Oriental Arborvitae Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Oriental Arborvitae interacts with medications. The heart of this page is the interaction list — every drug Oriental Arborvitae is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Oriental Arborvitae is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Oriental Arborvitae against your medication
Add one medicationDrugs that interact with Oriental Arborvitae
0 medications have a known interaction with Oriental Arborvitae, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Oriental Arborvitae. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Oriental Arborvitae combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Oriental Arborvitae: Uses, Safety & Side Effects
Oriental Arborvitae is an evergreen conifer used in Traditional Chinese Medicine, where the seeds (Bai Zi Ren) are taken to calm the mind and ease constipation, and the leaves (Ce Bai Ye) are used for bleeding and hair loss. Solid human evidence for these uses is limited, and parts of the plant can be toxic if misused. Talk with a pharmacist or doctor before trying it, and avoid it in pregnancy.

- Scientific name
- Platycladus orientalis
- Family
- Cupressaceae
- Part used
- Seeds (Bai Zi Ren) and leaves/twigs (Ce Bai Ye)
- Common forms
- Dried seeds, dried leaf, decoctions (teas), powders, capsules, and topical preparations
- Insomnia and restlessness
- Constipation (seeds)
- Hair loss and scalp health (topical)
- Bleeding and heavy menstruation (traditional)
- Cough and respiratory complaints
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Some plant parts and oils can be toxic, and human safety data are limited.
When the leafy twig is used orally during pregnancy. Oriental arborvitae contains thujone. Thujone might stimulate uterine activity; avoid using. Ther...
Read the full pregnancy detailThere is insufficient reliable information available about the safety of oriental arborvitae when used orally or topically during lactation; avoid usi...
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Oriental Arborvitae (Platycladus orientalis) is an evergreen conifer tree native to East Asia. It is widely planted in gardens and landscapes for its dense, scale-like foliage, but it also has a long history in Traditional Chinese Medicine (TCM).
In TCM, two different parts are used and have different names. The seeds are called Bai Zi Ren and are used mainly to calm the mind and to soften the stool. The leaves and young twigs are called Ce Bai Ye and are used traditionally for bleeding problems and for the scalp and hair.
Today you may find it as dried herb for teas (decoctions), powders, capsules, or in topical products such as hair tonics. It is far more common in TCM practice than as a standalone Western supplement.
How it works
The plant contains a mix of natural compounds, including flavonoids, essential oils (with substances such as thujone and other terpenes), tannins, and fatty oils in the seeds.
The fatty oil in the seeds is thought to explain the gentle stool-softening, laxative effect. Flavonoids and other antioxidants found in the leaves may have antioxidant, anti-inflammatory, and antimicrobial actions in laboratory tests, and some lab studies suggest effects on hair-related cell pathways.
Most of these mechanisms come from test-tube and animal research. It is not clear how well they translate to real benefits in people at safe doses.
Does Oriental Arborvitae work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Oriental Arborvitae, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Osteoarthritis
It is unclear if oral oriental arborvitae is beneficial in patients with osteoarthritis.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
Safety information for humans is limited, so a cautious approach is wise. The essential oil contains thujone, a compound that can be toxic to the nervous system in larger amounts and may trigger seizures. Concentrated oils and large doses are the main concern.
People with a history of seizures, kidney or liver problems, or those who are frail or elderly should be especially careful. Children should not use it without medical supervision.
Pregnancy: Avoid. It is traditionally avoided in pregnancy, and there is not enough safety data to consider it safe. Breastfeeding: Avoid, because no reliable safety information is available.
Because product quality and the part of the plant used can vary, talk to a pharmacist, doctor, or qualified TCM practitioner before using it.
Side effects
When the seeds are used in usual food-like amounts, the most common side effects are digestive, such as loose stools, diarrhea, or stomach upset.
More serious problems are linked to the concentrated essential oil or to high doses, and may include nausea, vomiting, dizziness, and—because of the thujone content—nervous system effects such as agitation or, rarely, seizures. Allergic reactions are possible, especially with topical use.
Stop using it and seek medical care if you have a severe reaction, trouble breathing, or any unusual neurological symptoms.
Oriental Arborvitae: Reported Adverse Effects
Documented safety reports on Oriental Arborvitae from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Orally, taking oriental arborvitae long-term or at high doses might cause adverse effects due to the thujone constituent. Thujone-containing herbs can cause restlessness, vomiting, dizziness, tremors, kidney damage, hallucinations, and convulsions when used long-term or at high doses. Thujone intoxication can cause psychoactivity similar to tetrahydrocannibinol, the active constituent in marijuana..
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Nausea and vomiting Gastrointestinal
Orally, thujone-containing herbs such as oriental arborvitae may cause vomiting when used long-term or at high doses.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Vertigo Neurologic/CNS
Orally, thujone-containing herbs such as oriental arborvitae may cause dizziness and convulsions when used long-term or at high doses.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no well-established standardized dose for Oriental Arborvitae as a supplement. In Traditional Chinese Medicine, the seeds and leaves are used in specific amounts within formulas prepared by a trained practitioner, and the right amount depends on the part used and the preparation.
If you choose to use a commercial product, follow the directions on the label and do not exceed them. Never ingest the concentrated essential oil unless directed by a qualified professional. When in doubt, check with a pharmacist, doctor, or licensed TCM practitioner first.
Oriental Arborvitae & Pregnancy
Oriental Arborvitae & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 2 references that drive our Oriental Arborvitae monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Oriental Arborvitae
23 brands in our database make a supplement containing Oriental Arborvitae.
Supplement products with Oriental Arborvitae
76 products in our database contain Oriental Arborvitae. Open any to see its full ingredient list and every drug interaction we check.
Oriental Arborvitae: Common Questions
What is Oriental Arborvitae used for, and does it work?
Does Oriental Arborvitae interact with prescription medications?
How are Oriental Arborvitae interactions rated?
Is it safe to take Oriental Arborvitae with my medications?
Where does this Oriental Arborvitae interaction information come from?
What is Oriental Arborvitae used for?
Is Oriental Arborvitae safe to take?
Can I use it during pregnancy or while breastfeeding?
Are the seeds and the leaves the same thing?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Oriental Arborvitae
A rotating sample of real supplements in our database that list Oriental Arborvitae — open any to see its full ingredients and every drug interaction we check.
- Calm Nature by HoltraCeuticals
- Peaceful Rest by New Sun
- Bai Zi Ren Non-Alcohol by Hawaii Pharm
- Hemrolyn by Princess Lifestyle
- Lights Out by Ron Teeguarden's Dragon Herbs
- Emperor's Teapills by Plum Flower
- Emperor's Ginseng Zizyphus by Health Concerns
- Bai Zi Yang Xin Wan by Min Shan
- Bai Zi Ren Non-Alcohol by Hawaii Pharm
- Bai Zi Ren Alcohol Free by Herbal Terra
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