Medication interaction hub

What Supplements Interact with Cimetidine?

Cimetidine brand names: Tagamet HB, Tagamet, Cimetidine Injection. Every interaction below applies to the brands too.

95 Interactions 3 Major 63 Moderate 29 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Cimetidine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Cimetidine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

95 supplements and herbal ingredients have interactions with Cimetidine on file in the HelloPharmacist interaction database — 3 rated major, 63 moderate, and 29 minor. The most serious involve Pu-erh Tea, Activated Charcoal and St. John's Wort.

Our assessment: with 3 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Cimetidine.

Major 3 Moderate 63 Minor 29 No known interaction 1,357

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Cimetidine: Top Interactions at a Glance

The Cimetidine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 95 interacting ingredients — plus 1,357 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Cimetidine Combinations Today

The Cimetidine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Betaine Hydrochloride + Cimetidinei

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.

Read the full interaction Minor Likelihood Possible Blessed Thistle + Cimetidinei

Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.

Read the full interaction Minor Likelihood Possible Devil's Claw + Cimetidinei

Theoretically, devil's claw might increase levels of P-glycoprotein substrates.

Read the full interaction Moderate Likelihood Possible Cola Nut + Cimetidinei

Theoretically, CYP1A2 inhibitors might increase the levels and adverse effects of the caffeine in cola nut.

Read the full interaction Minor Likelihood Possible Aletris + Cimetidinei

Theoretically, due to reports that aletris increases stomach acid, aletris might decrease the effectiveness of H2-blockers.

Read the full interaction Moderate Likelihood Possible Ergot + Cimetidinei

Ergotamine, a constituent of ergot, is a substrate of cytochrome P450 3A4 (CYP3A4).

Read the full interaction
The complete list

Every Supplement Checked Against Cimetidine

All 1,452 ingredients in our database, ranked by severity — 95 with a Cimetidine interaction on file and 1,357 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Cimetidine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Betaine Hydrochloride with Cimetidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.

Full Betaine Hydrochloride + Cimetidine answer

Can you take Blessed Thistle with Cimetidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.

Full Blessed Thistle + Cimetidine answer

Can you take Devil's Claw with Cimetidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, devil's claw might increase levels of P-glycoprotein substrates.

Full Devil's Claw + Cimetidine answer

Can you take Cola Nut with Cimetidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP1A2 inhibitors might increase the levels and adverse effects of the caffeine in cola nut.

Full Cola Nut + Cimetidine answer

Can you take Aletris with Cimetidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, due to reports that aletris increases stomach acid, aletris might decrease the effectiveness of H2-blockers.

Full Aletris + Cimetidine answer

Can you take Goldenseal with Cimetidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase or decrease serum levels of P-glycoprotein (P-gp) substrates.

Full Goldenseal + Cimetidine answer

Can you take Yohimbe with Cimetidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.

Full Yohimbe + Cimetidine answer

Can you take Adrafinil with Cimetidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, drugs that inhibit CYP3A4 might increase the levels and clinical effects of adrafinil.

Full Adrafinil + Cimetidine answer

Can you take African Wild Potato with Cimetidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that African wild potato extract inhibits OAT1.

Full African Wild Potato + Cimetidine answer

Can you take Banderol with Cimetidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Small lab studies have found that Banderol may inhibit OATP1B1 (Organic Anion Transporting Polypeptide 1B1), which is a membrane protein res...

Full Banderol + Cimetidine answer

Can you take Beer with Cimetidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use might increase blood alcohol levels and adverse effects.

Full Beer + Cimetidine answer

Can you take Bitter Melon with Cimetidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter melon might increase levels of P-glycoprotein substrates.

Full Bitter Melon + Cimetidine answer

Can you take Black Pepper with Cimetidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of P-glycoprotein substrates.

Full Black Pepper + Cimetidine answer

Can you take Bulbine Natalensis with Cimetidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might increase the levels and clinical effects of p-glycoprotein substrates.

Full Bulbine Natalensis + Cimetidine answer

Can you take Caffeic Acid with Cimetidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeic acid might increase the levels and clinical effects of OAT1 substrates.

Full Caffeic Acid + Cimetidine answer

Can you take Cannabidiol (cbd) with Cimetidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase cannabidiol levels.

Full Cannabidiol (cbd) + Cimetidine answer

Can you take Cannabinol (cbn) with Cimetidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of cannabinol.

Full Cannabinol (cbn) + Cimetidine answer

Can you take Cannabis with Cimetidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of cannabis.

Full Cannabis + Cimetidine answer

Can you take Clay with Cimetidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical research suggests that clay might inhibit the absorption of cimetidine when taken simultaneously.

Full Clay + Cimetidine answer

Can you take Cocoa with Cimetidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Cocoa + Cimetidine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Cimetidine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Cimetidine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Cimetidine sits in 9 interaction categories. Open any one to see what the group means:

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Cimetidine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Cimetidine through this category.

H2-Blockers 14 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

14 of the supplement ingredients on this page reach Cimetidine through this category.

Cimetidine (Tagamet) 13 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

13 of the supplement ingredients on this page reach Cimetidine through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Cimetidine through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Cimetidine through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Cimetidine through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Cimetidine through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Cimetidine through this category.

About Cimetidine

Cimetidine is an H2 blocker used to treat ulcers, acid reflux, heartburn, and conditions where the stomach produces too much acid.

Generic name: Cimetidine  ·  Brand names: Tagamet HB, Tagamet, Cimetidine Injection.

See the full Cimetidine drug information

Related: does Cimetidine deplete any nutrients?

Cimetidine has 21 reported nutrient associations in the research literature — see the Cimetidine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Cimetidine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Cimetidine.

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Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Cimetidine & Supplements: Common Questions

What supplements interact with Cimetidine?
Our database currently documents 95 ingredients with a known Cimetidine interaction (3 major, 63 moderate, 29 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 95. The highest-ranked right now: Pu-erh Tea, Activated Charcoal, St. John's Wort.
Which Cimetidine supplement interactions are the most serious?
The 3 major-rated combinations — led by Pu-erh Tea, Activated Charcoal and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Cimetidine?
Plenty of supplements coexist fine with Cimetidine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Tagamet HB have the same supplement interactions as Cimetidine?
Yes — Tagamet HB, Tagamet, Cimetidine Injection all contain Cimetidine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Cimetidine deplete any vitamins or nutrients?
It might — Cimetidine has 21 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Cimetidine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Cimetidine and my other medications?
This page covers Cimetidine against supplements and herbal ingredients. Checking Cimetidine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Cimetidine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.