Medication interaction hub

What Supplements Interact with Vemurafenib?

Vemurafenib brand name: Zelboraf. Every interaction below applies to the brands too.

165 Interactions 8 Major 118 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Vemurafenib? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Vemurafenib against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

People taking vemurafenib (Zelboraf) for BRAF-positive melanoma often reach for immune boosters, herbal blends, and green teas, and this is one drug where those choices deserve real scrutiny before anything gets combined. Of the 165 supplement ingredients with an interaction on file, 8 are rated major, and the biggest cluster (121 ingredients) ties back to the CYP3A4 enzyme that clears the drug. St. John's wort can drain vemurafenib's level by speeding that enzyme up, while grapefruit does the reverse and can push levels higher.

A second cluster matters because vemurafenib can already disturb the heart's rhythm; 13 of these ingredients also prolong the QT interval, ephedra and non-prescription arsenic among them. A smaller group, activated charcoal and thick fibers like glucomannan, can blunt absorption of the dose itself. Read the 8 majors first; the 118 moderates and 39 minors mostly echo the same themes at lower intensity.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 118 Minor 39 No known interaction 1,287

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Vemurafenib: Top Interactions at a Glance

The Vemurafenib supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 165 interacting ingredients — plus 1,287 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Vemurafenib Combinations Today

The Vemurafenib + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Probable St. John's Wort + Vemurafenibi

St.

Read the full interaction Moderate Likelihood Possible Vitamin E + Vemurafenibi

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Cubebs + Vemurafenibi

Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Read the full interaction Moderate Likelihood Possible Goldthread + Vemurafenibi

There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Read the full interaction Major Likelihood Likely Grapefruit + Vemurafenibi

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Activated Charcoal + Vemurafenibi

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Vemurafenib

All 1,452 ingredients in our database, ranked by severity — 165 with a Vemurafenib interaction on file and 1,287 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Vemurafenib?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take St. John's Wort with Vemurafenib?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Vemurafenib answer

Can you take Vitamin E with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Vemurafenib answer

Can you take Cubebs with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Cubebs + Vemurafenib answer

Can you take Goldthread with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Vemurafenib answer

Can you take Ceylon Leadwort with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Ceylon Leadwort + Vemurafenib answer

Can you take Chanca Piedra with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.

Full Chanca Piedra + Vemurafenib answer

Can you take Chokeberry with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.

Full Chokeberry + Vemurafenib answer

Can you take Cinchona with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cinchona with other QT interval-prolonging drugs might cause an additive effect and increase the risk of ventricular a...

Full Cinchona + Vemurafenib answer

Can you take Clove with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.

Full Clove + Vemurafenib answer

Can you take Cocoa with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Cocoa + Vemurafenib answer

Can you take Cola Nut with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP1A2 inhibitors might increase the levels and adverse effects of the caffeine in cola nut.

Full Cola Nut + Vemurafenib answer

Can you take Coleus with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.

Full Coleus + Vemurafenib answer

Can you take Corydalis Yanhusuo with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP3A4.

Full Corydalis Yanhusuo + Vemurafenib answer

Can you take Cranberry with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + Vemurafenib answer

Can you take Danshen with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Danshen might alter the levels and clinical effects of drugs metabolized by CYP3A4.

Full Danshen + Vemurafenib answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of THC.

Full Delta-9-tetrahydrocannabinol (thc) + Vemurafenib answer

Can you take Devil's Claw with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Vemurafenib answer

Can you take Dhea with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Vemurafenib answer

Can you take Diosmin with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Full Diosmin + Vemurafenib answer

Can you take Echinacea with Vemurafenib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Full Echinacea + Vemurafenib answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Vemurafenib is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Vemurafenib, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Vemurafenib sits in 9 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Vemurafenib through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Vemurafenib through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Vemurafenib through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Vemurafenib through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Vemurafenib through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Vemurafenib through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Vemurafenib through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Vemurafenib through this category.

Cytochrome P450 2C19 (Cyp2C19) Inhibitors 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Vemurafenib through this category.

About Vemurafenib

Vemurafenib is a targeted cancer medicine used to treat certain types of melanoma (skin cancer) and a rare disease called Erdheim-Chester Disease, in patients whose tumors carry a specific BRAF gene mutation.

Generic name: Vemurafenib  ·  Brand name: Zelboraf.

See the full Vemurafenib drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Vemurafenib

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Vemurafenib.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Vemurafenib & Supplements: Common Questions

What supplements interact with Vemurafenib?
Our database currently documents 165 ingredients with a known Vemurafenib interaction (8 major, 118 moderate, 39 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 165. The highest-ranked right now: Grapefruit, Activated Charcoal, Arsenic.
Which Vemurafenib supplement interactions are the most serious?
The 8 major-rated combinations — led by Grapefruit, Activated Charcoal, Arsenic, Cesium and Ephedra — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Vemurafenib?
Plenty of supplements coexist fine with Vemurafenib; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Zelboraf have the same supplement interactions as Vemurafenib?
Yes — Zelboraf all contain Vemurafenib, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Vemurafenib and my other medications?
This page covers Vemurafenib against supplements and herbal ingredients. Checking Vemurafenib against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Vemurafenib drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.