Medication interaction hub

What Supplements Interact with Oritavancin Diphosphate?

Oritavancin Diphosphate brand names: Orbactiv, Kimyrsa. Every interaction below applies to the brands too.

48 Interactions 47 Moderate 1 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Oritavancin Diphosphate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Oritavancin Diphosphate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Oritavancin (Orbactiv, Kimyrsa) is a long-acting antibiotic given as a single IV infusion for serious skin infections, and because one dose stays in the body for days, supplement timing matters more than usual. Even so, none of the 48 ingredients on file rise past moderate, so for most people this list is about knowing what to watch rather than what to avoid. More than half the entries are probiotics, from Lactobacillus acidophilus to fermented milk products, and the concern runs the other way: the antibiotic can kill those live organisms and blunt their benefit, so space probiotic doses well apart from the infusion.

The rest of the list works through liver enzymes. Nineteen ingredients rev up CYP3A4 and a few slow CYP2C9 or CYP2C19, which can change how medications are processed. Only one of the 48 rates minor; the other 47 sit at moderate, none higher.

— , Clinical Pharmacist · July 18, 2026

Moderate 47 Minor 1 No known interaction 1,404

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Oritavancin Diphosphate: Top Interactions at a Glance

The most significant Oritavancin Diphosphate supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 48 interacting ingredients — plus 1,404 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant Oritavancin Diphosphate + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Probable Bacillus Coagulans + Oritavancin Diphosphatei

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Bacillus Subtilis + Oritavancin Diphosphatei

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Animalis Subsp. Lactis + Oritavancin Diphosphatei

Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Bifidum + Oritavancin Diphosphatei

Theoretically, taking Bifidobacterium.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Breve + Oritavancin Diphosphatei

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Longum + Oritavancin Diphosphatei

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction
The complete list

Every Supplement Checked Against Oritavancin Diphosphate

All 1,452 ingredients in our database, ranked by severity — 48 with a Oritavancin Diphosphate interaction on file and 1,404 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Oritavancin Diphosphate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Alkanna with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hepatotoxic pyrrolizidine alkaloids (PAs) are substrates of cytochrome P450 3A4 (CYP3A4).

Full Alkanna + Oritavancin Diphosphate answer

Can you take Fermented Milk with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotic drugs might decrease the effectiveness of fermented milk.

Full Fermented Milk + Oritavancin Diphosphate answer

Can you take Lacticaseibacillus Casei with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus casei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Casei + Oritavancin Diphosphate answer

Can you take Lacticaseibacillus Paracasei with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus paracasei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Paracasei + Oritavancin Diphosphate answer

Can you take Lacticaseibacillus Rhamnosus with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus rhamnosus with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Rhamnosus + Oritavancin Diphosphate answer

Can you take Lactiplantibacillus Pentosus with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactiplantibacillus pentosus with antibiotic drugs might decrease the effectiveness of L.

Full Lactiplantibacillus Pentosus + Oritavancin Diphosphate answer

Can you take Lactiplantibacillus Plantarum with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Full Lactiplantibacillus Plantarum + Oritavancin Diphosphate answer

Can you take Lactobacillus Acidophilus with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Acidophilus + Oritavancin Diphosphate answer

Can you take Lactobacillus Crispatus with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus crispatus with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Crispatus + Oritavancin Diphosphate answer

Can you take Lactobacillus Delbrueckii with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Delbrueckii + Oritavancin Diphosphate answer

Can you take Lactobacillus Gasseri with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus gasseri with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Gasseri + Oritavancin Diphosphate answer

Can you take Lactobacillus Helveticus with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus helveticus with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Helveticus + Oritavancin Diphosphate answer

Can you take Lactobacillus Jensenii with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus jensenii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Jensenii + Oritavancin Diphosphate answer

Can you take Lactobacillus Johnsonii with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus johnsonii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Johnsonii + Oritavancin Diphosphate answer

Can you take Latilactobacillus Sakei with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Latilactobacillus sakei with antibiotic drugs might decrease the effectiveness of L.

Full Latilactobacillus Sakei + Oritavancin Diphosphate answer

Can you take Levilactobacillus Brevis with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Levilactobacillus brevis with antibiotic drugs might decrease the effectiveness of L.

Full Levilactobacillus Brevis + Oritavancin Diphosphate answer

Can you take Ligilactobacillus Salivarius with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Ligilactobacillus salivarius with antibiotic drugs might decrease the effectiveness of L.

Full Ligilactobacillus Salivarius + Oritavancin Diphosphate answer

Can you take Limosilactobacillus Fermentum with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Limosilactobacillus fermentum with antibiotic drugs might decrease the effectiveness of L.

Full Limosilactobacillus Fermentum + Oritavancin Diphosphate answer

Can you take Limosilactobacillus Reuteri with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Limosilactobacillus reuteri with antibiotic drugs might decrease the effectiveness of L.

Full Limosilactobacillus Reuteri + Oritavancin Diphosphate answer

Can you take Probiotics with Oritavancin Diphosphate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking antibiotic drugs with certain probiotics might decrease the effectiveness of probiotics.

Full Probiotics + Oritavancin Diphosphate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Oritavancin Diphosphate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Oritavancin Diphosphate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Oritavancin Diphosphate sits in 4 interaction categories. Open any one to see what the group means:

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Oritavancin Diphosphate through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Oritavancin Diphosphate through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Oritavancin Diphosphate through this category.

Cytochrome P450 2C19 (Cyp2C19) Inhibitors 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Oritavancin Diphosphate through this category.

About Oritavancin Diphosphate

Oritavancin injection is an antibacterial medicine used to treat acute bacterial skin and skin structure infections caused by certain gram-positive bacteria, available as Kimyrsa and Orbactiv.

Generic name: Oritavancin Diphosphate  ·  Brand names: Orbactiv, Kimyrsa.

See the full Oritavancin Injection drug information

Related: does Oritavancin Diphosphate deplete any nutrients?

Oritavancin Diphosphate has 14 reported nutrient associations in the research literature — see the Oritavancin Diphosphate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Oritavancin Diphosphate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Oritavancin Diphosphate.

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Pharmacist Counseling Corner

Oritavancin Diphosphate & Supplements: Common Questions

What supplements interact with Oritavancin Diphosphate?
In our interaction database, 48 supplement and herbal ingredients have an interaction with Oritavancin Diphosphate on file — 0 rated major, 47 moderate, and 1 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Bacillus Coagulans, Bacillus Subtilis, Bifidobacterium Animalis Subsp. Lactis.
Which Oritavancin Diphosphate supplement interactions are the most serious?
None of the Oritavancin Diphosphate supplement interactions on file are currently rated major. The most significant are the 47 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Oritavancin Diphosphate?
That depends entirely on which supplement. The honest answer for Oritavancin Diphosphate is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Orbactiv have the same supplement interactions as Oritavancin Diphosphate?
Yes — Orbactiv, Kimyrsa all contain Oritavancin Diphosphate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Oritavancin Diphosphate deplete any vitamins or nutrients?
It might — Oritavancin Diphosphate has 14 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Oritavancin Diphosphate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Oritavancin Diphosphate and my other medications?
This page covers Oritavancin Diphosphate against supplements and herbal ingredients. Checking Oritavancin Diphosphate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Oritavancin Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.