Drug & supplement interaction

Lactiplantibacillus Pentosus + Amoxicillin

Amoxicillin brand names: Amoxil Capsules, Trimox, Wymox, Amix, Amoram, and others.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Lactiplantibacillus Pentosus has a moderate interaction with Amoxicillin. Theoretically, taking Lactiplantibacillus pentosus with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Lactiplantibacillus Pentosus and Amoxicillin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIBIOTIC DRUGS

Why this applies to Amoxicillin

Amoxicillin falls under ANTIBIOTIC DRUGS — the group Lactiplantibacillus Pentosus interacts with.

Theoretically, taking Lactiplantibacillus pentosus with antibiotic drugs might decrease the effectiveness of L. pentosus.
Lactiplantibacillus pentosus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. pentosus preparations by at least two hours.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to keep in mind: amoxicillin is designed to kill bacteria, and the probiotic in Lactiplantibacillus pentosus supplements is bacteria, the friendly kind. If you swallow them at the same time, your antibiotic can wipe out a good chunk of those live probiotic organisms before they ever get to work. So this isn't about amoxicillin becoming dangerous or less effective at treating your infection. It's the probiotic that loses out.

This is a theoretical concern based on how these two work, not something proven in big studies, so don't stress over it. A simple fix is to space them apart by at least two hours. Many folks actually take a probiotic to ease antibiotic-related diarrhea, which is reasonable. If you're not sure how to time things, your pharmacist can help you map it out.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Lactiplantibacillus Pentosus Also Interacts With Other Medications

Lactiplantibacillus Pentosus has 181 moderate known drug interactions in our database — the Amoxicillin one above is one of them. If you take anything else, check it against the full list below.

Moderate 181 No known interaction 2,649 (incl. Amoxicillin)
Taking anything else?

Check Another of Your Medications Against Lactiplantibacillus Pentosus

Covers the 2,830 medications we’ve checked against Lactiplantibacillus Pentosus. Pick one to open its full report.

From our Q&A

Questions About Lactiplantibacillus Pentosus or Amoxicillin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Lactiplantibacillus Pentosus or Amoxicillin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Amoxicillin

This page covers Lactiplantibacillus Pentosus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amoxicillin page lists 96 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Khat (major) and Siberian Cocklebur (major).

By severity: 6 major · 76 moderate · 14 minor.

From our pharmacist’s overview on the Amoxicillin page

“Amoxicillin, one of the most commonly prescribed antibiotics, has 96 supplement and herbal ingredients flagged against it, and six carry a major rating, which puts this list in the read-carefully category. The serious entries mostly add strain to organs the drug already touches.”

Reviewed by 2 · Jul 18, 2026

Open the Amoxicillin interaction page

How much people look this up

Where Lactiplantibacillus Pentosus and Amoxicillin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lactiplantibacillus Pentosus
Steady interest

#1,220 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amoxicillin
Top 5%

#35 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Lactiplantibacillus Pentosus

What is Lactiplantibacillus Pentosus?

  • Digestive and gut health
  • Immune support
  • Maintaining a healthy gut microbiome
  • Fermentation of foods (such as olives and vegetables)

Lactiplantibacillus pentosus is a 'friendly' probiotic bacterium found in many fermented foods and used in some supplements for gut and immune health. Research is still early, so it is not proven to treat any specific condition. It is generally considered safe for healthy adults, but people with weakened immune systems or serious illness should talk to a doctor first.

Read the full Lactiplantibacillus Pentosus monograph & all interactions
Medication

About Amoxicillin

What Is Amoxicillin Used For?

Brand names: Amoxil Capsules, Trimox, Wymox, Amix, Amoram, Amoxident, Galenamox, Rimoxallin, Amoxil Injection

Amoxicillin treats bacterial infections in both adults and children, including ear, nose, and throat infections; lower respiratory tract infections; skin and skin structure infections; and genitourinary tract infections.

In adults only, amoxicillin is also used — always combined with other medications — to eradicate Helicobacter pylori (H. pylori), the bacteria behind duodenal ulcers. Getting rid of H. pylori has been shown to reduce the chance of those ulcers coming back. It is only effective against bacteria that are susceptible to it and will not work against viral infections like the common cold or flu.

See full Amoxicillin drug information
Keep checking

Other Drugs & Lactiplantibacillus Pentosus

Browse every other medication we’ve checked against Lactiplantibacillus Pentosus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
181Moderate
0Minor
2,648No known interaction
181 Moderate 2,648 No interaction
Moderate

181 interactions

Showing 60 of 181 moderate interactions — see all 181 on the Lactiplantibacillus Pentosus page.

No interaction 2,648 drugs checked — show the list

We also checked Lactiplantibacillus Pentosus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,648 medications checked with no known interaction — see the full Lactiplantibacillus Pentosus list.

See the full Lactiplantibacillus Pentosus interactions page
See every supplement checked against Amoxicillin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Lactiplantibacillus Pentosus monograph › Uses, safety, and every drug interaction in one place Amoxicillin supplement interactions › Every supplement checked against Amoxicillin, ranked by severity Amoxicillin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Lactiplantibacillus Pentosus and Amoxicillin Together: Common Questions

Can you take Lactiplantibacillus Pentosus with Amoxicillin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Lactiplantibacillus Pentosus and Amoxicillin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Amoxicillin and Lactiplantibacillus Pentosus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.