Drug & supplement interaction

Docosahexaenoic Acid (dha) + Indapamide

Indapamide brand names: Lozol, Lozide.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Docosahexaenoic Acid (dha) has a moderate interaction with Indapamide. Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Docosahexaenoic Acid (dha) and Indapamide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIHYPERTENSIVE DRUGS

Why this applies to Indapamide

Indapamide falls under ANTIHYPERTENSIVE DRUGS — the group Docosahexaenoic Acid (dha) interacts with.

Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.
Fish oils containing DHA can lower blood pressure and might have additive effects in patients treated with antihypertensives; use with caution.
Severity Moderate Likelihood Probable Evidence B

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: indapamide is a water pill that lowers your blood pressure, and DHA (the omega-3 from fish oil) can nudge blood pressure down a little too. Put them together and those two effects can stack, so your pressure might dip a bit more than expected.

What that can feel like with indapamide is dizziness, lightheadedness (especially when you stand up quickly), tiredness, or feeling faint. This is rated a moderate, likely interaction, but the evidence behind it is fairly modest. Many people take fish oil and a blood pressure pill together without trouble. I wouldn't stop either one on your own. Just give your pharmacist or doctor a heads-up, keep an eye on your home readings, and tell them if you feel woozy.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Prisco D, Paniccia R, Bandinelli B, et al. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. Thromb Res 1998;1:105-12.
  2. Toft I, Bonaa KH, Ingebretsen OC, et al. Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. Ann Intern Med 1995;123:911-8.
  3. Sacks FM, Hebert P, Appel LJ, et al. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the trials of hypertension prevention. J Hypertens 1994;12:209-13.
  4. Vandongen R, Mori TA, Burke V, et al. Effects on blood pressure of omega 3 fats in subjects at increased risk of cardiovascular disease. Hypertension 1993;22:371-9. PubMed
  5. Mori, T. A., Bao, D. Q., Burke, V., Puddey, I. B., and Beilin, L. J. Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension 1999;34(2):253-260. PubMed
  6. Nestel, P., Shige, H., Pomeroy, S., Cehun, M., Abbey, M., and Raederstorff, D. The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am.J.Clin.Nutr. 2002;76(2):326-330. PubMed
  7. Woodman, R. J., Mori, T. A., Burke, V., Puddey, I. B., Barden, A., Watts, G. F., and Beilin, L. J. Effects of purified eicosapentaenoic acid and docosahexaenoic acid on platelet, fibrinolytic and vascular function in hypertensive type 2 diabetic patients PubMed
  8. Theobald, H. E., Goodall, A. H., Sattar, N., Talbot, D. C., Chowienczyk, P. J., and Sanders, T. A. Low-dose docosahexaenoic acid lowers diastolic blood pressure in middle-aged men and women. J Nutr 2007;137(4):973-978.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Docosahexaenoic Acid (dha) Also Interacts With Other Medications

Docosahexaenoic Acid (dha) has 374 moderate known drug interactions in our database — the Indapamide one above is one of them. If you take anything else, check it against the full list below.

Moderate 374 No known interaction 2,456 (incl. Indapamide)
Taking anything else?

Check Another of Your Medications Against Docosahexaenoic Acid (dha)

Covers the 2,830 medications we’ve checked against Docosahexaenoic Acid (dha). Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Indapamide

This page covers Docosahexaenoic Acid (dha) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Indapamide page lists 215 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Arsenic (major) and Cesium (major).

By severity: 13 major · 179 moderate · 23 minor.

From our pharmacist’s overview on the Indapamide page

“A water pill like indapamide (Lozol) lowers blood pressure and pulls potassium down, and most of the 215 supplements and herbs on file press on those same levers. Thirteen entries rate major, so this is a list to read with real care rather than skim.”

Reviewed by 2 · Jul 18, 2026

Open the Indapamide interaction page

How much people look this up

Where Docosahexaenoic Acid (dha) and Indapamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Docosahexaenoic Acid (dha)
Steady interest

#1,209 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Indapamide
Steady interest

#1,758 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Docosahexaenoic Acid (dha)

What is Docosahexaenoic Acid (dha)?

Docosahexaenoic Acid (dha)
  • Brain and cognitive health
  • Eye and vision health
  • Fetal and infant development
  • Heart and triglyceride support
  • General omega-3 supplementation

DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes. It is widely used and generally well tolerated, with the strongest support for fetal/infant development and lowering triglycerides; evidence for many other uses is mixed. Talk with your pharmacist or doctor before starting, especially if you are pregnant, have a bleeding risk, or take blood thinners.

Read the full Docosahexaenoic Acid (dha) monograph & all interactions
Medication

About Indapamide

What Is Indapamide Used For?

Brand names: Lozol, Lozide

Indapamide tablets are used to treat high blood pressure (hypertension), either on their own or together with other blood pressure medications. Lowering blood pressure helps reduce the risk of related complications.

Indapamide tablets are also used to treat salt and fluid retention (edema) associated with congestive heart failure. In certain cases, indapamide may also be appropriate during pregnancy when swelling is caused by a medical condition rather than normal pregnancy changes — but routine use in otherwise healthy pregnant women is not recommended.

See full Indapamide drug information
Keep checking

Other Drugs & Docosahexaenoic Acid (dha)

Browse every other medication we’ve checked against Docosahexaenoic Acid (dha) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
374Moderate
0Minor
2,455No known interaction
374 Moderate 2,455 No interaction
Moderate

374 interactions

Showing 60 of 374 moderate interactions — see all 374 on the Docosahexaenoic Acid (dha) page.

No interaction 2,455 drugs checked — show the list

We also checked Docosahexaenoic Acid (dha) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,455 medications checked with no known interaction — see the full Docosahexaenoic Acid (dha) list.

See the full Docosahexaenoic Acid (dha) interactions page
See every supplement checked against Indapamide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Docosahexaenoic Acid (dha) monograph › Uses, safety, and every drug interaction in one place Indapamide supplement interactions › Every supplement checked against Indapamide, ranked by severity Indapamide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Docosahexaenoic Acid (dha) and Indapamide Together: Common Questions

Can you take Docosahexaenoic Acid (dha) with Indapamide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Docosahexaenoic Acid (dha) and Indapamide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Indapamide and Docosahexaenoic Acid (dha)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.