Drug & supplement interaction

Bifidobacterium Breve + Dirithromycin

Dirithromycin brand name: Dynabac.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Bifidobacterium Breve has a moderate interaction with Dirithromycin. Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Bifidobacterium Breve and Dirithromycin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIBIOTIC DRUGS

Why this applies to Dirithromycin

Dirithromycin falls under ANTIBIOTIC DRUGS — the group Bifidobacterium Breve interacts with.

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: Dirithromycin is an antibiotic, and it doesn't tell the difference between bad bacteria and the good ones in your probiotic. Bifidobacterium breve is a live, friendly gut bacterium. If you swallow it at the same time as this antibiotic, the dirithromycin may kill off a good chunk of those probiotic organisms before they can do their job, so you'd get less benefit from the supplement.

The good news is this works the other way around too: it doesn't make the antibiotic dangerous or weaker, it just wastes the probiotic. This is a theory based on how the drug works, not hard proof. To play it safe, simply space them out by at least 2 hours. When in doubt, your pharmacist can help you set up the timing.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Bifidobacterium Breve Also Interacts With Other Medications

Bifidobacterium Breve has 181 moderate known drug interactions in our database — the Dirithromycin one above is one of them. If you take anything else, check it against the full list below.

Moderate 181 No known interaction 2,649 (incl. Dirithromycin)
Taking anything else?

Check Another of Your Medications Against Bifidobacterium Breve

Covers the 2,830 medications we’ve checked against Bifidobacterium Breve. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Dirithromycin

This page covers Bifidobacterium Breve only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dirithromycin page lists 55 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Oleander (major), Bacillus Coagulans (moderate), Bacillus Subtilis (moderate) and Bifidobacterium Animalis Subsp. Lactis (moderate).

By severity: 2 major · 43 moderate · 10 minor.

From our pharmacist’s overview on the Dirithromycin page

“Activated charcoal is the pairing I would stop first with dirithromycin (Dynabac). It can soak up the antibiotic in the gut and cut how much reaches the bloodstream, and it is one of only two major-rated entries among the 55 supplements on this page.”

Reviewed by 2 · Jul 18, 2026

Open the Dirithromycin interaction page

One more smart check

Taking Bifidobacterium Breve as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,771 real supplement products containing Bifidobacterium Breve, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bifidobacterium Breve. Your product may carry other ingredients that interact with Dirithromycin too, on top of Bifidobacterium Breve — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bifidobacterium Breve and Dirithromycin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bifidobacterium Breve
Top 25%

#173 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dirithromycin
Top 5%

#81 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Bifidobacterium Breve

What is Bifidobacterium Breve?

  • Digestive health and regularity
  • Infant colic and gut support
  • Diarrhea (including antibiotic-related)
  • Constipation
  • General immune and gut microbiome support

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain digestive and infant conditions, but evidence is still limited and varies by strain. It is generally well tolerated in healthy people, but anyone with a weak immune system or serious illness should check with a doctor or pharmacist first.

Read the full Bifidobacterium Breve monograph & all interactions
Keep checking

Other Drugs & Bifidobacterium Breve

Browse every other medication we’ve checked against Bifidobacterium Breve — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
181Moderate
0Minor
2,648No known interaction
181 Moderate 2,648 No interaction
Moderate

181 interactions

Showing 60 of 181 moderate interactions — see all 181 on the Bifidobacterium Breve page.

No interaction 2,648 drugs checked — show the list

We also checked Bifidobacterium Breve against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,648 medications checked with no known interaction — see the full Bifidobacterium Breve list.

See the full Bifidobacterium Breve interactions page
See every supplement checked against Dirithromycin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Bifidobacterium Breve monograph › Uses, safety, and every drug interaction in one place Dirithromycin supplement interactions › Every supplement checked against Dirithromycin, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Bifidobacterium Breve and Dirithromycin Together: Common Questions

Can you take Bifidobacterium Breve with Dirithromycin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Bifidobacterium Breve and Dirithromycin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Dirithromycin and Bifidobacterium Breve?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.