Medication interaction hub

What Supplements Interact with Nalidixic Acid?

Nalidixic Acid brand name: NegGram. Every interaction below applies to the brands too.

146 Interactions 8 Major 118 Moderate 20 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Nalidixic Acid? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Nalidixic Acid against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

146 supplements and herbal ingredients have interactions with Nalidixic Acid on file in the HelloPharmacist interaction database — 8 rated major, 118 moderate, and 20 minor. The most serious involve Apple, Grapefruit, Siberian Cocklebur, Sweet Orange and Activated Charcoal.

Our assessment: with 8 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Nalidixic Acid.

Major 8 Moderate 118 Minor 20 No known interaction 1,306

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Nalidixic Acid: Top Interactions at a Glance

The Nalidixic Acid supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 146 interacting ingredients — plus 1,306 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Nalidixic Acid Combinations Today

The Nalidixic Acid + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Zinc + Nalidixic Acidi

Zinc can decrease the levels and clinical effects of quinolones antibiotics.

Read the full interaction Moderate Likelihood Possible Niacin + Nalidixic Acidi

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full interaction Moderate Likelihood Possible Rue + Nalidixic Acidi

Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.

Read the full interaction Moderate Likelihood Probable Whey Protein + Nalidixic Acidi

Theoretically, whey protein might decrease quinolone absorption.

Read the full interaction Moderate Likelihood Possible Kudzu + Nalidixic Acidi

Theoretically, concomitant use might have additive hepatotoxic effects.

Read the full interaction Moderate Likelihood Possible Boldo + Nalidixic Acidi

Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.

Read the full interaction
The complete list

Every Supplement Checked Against Nalidixic Acid

All 1,452 ingredients in our database, ranked by severity — 146 with a Nalidixic Acid interaction on file and 1,306 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Nalidixic Acid?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Zinc with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Zinc can decrease the levels and clinical effects of quinolones antibiotics.

Full Zinc + Nalidixic Acid answer

Can you take Niacin with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Full Niacin + Nalidixic Acid answer

Can you take Rue with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.

Full Rue + Nalidixic Acid answer

Can you take Whey Protein with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, whey protein might decrease quinolone absorption.

Full Whey Protein + Nalidixic Acid answer

Can you take Kudzu with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Kudzu + Nalidixic Acid answer

Can you take Bifidobacterium Bifidum with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium.

Full Bifidobacterium Bifidum + Nalidixic Acid answer

Can you take Bifidobacterium Breve with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Breve + Nalidixic Acid answer

Can you take Bifidobacterium Longum with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Longum + Nalidixic Acid answer

Can you take Black Tea with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.

Full Black Tea + Nalidixic Acid answer

Can you take Caffeine with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.

Full Caffeine + Nalidixic Acid answer

Can you take Calcium with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Calcium seems to reduce the absorption of quinolone antibiotics.

Full Calcium + Nalidixic Acid answer

Can you take Chenopodium Oil with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of chenopodium oil with other photosensitizing drugs can increase the risk of adverse effects.

Full Chenopodium Oil + Nalidixic Acid answer

Can you take Chlorophyll with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.

Full Chlorophyll + Nalidixic Acid answer

Can you take Chlorophyllin with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.

Full Chlorophyllin + Nalidixic Acid answer

Can you take Cocoa with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.

Full Cocoa + Nalidixic Acid answer

Can you take Coconut Water with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Many quinolone antibiotics, such as ciprofloxacin and levofloxacin, may have reduced absorption when taken with calcium-containing products...

Full Coconut Water + Nalidixic Acid answer

Can you take Coffee with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.

Full Coffee + Nalidixic Acid answer

Can you take Coffee Charcoal with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Nalidixic Acid answer

Can you take Cola Nut with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, quinolone antibiotics might increase the levels and adverse effects of the caffeine in cola nut.

Full Cola Nut + Nalidixic Acid answer

Can you take Dolomite with Nalidixic Acid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the magnesium in dolomite might decrease the absorption of quinolone antibiotics.

Full Dolomite + Nalidixic Acid answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Nalidixic Acid is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Nalidixic Acid, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Nalidixic Acid sits in 9 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Nalidixic Acid through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Nalidixic Acid through this category.

Quinolone Antibiotics 24 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

24 of the supplement ingredients on this page reach Nalidixic Acid through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Nalidixic Acid through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Nalidixic Acid through this category.

Organic Anion-Transporting Polypeptide Substrates (Oatp) 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Nalidixic Acid through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Nalidixic Acid through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Nalidixic Acid through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Nalidixic Acid through this category.

Related: does Nalidixic Acid deplete any nutrients?

Nalidixic Acid has 11 reported nutrient associations in the research literature — see the Nalidixic Acid nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Nalidixic Acid

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Nalidixic Acid.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Nalidixic Acid & Supplements: Common Questions

What supplements interact with Nalidixic Acid?
More than you might expect — 146 in total, though they are far from equal: 8 are rated major, 118 moderate, and 20 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Apple, Grapefruit, Siberian Cocklebur.
Which Nalidixic Acid supplement interactions are the most serious?
Focus on the major group: Apple, Grapefruit, Siberian Cocklebur, Sweet Orange and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Nalidixic Acid?
Usually yes — most people on Nalidixic Acid can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like NegGram have the same supplement interactions as Nalidixic Acid?
Yes — NegGram all contain Nalidixic Acid, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Nalidixic Acid deplete any vitamins or nutrients?
It might — Nalidixic Acid has 11 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Nalidixic Acid nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Nalidixic Acid and my other medications?
This page covers Nalidixic Acid against supplements and herbal ingredients. Checking Nalidixic Acid against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.