Medication interaction hub

What Supplements Interact with Amoxicillin?

Amoxicillin brand names: Amoxil Capsules, Trimox, Wymox, Amix, Amoram, and others. Every interaction below applies to the brands too.

96 Interactions 6 Major 76 Moderate 14 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Amoxicillin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Amoxicillin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Amoxicillin, one of the most commonly prescribed antibiotics, has 96 supplement and herbal ingredients flagged against it, and six carry a major rating, which puts this list in the read-carefully category. The serious entries mostly add strain to organs the drug already touches. Ordinary beer and wine raise the odds of liver injury alongside it, and a few botanicals can compound kidney harm. Khat stands out too, since chewing it within two hours of a dose cuts how much amoxicillin reaches your bloodstream.

The 76 moderate and 14 minor entries work in quieter ways. Antibiotics kill the live organisms in probiotic products, so those lose their benefit if swallowed together, and several gums and fibers can trap the drug in the gut and lower its levels. Space anything oral well apart from each dose, and if the infection seems slow to clear, tell your prescriber what else you were taking.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 76 Minor 14 No known interaction 1,356

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Amoxicillin: Top Interactions at a Glance

The Amoxicillin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 96 interacting ingredients — plus 1,356 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Amoxicillin Combinations Today

The Amoxicillin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Bifidobacterium Bifidum + Amoxicillini

Theoretically, taking Bifidobacterium.

Read the full interaction Moderate Likelihood Probable Lactobacillus Acidophilus + Amoxicillini

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Longum + Amoxicillini

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Possible Melatonin + Amoxicillini

Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Read the full interaction Moderate Likelihood Probable Bacillus Coagulans + Amoxicillini

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Lactobacillus Delbrueckii + Amoxicillini

Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction
The complete list

Every Supplement Checked Against Amoxicillin

All 1,452 ingredients in our database, ranked by severity — 96 with a Amoxicillin interaction on file and 1,356 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Amoxicillin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bifidobacterium Bifidum with Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium.

Full Bifidobacterium Bifidum + Amoxicillin answer

Can you take Lactobacillus Acidophilus with Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Acidophilus + Amoxicillin answer

Can you take Bifidobacterium Longum with Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Longum + Amoxicillin answer

Can you take Melatonin with Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Amoxicillin answer

Can you take Bacillus Coagulans with Amoxicillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Full Bacillus Coagulans + Amoxicillin answer

Can you take Thyroid Extract with Amoxicillin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Amoxicillin answer

Can you take Agar with Amoxicillin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Amoxicillin answer

Can you take Algin with Amoxicillin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Amoxicillin answer

Can you take Black Pepper with Amoxicillin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, black pepper might increase the effects and side effects of amoxicillin.

Full Black Pepper + Amoxicillin answer

Can you take Black Psyllium with Amoxicillin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Amoxicillin answer

Can you take Blond Psyllium with Amoxicillin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Amoxicillin answer

Can you take Carob with Amoxicillin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Amoxicillin answer

Can you take Indian Long Pepper with Amoxicillin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Indian long pepper might increase the effects and adverse effects of amoxicillin.

Full Indian Long Pepper + Amoxicillin answer

Can you take Karaya Gum with Amoxicillin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Amoxicillin answer

Can you take Marshmallow with Amoxicillin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Amoxicillin answer

Can you take Soy with Amoxicillin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, antibiotics may decrease the activity of soy isoflavones.

Full Soy + Amoxicillin answer

Can you take White Pepper with Amoxicillin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Evidence from animal research shows that piperine, a constituent of white pepper, increases the plasma levels of amoxicillin when taken conc...

Full White Pepper + Amoxicillin answer

Can you take Xanthan Gum with Amoxicillin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Amoxicillin answer

Can you take Asian Water Plantain with Amoxicillin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg o...

Full Asian Water Plantain + Amoxicillin answer

Can you take Khat with Amoxicillin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Clinical research shows that chewing khat reduces the bioavailability of amoxicillin when taken within 2 hours.

Full Khat + Amoxicillin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Amoxicillin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Amoxicillin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Amoxicillin sits in 7 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Amoxicillin through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Amoxicillin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Amoxicillin through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Amoxicillin through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Amoxicillin through this category.

Amoxicillin (Amoxil, Trimox) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Amoxicillin through this category.

Penicillin 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Amoxicillin through this category.

About Amoxicillin

Amoxicillin is a penicillin-like antibiotic used to treat bacterial infections like pneumonia, bronchitis, and ear, nose, throat, urinary tract, and skin infections.

Generic name: Amoxicillin  ·  Brand names: Amoxil Capsules, Trimox, Wymox, Amix, Amoram, Amoxident, Galenamox, Rimoxallin, Amoxil Injection.

See the full Amoxicillin drug information

Related: does Amoxicillin deplete any nutrients?

Amoxicillin has 72 reported nutrient associations in the research literature — see the Amoxicillin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Amoxicillin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Amoxicillin.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Prefer typing? The interaction checker looks up products by name too.

Products that contain Amoxicillin-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Amoxicillin.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Amoxicillin & Supplements: Common Questions

What supplements interact with Amoxicillin?
More than you might expect — 96 in total, though they are far from equal: 6 are rated major, 76 moderate, and 14 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Khat, Siberian Cocklebur, Activated Charcoal.
Which Amoxicillin supplement interactions are the most serious?
The 6 major-rated combinations — led by Khat, Siberian Cocklebur, Activated Charcoal, Beer and Wine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Amoxicillin?
Usually yes — most people on Amoxicillin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Amoxil Capsules have the same supplement interactions as Amoxicillin?
Yes — Amoxil Capsules, Trimox, Wymox, Amix, Amoram and other brands all contain Amoxicillin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Amoxicillin deplete any vitamins or nutrients?
It might — Amoxicillin has 72 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Amoxicillin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Amoxicillin and my other medications?
This page covers Amoxicillin against supplements and herbal ingredients. Checking Amoxicillin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Amoxicillin drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.