Medication interaction hub

What Supplements Interact with Moxifloxacin?

Moxifloxacin brand name: Avelox. Every interaction below applies to the brands too.

155 Interactions 13 Major 121 Moderate 21 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Moxifloxacin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Moxifloxacin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

The supplement list for moxifloxacin (Avelox), a fluoroquinolone antibiotic, deserves genuine care, and the everyday items are the surprising part. Ordinary juices, apple, grapefruit, and sweet orange among them, block a transporter the drug needs for absorption and can cut how much reaches your blood, which for an antibiotic means the infection may go undertreated. Alcohol raises the stakes alongside a large group of liver-stressing ingredients, and thirteen entries can add to moxifloxacin's own known tendency to disturb heart rhythm.

Moxifloxacin already makes skin more sensitive to sun, and twenty of these ingredients pile onto that. Probiotics are a gentler problem; the antibiotic simply kills them, so they need separate timing to survive. Of the 155 ingredients on file, most sit in the moderate range, with 13 rated major and 21 minor. Read those 13 first, the juices included, since they can quietly undercut the entire course.

— , Clinical Pharmacist · July 18, 2026

Major 13 Moderate 121 Minor 21 No known interaction 1,297

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Moxifloxacin: Top Interactions at a Glance

The Moxifloxacin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 155 interacting ingredients — plus 1,297 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Moxifloxacin Combinations Today

The Moxifloxacin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Red Yeast Rice + Moxifloxacini

Theoretically, concomitant use might increase the risk of liver damage.

Read the full interaction Moderate Likelihood Probable Iron + Moxifloxacini

Iron might decrease levels of quinolone antibiotics by reducing their absorption.

Read the full interaction Major Likelihood Possible Asarabacca + Moxifloxacini

Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Read the full interaction Moderate Likelihood Probable Whey Protein + Moxifloxacini

Theoretically, whey protein might decrease quinolone absorption.

Read the full interaction Major Likelihood Possible American Hellebore + Moxifloxacini

American hellebore, also known as Veratrum viride, contains alkaloids that can potentially prolong the QT interval on an electrocardiogram (ECG).

Read the full interaction Moderate Likelihood Possible Gotu Kola + Moxifloxacini

Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Moxifloxacin

All 1,452 ingredients in our database, ranked by severity — 155 with a Moxifloxacin interaction on file and 1,297 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Moxifloxacin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Red Yeast Rice with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of liver damage.

Full Red Yeast Rice + Moxifloxacin answer

Can you take Iron with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Iron might decrease levels of quinolone antibiotics by reducing their absorption.

Full Iron + Moxifloxacin answer

Can you take Asarabacca with Moxifloxacin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Full Asarabacca + Moxifloxacin answer

Can you take Whey Protein with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, whey protein might decrease quinolone absorption.

Full Whey Protein + Moxifloxacin answer

Can you take American Hellebore with Moxifloxacin?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. American hellebore, also known as Veratrum viride, contains alkaloids that can potentially prolong the QT interval on an electrocardiogram (...

Full American Hellebore + Moxifloxacin answer

Can you take Guar Gum with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Moxifloxacin answer

Can you take Gum Arabic with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Moxifloxacin answer

Can you take Hemp Agrimony with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA).

Full Hemp Agrimony + Moxifloxacin answer

Can you take Iboga with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, iboga may have an additive effect with drugs that prolong the QT interval.

Full Iboga + Moxifloxacin answer

Can you take K2/spice with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, K2/spice might have an additive effect with drugs that prolong the QT interval and increase the risk of ventricular arrhythmi...

Full K2/spice + Moxifloxacin answer

Can you take Kava with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using kava with hepatotoxic drugs might increase the risk of liver damage.

Full Kava + Moxifloxacin answer

Can you take Khella with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might result in increased photosensitivity.

Full Khella + Moxifloxacin answer

Can you take Kudzu with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Kudzu + Moxifloxacin answer

Can you take Ligandrol with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Ligandrol + Moxifloxacin answer

Can you take Light Therapy with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Light therapy may increase the risk for photosensitization.

Full Light Therapy + Moxifloxacin answer

Can you take Lime with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.

Full Lime + Moxifloxacin answer

Can you take Manchurian Thorn with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that high doses of Manchurian thorn can induce liver damage.

Full Manchurian Thorn + Moxifloxacin answer

Can you take Melatonin with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Moxifloxacin answer

Can you take Methoxylated Flavones with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, methoxylated flavones inhibit organic anion transporting polypeptide (OATP) 1B1, 1B3, and 2B1.

Full Methoxylated Flavones + Moxifloxacin answer

Can you take Mountain Ash with Moxifloxacin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent.

Full Mountain Ash + Moxifloxacin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Moxifloxacin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Moxifloxacin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Moxifloxacin sits in 9 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Moxifloxacin through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Moxifloxacin through this category.

Quinolone Antibiotics 24 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

24 of the supplement ingredients on this page reach Moxifloxacin through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Moxifloxacin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Moxifloxacin through this category.

Organic Anion-Transporting Polypeptide Substrates (Oatp) 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Moxifloxacin through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Moxifloxacin through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Moxifloxacin through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Moxifloxacin through this category.

About Moxifloxacin

Moxifloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, skin, and abdominal infections.

Generic name: Moxifloxacin  ·  Brand name: Avelox.

See the full Moxifloxacin drug information

Related: does Moxifloxacin deplete any nutrients?

Moxifloxacin has 11 reported nutrient associations in the research literature — see the Moxifloxacin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Moxifloxacin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Moxifloxacin.

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Pharmacist Counseling Corner

Moxifloxacin & Supplements: Common Questions

What supplements interact with Moxifloxacin?
More than you might expect — 155 in total, though they are far from equal: 13 are rated major, 121 moderate, and 21 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Apple, Grapefruit, Siberian Cocklebur.
Which Moxifloxacin supplement interactions are the most serious?
Focus on the major group: Apple, Grapefruit, Siberian Cocklebur, Sweet Orange and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Moxifloxacin?
Usually yes — most people on Moxifloxacin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Avelox have the same supplement interactions as Moxifloxacin?
Yes — Avelox all contain Moxifloxacin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Moxifloxacin deplete any vitamins or nutrients?
It might — Moxifloxacin has 11 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Moxifloxacin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Moxifloxacin and my other medications?
This page covers Moxifloxacin against supplements and herbal ingredients. Checking Moxifloxacin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Moxifloxacin drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.