Medication interaction hub

What Supplements Interact with Cannabidiol (prescription drug)?

Cannabidiol (prescription drug) brand name: Epidiolex. Every interaction below applies to the brands too.

234 Interactions 10 Major 184 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated September 29, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Cannabidiol (prescription drug)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Cannabidiol (prescription drug) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Epidiolex, the prescription form of cannabidiol used for severe seizure disorders, is not a drug I would casually mix with supplements; ten of the 234 ingredients on this page carry a major rating. Some change how the liver processes cannabidiol, so grapefruit can push its levels up while St. John's wort can drain them low enough to threaten seizure control. Sedating products, alcohol chief among them, add drowsiness to a medicine already known for it, and 38 herbs on the list can stress the liver, which matters because Epidiolex itself can raise liver enzymes.

The remaining 184 moderate and 40 minor entries are mostly quieter versions of those same problems, along with a small group that can blunt absorption of oral doses and belongs spaced well apart. Learn the majors first, because for someone with epilepsy, a swing in cannabidiol levels can mean breakthrough seizures, not just extra side effects.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 184 Minor 40 No known interaction 1,218

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Cannabidiol (prescription drug): Top Interactions at a Glance

The most significant Cannabidiol (prescription drug) supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 234 interacting ingredients — plus 1,218 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Cannabidiol (prescription drug) + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Cannabidiol (prescription drug)i

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Grapefruit + Cannabidiol (prescription drug)i

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Cannabidiol (prescription drug)i

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Likely Wine + Cannabidiol (prescription drug)i

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Cannabidiol (prescription drug)i

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Cannabidiol (prescription drug)i

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Cannabidiol (prescription drug)

All 1,452 ingredients in our database, ranked by severity — 234 with a Cannabidiol (prescription drug) interaction on file and 1,218 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Cannabidiol (prescription drug)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Caffeine with Cannabidiol (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Caffeine + Cannabidiol (prescription drug) answer

Can you take Boswellia Serrata with Cannabidiol (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.

Full Boswellia Serrata + Cannabidiol (prescription drug) answer

Can you take Garlic with Cannabidiol (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.

Full Garlic + Cannabidiol (prescription drug) answer

Can you take Calendula with Cannabidiol (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.

Full Calendula + Cannabidiol (prescription drug) answer

Can you take Eleuthero with Cannabidiol (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.

Full Eleuthero + Cannabidiol (prescription drug) answer

Can you take Gamma-aminobutyric Acid (gaba) with Cannabidiol (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.

Full Gamma-aminobutyric Acid (gaba) + Cannabidiol (prescription drug) answer

Can you take Gymnema with Cannabidiol (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.

Full Gymnema + Cannabidiol (prescription drug) answer

Can you take Humann Superbeets Heart Chews with Cannabidiol (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 150mg of grape seed extract (2 chews).

Full Humann Superbeets Heart Chews + Cannabidiol (prescription drug) answer

Can you take Jequirity with Cannabidiol (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Full Jequirity + Cannabidiol (prescription drug) answer

Can you take Milk Thistle with Cannabidiol (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if milk thistle inhibits CYP3A4; research is conflicting.

Full Milk Thistle + Cannabidiol (prescription drug) answer

Can you take Mommy's Bliss Gripe Water with Cannabidiol (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Mommy's Bliss Gripe Water contains fennel seed.

Full Mommy's Bliss Gripe Water + Cannabidiol (prescription drug) answer

Can you take Polypodium Leucotomos with Cannabidiol (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.

Full Polypodium Leucotomos + Cannabidiol (prescription drug) answer

Can you take Pomegranate with Cannabidiol (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to...

Full Pomegranate + Cannabidiol (prescription drug) answer

Can you take Red Clover with Cannabidiol (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, red clover might increase the levels and clinical effects of drugs metabolized by CYP2C19.

Full Red Clover + Cannabidiol (prescription drug) answer

Can you take Tangerine with Cannabidiol (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).

Full Tangerine + Cannabidiol (prescription drug) answer

Can you take Theanine with Cannabidiol (prescription drug)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants.

Full Theanine + Cannabidiol (prescription drug) answer

Can you take Beer with Cannabidiol (prescription drug)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase sedative and other adverse effects.

Full Beer + Cannabidiol (prescription drug) answer

Can you take Grapefruit with Cannabidiol (prescription drug)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Cannabidiol (prescription drug) answer

Can you take Siberian Cocklebur with Cannabidiol (prescription drug)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Siberian cocklebur can adversely affect the liver.

Full Siberian Cocklebur + Cannabidiol (prescription drug) answer

Can you take Wine with Cannabidiol (prescription drug)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase sedative and other adverse effects.

Full Wine + Cannabidiol (prescription drug) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Cannabidiol (prescription drug) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Cannabidiol (prescription drug), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Cannabidiol (prescription drug) sits in 8 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Cannabidiol (prescription drug) through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Cannabidiol (prescription drug) through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Cannabidiol (prescription drug) through this category.

Cytochrome P450 2C19 (Cyp2C19) Substrates 33 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

33 of the supplement ingredients on this page reach Cannabidiol (prescription drug) through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Cannabidiol (prescription drug) through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Cannabidiol (prescription drug) through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Cannabidiol (prescription drug) through this category.

Cytochrome P450 2C19 (Cyp2C19) Inhibitors 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Cannabidiol (prescription drug) through this category.

About Cannabidiol (prescription drug)

Cannabidiol is a cannabinoid medication used to control seizures in people with Lennox-Gastaut syndrome, Dravet syndrome, or tuberous sclerosis complex.

Generic name: Cannabidiol (prescription drug)  ·  Brand name: Epidiolex.

See the full Cannabidiol drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Cannabidiol (prescription drug)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Cannabidiol (prescription drug).

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Pharmacist Counseling Corner

Cannabidiol (prescription drug) & Supplements: Common Questions

What supplements interact with Cannabidiol (prescription drug)?
Our database currently documents 234 ingredients with a known Cannabidiol (prescription drug) interaction (10 major, 184 moderate, 40 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 234. The highest-ranked right now: Beer, Grapefruit, Siberian Cocklebur.
Which Cannabidiol (prescription drug) supplement interactions are the most serious?
Focus on the major group: Beer, Grapefruit, Siberian Cocklebur, Wine and 1,4-butanediol, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Cannabidiol (prescription drug)?
Plenty of supplements coexist fine with Cannabidiol (prescription drug); a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Epidiolex have the same supplement interactions as Cannabidiol (prescription drug)?
Yes — Epidiolex all contain Cannabidiol (prescription drug), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Cannabidiol (prescription drug) and my other medications?
This page covers Cannabidiol (prescription drug) against supplements and herbal ingredients. Checking Cannabidiol (prescription drug) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Cannabidiol drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 29, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.