Drug & supplement interaction

Lactiplantibacillus Plantarum + Oritavancin Diphosphate

Oritavancin Diphosphate brand names: Orbactiv, Kimyrsa.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Lactiplantibacillus Plantarum has a moderate interaction with Oritavancin Diphosphate. Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Lactiplantibacillus Plantarum and Oritavancin Diphosphate

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIBIOTIC DRUGS

Why this applies to Oritavancin Diphosphate

Oritavancin Diphosphate falls under ANTIBIOTIC DRUGS — the group Lactiplantibacillus Plantarum interacts with.

Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L. plantarum.
L. plantarum preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. plantarum preparations by at least two hours.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: oritavancin is a powerful antibiotic given as a single IV infusion to treat skin infections, and it works by killing bacteria. The catch is that your L. plantarum probiotic is made of live, friendly bacteria. An antibiotic doesn't know the difference between good and bad bugs, so it can wipe out many of the probiotic organisms too. That means the probiotic just may not do much for you while the antibiotic is working.

The good news is this goes in one direction only. The probiotic does not make oritavancin weaker or more toxic, so your infection treatment isn't put at risk. This concern is theoretical and based on how these products work. If you want to keep taking the probiotic, ask your pharmacist about timing, since oritavancin sticks around in the body for a long time after the infusion.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Lactiplantibacillus Plantarum Also Interacts With Other Medications

Lactiplantibacillus Plantarum has 181 moderate known drug interactions in our database — the Oritavancin Diphosphate one above is one of them. If you take anything else, check it against the full list below.

Moderate 181 No known interaction 2,649 (incl. Oritavancin Diphosphate)
Taking anything else?

Check Another of Your Medications Against Lactiplantibacillus Plantarum

Covers the 2,830 medications we’ve checked against Lactiplantibacillus Plantarum. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Oritavancin Diphosphate

This page covers Lactiplantibacillus Plantarum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Oritavancin Diphosphate page lists 48 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Alkanna (moderate), Alpine Ragwort (moderate), Bacillus Coagulans (moderate), Bacillus Subtilis (moderate) and Bifidobacterium Animalis Subsp. Lactis (moderate).

By severity: 47 moderate · 1 minor.

From our pharmacist’s overview on the Oritavancin Diphosphate page

“Oritavancin (Orbactiv, Kimyrsa) is a long-acting antibiotic given as a single IV infusion for serious skin infections, and because one dose stays in the body for days, supplement timing matters more than usual. Even so, none of the 48 ingredients on file rise past moderate, so for most people this list is about knowing what to watch ra…”

Reviewed by 2 · Jul 18, 2026

Open the Oritavancin Diphosphate interaction page

How much people look this up

Where Lactiplantibacillus Plantarum and Oritavancin Diphosphate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lactiplantibacillus Plantarum
Top half

#617 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Oritavancin Diphosphate
Steady interest

#2,790 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Lactiplantibacillus Plantarum

What is Lactiplantibacillus Plantarum?

  • Digestive health and regularity
  • Irritable bowel syndrome (IBS) symptoms
  • Bloating and gas
  • Immune support
  • Restoring gut bacteria after antibiotics

Lactiplantibacillus plantarum is a 'friendly' bacterium (probiotic) found in fermented foods and many supplements, studied mainly for digestive health. It is generally well tolerated in healthy people, but evidence is mixed and strain-specific, so benefits are not guaranteed. Talk to your pharmacist or doctor before starting, especially if you have a weakened immune system.

Read the full Lactiplantibacillus Plantarum monograph & all interactions
Medication

About Oritavancin Injection

What Is Oritavancin Injection Used For?

Brand names: Orbactiv, Kimyrsa

Oritavancin is an antibiotic used for acute bacterial skin and skin structure infections (ABSSSI) in adults. These are infections caused by certain susceptible Gram-positive bacteria.

The Orbactiv label lists these bacteria: Staphylococcus aureus (including MRSA), several Streptococcus species, and Enterococcus faecalis (vancomycin-susceptible only). Like all antibiotics, it should be used only for infections that are proven or strongly suspected to be bacterial.

See full Oritavancin Injection drug information
Keep checking

Other Drugs & Lactiplantibacillus Plantarum

Browse every other medication we’ve checked against Lactiplantibacillus Plantarum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
181Moderate
0Minor
2,648No known interaction
181 Moderate 2,648 No interaction
Moderate

181 interactions

Showing 60 of 181 moderate interactions — see all 181 on the Lactiplantibacillus Plantarum page.

No interaction 2,648 drugs checked — show the list

We also checked Lactiplantibacillus Plantarum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,648 medications checked with no known interaction — see the full Lactiplantibacillus Plantarum list.

See the full Lactiplantibacillus Plantarum interactions page
See every supplement checked against Oritavancin Diphosphate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Lactiplantibacillus Plantarum monograph › Uses, safety, and every drug interaction in one place Oritavancin Diphosphate supplement interactions › Every supplement checked against Oritavancin Diphosphate, ranked by severity Oritavancin Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Lactiplantibacillus Plantarum and Oritavancin Diphosphate Together: Common Questions

Can you take Lactiplantibacillus Plantarum with Oritavancin Diphosphate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Lactiplantibacillus Plantarum and Oritavancin Diphosphate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Oritavancin Diphosphate and Lactiplantibacillus Plantarum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.