the safety of chickweed when used orally in amounts greater than those found in food; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Chlorthalidone Products Have a Food Rule — Chickweed Should Not Break It

At least one FDA label for a product containing Chlorthalidone says to take it with food. If you take Chickweed on an empty stomach out of habit, keep them separate — and take Chlorthalidone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Chlorthalidone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Hypertension The initial recommended dose is 15 mg once daily with food.

From the Dosage and Administration section of the FDA label we read for Chlorthalidone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Chickweed or Chlorthalidone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Chickweed or Chlorthalidone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Chlorthalidone

This page covers Chickweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chlorthalidone page lists 222 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Dolomite (major) and Lithium (major).

By severity: 8 major · 190 moderate · 24 minor.

From our pharmacist’s overview on the Chlorthalidone page

“Chlorthalidone (Hygroton, Thalitone) lowers blood pressure by helping the kidneys shed salt and water, and that mechanism makes its supplement interactions worth genuine care. Most of the 222 ingredients on file either add to its blood-pressure-lowering effect or act as diuretics themselves, so pressure or potassium can fall further th…”

Reviewed by 2 · Jul 18, 2026

Open the Chlorthalidone interaction page

One more smart check

Taking Chickweed as Part of a Dietary Supplement Product? Check It for Interactions

We hold 272 real supplement products containing Chickweed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chickweed. Even though Chickweed itself has no known interaction with Chlorthalidone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chickweed and Chlorthalidone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chickweed
Top half

#414 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Chlorthalidone
Top half

#1,078 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chickweed reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chickweed and Chlorthalidone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chickweed

What is Chickweed?

Chickweed
  • Skin irritation and itching
  • Minor wounds and cuts
  • Digestive upset
  • Joint and muscle aches
  • Used historically for scurvy
  • Mild diuretic

Chickweed is a common edible wild plant traditionally used on the skin for itching and minor irritation, and taken as a tea or tincture for various complaints. Solid human studies are lacking, so its benefits are largely based on tradition rather than proof. It is generally considered low-risk when used short-term, but pregnant and breastfeeding people should avoid it due to limited safety data.

Stellaria media · Caryophyllaceae · Above-ground parts (leaves, stems, and flowers) · Tea, capsules, tincture, dried herb, creams, ointments, salves, poultices

An interaction check asks whether these two react with each other — it does not ask whether Chickweed is a good idea for someone in your situation. Here is what our Chickweed record says about it on its own.

Chickweed: dosing

There is no established, standardized dose for chickweed. It is sold in many forms, including teas, tinctures, capsules, and skin creams or ointments, and the strength varies widely between products.If you use a commercial product, follow the directions on the label.

From our Chickweed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chickweed monograph & all interactions
Medication

About Chlorthalidone

What Is Chlorthalidone Used For?

Brand names: Hygroton, Thalitone

Chlorthalidone is used to treat high blood pressure (hypertension) in adults. Lowering blood pressure reduces the risk of serious cardiovascular events, especially strokes and heart attacks. It can be used alone or combined with other blood pressure medicines.

Chlorthalidone is also used as an add-on treatment for edema (fluid buildup) caused by heart failure, liver cirrhosis, and kidney conditions including nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. Thalitone is additionally indicated for edema associated with heart failure, liver cirrhosis, and renal disease including nephrotic syndrome.

Most-Reported Side Effects for Chlorthalidone

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 1,258 reports
Fatigue 1,063 reports
Diarrhea 849 reports
Dizziness 758 reports
Headache 715 reports
See full Chlorthalidone drug information
Keep checking

Other Drugs & Chickweed

Browse every other medication we’ve checked against Chickweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Chickweed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Chickweed list.

See the full Chickweed interactions page
See every supplement checked against Chlorthalidone, ranked by severity
Evidence & sources

Chickweed References

The 4 references that drive our Chickweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Jovanovic M, Mimica-Dukic N, Poljacki M, Boza P. Erythema multiforme due to contact with weeds: a recurrence after patch testing. Contact Dermatitis 2003;48:17-25. PubMed
  3. Jovanovic, M., Poljacki, M., Mimica-Dukic, N., Boza, P., Vujanovic, Lj, Duran, V., and Stojanovic, S. Sesquiterpene lactone mix patch testing supplemented with dandelion extract in patients with allergic contact dermatitis, atopic dermatitis and non-alle
  4. Poljacki, M., Jovanovic, M., Boza, P., Mimica-Dukic, N., Petrovic, A., and Novovic, Z. [Is Vojvodina a risk area for contact weed allergies?]. Med Pregl. 2005;58(3-4):123-126. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chickweed and Chlorthalidone Together: Common Questions

Is it safe to take Chickweed with Chlorthalidone?
We do not list a known interaction between Chickweed and Chlorthalidone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Chickweed and Chlorthalidone have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Chickweed and Chlorthalidone at the same time of day?
At least one FDA label for a product containing Chlorthalidone says to take it with food. If you take Chickweed on an empty stomach out of habit, keep them separate and take Chlorthalidone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Chlorthalidone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Chlorthalidone interact with any supplements?
Yes. Chlorthalidone has documented interactions with 222 supplements in our database — Chickweed is not one of them. The Chlorthalidone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chickweed monograph Uses, safety profile, and every drug interaction in one place Chlorthalidone drug information The full plain-English guide to this medication Chlorthalidone supplement interactions Every supplement checked against Chlorthalidone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Chlorthalidone and Chickweed?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.