Medication interaction hub

What Supplements Interact with Berotralstat Hydrochloride?

Berotralstat Hydrochloride brand name: Orladeyo. Every interaction below applies to the brands too.

75 Interactions 8 Major 51 Moderate 16 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Berotralstat Hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Berotralstat Hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you take berotralstat (Orladeyo) to prevent hereditary angioedema attacks, this list deserves real attention, and the eight major-rated entries are where to start. The biggest cluster, 37 ingredients, affects the gut pump that moves berotralstat into your body; St. John's wort can drive its level down far enough to leave you underprotected against swelling attacks. Thirteen more, grapefruit among them, can stretch the heart's electrical rhythm, a risk that grows if anything nudges berotralstat's own level higher.

Activated charcoal leads a group of 17 that can block oral drugs from absorbing at all, so keep those well away from your dose. Fifty-one entries rate moderate and 16 minor, and several of the moderates run in reverse, with berotralstat raising the supplement's level rather than the supplement changing yours. With a drug you count on to stop swelling attacks, screen each supplement before you start it.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 51 Minor 16 No known interaction 1,377

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Berotralstat Hydrochloride: Top Interactions at a Glance

The Berotralstat Hydrochloride supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 75 interacting ingredients — plus 1,377 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Berotralstat Hydrochloride Combinations Today

The Berotralstat Hydrochloride + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Devil's Claw + Berotralstat Hydrochloridei

Theoretically, devil's claw might increase levels of P-glycoprotein substrates.

Read the full interaction Major Likelihood Probable Grapefruit + Berotralstat Hydrochloridei

Grapefruit or grapefruit juice, especially if consumed in large amounts, can cause additive QT interval prolongation when taken with QT interval-prolonging drug...

Read the full interaction Moderate Likelihood Possible Red Yeast Rice + Berotralstat Hydrochloridei

Theoretically, drugs that inhibit the CYP3A4 enzymes might increase levels of lovastatin from red yeast rice.

Read the full interaction Moderate Likelihood Possible Cinchona + Berotralstat Hydrochloridei

Theoretically, taking cinchona with other QT interval-prolonging drugs might cause an additive effect and increase the risk of ventricular arrhythmias.

Read the full interaction Moderate Likelihood Possible Schisandra + Berotralstat Hydrochloridei

Schisandra might increase the levels and clinical effects of P-glycoprotein substrates.

Read the full interaction Minor Likelihood Possible Xanthan Gum + Berotralstat Hydrochloridei

Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Read the full interaction
The complete list

Every Supplement Checked Against Berotralstat Hydrochloride

All 1,452 ingredients in our database, ranked by severity — 75 with a Berotralstat Hydrochloride interaction on file and 1,377 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Berotralstat Hydrochloride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Devil's Claw with Berotralstat Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, devil's claw might increase levels of P-glycoprotein substrates.

Full Devil's Claw + Berotralstat Hydrochloride answer

Can you take Grapefruit with Berotralstat Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit or grapefruit juice, especially if consumed in large amounts, can cause additive QT interval prolongation when taken with QT inte...

Full Grapefruit + Berotralstat Hydrochloride answer

Can you take Red Yeast Rice with Berotralstat Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, drugs that inhibit the CYP3A4 enzymes might increase levels of lovastatin from red yeast rice.

Full Red Yeast Rice + Berotralstat Hydrochloride answer

Can you take Cinchona with Berotralstat Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cinchona with other QT interval-prolonging drugs might cause an additive effect and increase the risk of ventricular a...

Full Cinchona + Berotralstat Hydrochloride answer

Can you take Schisandra with Berotralstat Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Schisandra might increase the levels and clinical effects of P-glycoprotein substrates.

Full Schisandra + Berotralstat Hydrochloride answer

Can you take Activated Charcoal with Berotralstat Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Berotralstat Hydrochloride answer

Can you take Arsenic with Berotralstat Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Arsenic trioxide can prolong the QT interval.

Full Arsenic + Berotralstat Hydrochloride answer

Can you take Cesium with Berotralstat Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking cesium concomitantly with other drugs that prolong the QT interval may increase the risk of ventricular arrhythmias an...

Full Cesium + Berotralstat Hydrochloride answer

Can you take Ephedra with Berotralstat Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, ephedra might have an additive effect with drugs that prolong the QT interval.

Full Ephedra + Berotralstat Hydrochloride answer

Can you take Sida Cordifolia with Berotralstat Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, Sida cordifolia might increase the risk of additive QT interval prolongation when taken with QT interval-prolonging drugs.

Full Sida Cordifolia + Berotralstat Hydrochloride answer

Can you take St. John's Wort with Berotralstat Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Berotralstat Hydrochloride answer

Can you take American Hellebore with Berotralstat Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. American hellebore, also known as Veratrum viride, contains alkaloids that can potentially prolong the QT interval on an electrocardiogram (...

Full American Hellebore + Berotralstat Hydrochloride answer

Can you take Coffee Charcoal with Berotralstat Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Berotralstat Hydrochloride answer

Can you take European Mandrake with Berotralstat Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Berotralstat Hydrochloride answer

Can you take Glucomannan with Berotralstat Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Berotralstat Hydrochloride answer

Can you take Goldenseal with Berotralstat Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goldenseal might increase or decrease serum levels of P-glycoprotein (P-gp) substrates.

Full Goldenseal + Berotralstat Hydrochloride answer

Can you take Yohimbe with Berotralstat Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.

Full Yohimbe + Berotralstat Hydrochloride answer

Can you take Adrafinil with Berotralstat Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, drugs that inhibit CYP3A4 might increase the levels and clinical effects of adrafinil.

Full Adrafinil + Berotralstat Hydrochloride answer

Can you take Bitter Melon with Berotralstat Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter melon might increase levels of P-glycoprotein substrates.

Full Bitter Melon + Berotralstat Hydrochloride answer

Can you take Bitter Orange with Berotralstat Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the...

Full Bitter Orange + Berotralstat Hydrochloride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Berotralstat Hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Berotralstat Hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Berotralstat Hydrochloride sits in 5 interaction categories. Open any one to see what the group means:

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Berotralstat Hydrochloride through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Berotralstat Hydrochloride through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Berotralstat Hydrochloride through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Berotralstat Hydrochloride through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Berotralstat Hydrochloride through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Berotralstat Hydrochloride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Berotralstat Hydrochloride.

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Pharmacist Counseling Corner

Berotralstat Hydrochloride & Supplements: Common Questions

What supplements interact with Berotralstat Hydrochloride?
More than you might expect — 75 in total, though they are far from equal: 8 are rated major, 51 moderate, and 16 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, Arsenic, Cesium.
Which Berotralstat Hydrochloride supplement interactions are the most serious?
Focus on the major group: Activated Charcoal, Arsenic, Cesium, Ephedra and Grapefruit, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Berotralstat Hydrochloride?
Usually yes — most people on Berotralstat Hydrochloride can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Orladeyo have the same supplement interactions as Berotralstat Hydrochloride?
Yes — Orladeyo all contain Berotralstat Hydrochloride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Berotralstat Hydrochloride and my other medications?
This page covers Berotralstat Hydrochloride against supplements and herbal ingredients. Checking Berotralstat Hydrochloride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.