Drug & supplement interaction

Pata De Vaca + Chlorthalidone

Chlorthalidone brand names: Hygroton, Thalitone.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Pata De Vaca and Chlorthalidone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Chlorthalidone states a food rule worth keeping to.

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Interaction report

Pata De Vaca and Chlorthalidone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Chlorthalidone and Pata De Vaca in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Pata De Vaca safety at a glance

Pata De Vaca overall Use caution Limited human safety data, so use carefully and under professional guidance.
Pregnancy Avoid Not enough safety information; avoid during pregnancy.
Breastfeeding Avoid Not enough safety information; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Chlorthalidone and Pata De Vaca? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Chlorthalidone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Chlorthalidone is filed under 5 classifications — including thiazide diuretics, diuretic drugs, antihypertensive drugs. Pata De Vaca has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Chlorthalidone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Pata De Vaca Does Interact With Other Medications

Pata De Vaca has 86 moderate known drug interactions in our database — Chlorthalidone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Chlorthalidone)
Taking anything else?

Check Another of Your Medications Against Pata De Vaca

Covers the 2,830 medications we’ve checked against Pata De Vaca. Pick one to open its full report.

What to actually watch for

What Chlorthalidone’s Own FDA Label Lists

This is not an interaction — none of it involves Pata De Vaca. These are the most notable effects listed in the ADVERSE REACTIONS section of Chlorthalidone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 9 of them are worth acting on rather than waiting out — marked below.

  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • A severe skin reaction Worth acting on
  • A low platelet count Worth acting on
  • Anemia Worth acting on
  • Hives Worth acting on
  • A low white blood cell count Worth acting on
  • Bleeding or bruising Worth acting on
  • An allergic reaction Worth acting on
  • Erection problems

Showing the 10 most notable of 22 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Chlorthalidone. Read the label on DailyMed › Pata De Vaca’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Pata De Vaca side to compare — that is a limit of the record, not a statement that Pata De Vaca has no side effects.

How to take them

Some Chlorthalidone Products Have a Food Rule — Pata De Vaca Should Not Break It

At least one FDA label for a product containing Chlorthalidone says to take it with food. If you take Pata De Vaca on an empty stomach out of habit, keep them separate — and take Chlorthalidone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Chlorthalidone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Hypertension The initial recommended dose is 15 mg once daily with food.

From the Dosage and Administration section of the FDA label we read for Chlorthalidone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Pata De Vaca or Chlorthalidone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Pata De Vaca or Chlorthalidone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Chlorthalidone

This page covers Pata De Vaca only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chlorthalidone page lists 222 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Dolomite (major) and Lithium (major).

By severity: 8 major · 190 moderate · 24 minor.

From our pharmacist’s overview on the Chlorthalidone page

“Chlorthalidone (Hygroton, Thalitone) lowers blood pressure by helping the kidneys shed salt and water, and that mechanism makes its supplement interactions worth genuine care. Most of the 222 ingredients on file either add to its blood-pressure-lowering effect or act as diuretics themselves, so pressure or potassium can fall further th…”

Reviewed by 2 · Jul 18, 2026

Open the Chlorthalidone interaction page

One more smart check

Taking Pata De Vaca as Part of a Dietary Supplement Product? Check It for Interactions

We hold 7 real supplement products containing Pata De Vaca, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Pata De Vaca. Even though Pata De Vaca itself has no known interaction with Chlorthalidone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Pata De Vaca and Chlorthalidone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Pata De Vaca
Steady interest

#1,051 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Chlorthalidone
Steady interest

#1,449 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Pata De Vaca reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Pata De Vaca and Chlorthalidone records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Pata De Vaca

What is Pata De Vaca?

  • Blood sugar support
  • Diabetes (traditional use)
  • Diuretic
  • Kidney and urinary health
  • General tonic

Pata de Vaca is a South American plant whose leaves are traditionally brewed as a tea to help support blood sugar, earning it the nickname 'vegetable insulin.' Human evidence is very limited, so it should not replace prescribed diabetes treatment. Talk to your pharmacist or doctor before using it, especially if you take blood-sugar medications.

Bauhinia forficata · Fabaceae · Leaves · Tea (infusion), capsules, dried leaf, liquid extract

An interaction check asks whether these two react with each other — it does not ask whether Pata De Vaca is a good idea for someone in your situation. Here is what our Pata De Vaca record says about it on its own.

Pata De Vaca: dosing

There is no established standardized dose for Pata de Vaca. Traditional use is mostly as a leaf tea, but the strength of teas and supplements varies widely between products.If you choose to use it, follow the directions on the product label and start low.

From our Pata De Vaca monograph — the full record covers uses, side effects and every documented interaction.

Read the full Pata De Vaca monograph & all interactions
Medication

About Chlorthalidone

What Is Chlorthalidone Used For?

Brand names: Hygroton, Thalitone

Chlorthalidone is used to treat high blood pressure (hypertension) in adults. Lowering blood pressure reduces the risk of serious cardiovascular events, especially strokes and heart attacks. It can be used alone or combined with other blood pressure medicines.

Chlorthalidone is also used as an add-on treatment for edema (fluid buildup) caused by heart failure, liver cirrhosis, and kidney conditions including nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. Thalitone is additionally indicated for edema associated with heart failure, liver cirrhosis, and renal disease including nephrotic syndrome.

Most-Reported Side Effects for Chlorthalidone

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 1,258 reports
Fatigue 1,063 reports
Diarrhea 849 reports
Dizziness 758 reports
Headache 715 reports
See full Chlorthalidone drug information
Keep checking

Other Drugs & Pata De Vaca

Browse every other medication we’ve checked against Pata De Vaca — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Pata De Vaca page.

No interaction 2,743 drugs checked — show the list

We also checked Pata De Vaca against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Pata De Vaca list.

See the full Pata De Vaca interactions page
See every supplement checked against Chlorthalidone, ranked by severity
Evidence & sources

Pata De Vaca References

The 10 references that drive our Pata De Vaca monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Russo EM, Reichelt AA, De Sa JR, et al. Clinical trial of Myrcia uniflora and Bauhinia forficata leaf extracts in normal and diabetic patients. Braz J Med Biol Res 1990;23(1):11-20.
  2. da Cunha AM, Menon S, Menon R, et al. Hypoglycemic activity of dried extracts of Bauhinia forficata Link. Phytomedicine 2010;17(1):37-41. PubMed
  3. Lino Cde S, Diogenes JP, Pereira BA, et al. Antidiabetic activity of Bauhinia forficata extracts in alloxan-diabetic rats. Biol Pharm Bull 2004;27(1):125-7. PubMed
  4. Silva FR, Szpoganicz B, Pizzolatti MG, et al. Acute effect of Bauhinia forficata on serum glucose levels in normal and alloxan-induced diabetic rats. J Ethnopharmacol 2002;83(1-2):33-7. PubMed
  5. Pepato MT, Keller EH, Baviera AM, et al. Anti-diabetic activity of Bauhinia forficata decoction in streptozotocin-diabetic rats. J Ethnopharmacol 2002;81(2):191-7. PubMed
  6. Jorge AP, Horst H, de Sousa E, et al. Insulinomimetic effects of kaempferitrin on glycaemia and on 14C-glucose uptake in rat soleus muscle. Chem Biol Interact 2004;149(2-3):89-96. PubMed
  7. de Sousa E, Zanatta L, Seifriz I, et al. Hypoglycemic effect and antioxidant potential of kaempferol-3,7-O-(alpha)-dirhamnoside from Bauhinia forficata leaves. J Nat Prod 2004;67(5):829-32.
  8. Vasconcelos F, Sampaio SV, Garofalo MA, et al. Insulin-like effects of Bauhinia forficata aqueous extract upon Tityus serrulatus scorpion envenoming. J Ethnopharmacol 2004;95(2-3):385-92. PubMed
  9. Córdova Mariángel P, Avello Lorca M, Morales Leon F, et al. Effects of Bauhinia forficata link tea on lipid profile in diabetic patients. J Med Food. 2019;22(3):321-323.
  10. Tonelli CA, de Oliveira SQ, Silva Vieira AAD, et al. Clinical efficacy of capsules containing standardized extract of Bauhinia forficata Link (pata-de-vaca) as adjuvant treatment in type 2 diabetes patients: A randomized, double blind clinical trial. J Et PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Pata De Vaca and Chlorthalidone Together: Common Questions

Is it safe to take Pata De Vaca with Chlorthalidone?
We do not list a known interaction between Pata De Vaca and Chlorthalidone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Pata De Vaca and Chlorthalidone at the same time of day?
At least one FDA label for a product containing Chlorthalidone says to take it with food. If you take Pata De Vaca on an empty stomach out of habit, keep them separate and take Chlorthalidone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Chlorthalidone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Pata De Vaca and Chlorthalidone combination checked?
Interactions in our licensed database are recorded against drug classes. Chlorthalidone is filed under 5 classifications, and Pata De Vaca has documented interactions with 1 drug class — none of Chlorthalidone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Pata De Vaca interact with any other medications?
Yes. Pata De Vaca has 86 documented drug interactions in our database — Chlorthalidone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Chlorthalidone interact with any supplements?
Yes. Chlorthalidone has documented interactions with 222 supplements in our database — Pata De Vaca is not one of them. The Chlorthalidone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Pata De Vaca monograph Uses, safety profile, and every drug interaction in one place Chlorthalidone drug information The full plain-English guide to this medication Chlorthalidone supplement interactions Every supplement checked against Chlorthalidone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Chlorthalidone and Pata De Vaca?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.