Medication interaction hub

What Supplements Interact with Erythromycin Ethylsuccinate?

Erythromycin Ethylsuccinate brand names: E.E.S. 400, E.E.S. Chewable, Wyamycin S. Every interaction below applies to the brands too.

202 Interactions 9 Major 153 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Erythromycin Ethylsuccinate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Erythromycin Ethylsuccinate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Most people take erythromycin ethylsuccinate (E.E.S.) for a short course to clear an infection, often with a probiotic on the side. That does not make its 202 interacting ingredients low stakes; the nine rated major deserve a careful read first. Erythromycin blocks CYP3A4, the liver enzyme that clears well over a hundred of them, so their levels can rise, while grapefruit can push erythromycin itself higher and St. John's wort can strip its effect away.

Activated charcoal also rates major, simply for soaking up the drug before it works, and the probiotics people pair with antibiotics are not dangerous, just wasted if swallowed together, so take them well apart from your dose. The remaining 153 moderate and 40 minor entries mostly follow these same patterns. What worries me most is the heart rhythm angle: erythromycin can stretch the QT interval, and 13 ingredients here, ephedra among them, add to that.

— , Clinical Pharmacist · July 18, 2026

Major 9 Moderate 153 Minor 40 No known interaction 1,250

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Erythromycin Ethylsuccinate: Top Interactions at a Glance

The Erythromycin Ethylsuccinate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 202 interacting ingredients — plus 1,250 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Erythromycin Ethylsuccinate Combinations Today

The Erythromycin Ethylsuccinate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Black Tea + Erythromycin Ethylsuccinatei

Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Read the full interaction Moderate Likelihood Possible Flaxseed + Erythromycin Ethylsuccinatei

Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.

Read the full interaction Minor Likelihood Possible Soy + Erythromycin Ethylsuccinatei

Theoretically, antibiotics may decrease the activity of soy isoflavones.

Read the full interaction Moderate Likelihood Possible Vitamin E + Erythromycin Ethylsuccinatei

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Read the full interaction Minor Likelihood Possible Ashwagandha + Erythromycin Ethylsuccinatei

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.

Read the full interaction Major Likelihood Likely Grapefruit + Erythromycin Ethylsuccinatei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Erythromycin Ethylsuccinate

All 1,452 ingredients in our database, ranked by severity — 202 with a Erythromycin Ethylsuccinate interaction on file and 1,250 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Erythromycin Ethylsuccinate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Tea with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Black Tea + Erythromycin Ethylsuccinate answer

Can you take Flaxseed with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxse...

Full Flaxseed + Erythromycin Ethylsuccinate answer

Can you take Soy with Erythromycin Ethylsuccinate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, antibiotics may decrease the activity of soy isoflavones.

Full Soy + Erythromycin Ethylsuccinate answer

Can you take Vitamin E with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Erythromycin Ethylsuccinate answer

Can you take Ashwagandha with Erythromycin Ethylsuccinate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.

Full Ashwagandha + Erythromycin Ethylsuccinate answer

Can you take Berberine with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Full Berberine + Erythromycin Ethylsuccinate answer

Can you take Beta-methylphenethylamine (bmpea) with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.

Full Beta-methylphenethylamine (bmpea) + Erythromycin Ethylsuccinate answer

Can you take Bishop's Weed with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Bishop's Weed + Erythromycin Ethylsuccinate answer

Can you take Bitter Melon with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter melon might increase levels of P-glycoprotein substrates.

Full Bitter Melon + Erythromycin Ethylsuccinate answer

Can you take Bitter Orange with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the...

Full Bitter Orange + Erythromycin Ethylsuccinate answer

Can you take Black Hellebore with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of macrolide antibiotics and black hellebore might increase risk of cardiac glycoside toxicity.

Full Black Hellebore + Erythromycin Ethylsuccinate answer

Can you take Black Pepper with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Erythromycin Ethylsuccinate answer

Can you take Bog Labrador Tea with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Erythromycin Ethylsuccinate answer

Can you take Boswellia Serrata with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Full Boswellia Serrata + Erythromycin Ethylsuccinate answer

Can you take Bulbine Natalensis with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + Erythromycin Ethylsuccinate answer

Can you take Calamus with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Erythromycin Ethylsuccinate answer

Can you take Cannabinol (cbn) with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of cannabinol.

Full Cannabinol (cbn) + Erythromycin Ethylsuccinate answer

Can you take Cannabis with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of cannabis.

Full Cannabis + Erythromycin Ethylsuccinate answer

Can you take Cat's Claw with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.

Full Cat's Claw + Erythromycin Ethylsuccinate answer

Can you take Ceylon Leadwort with Erythromycin Ethylsuccinate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Ceylon Leadwort + Erythromycin Ethylsuccinate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Erythromycin Ethylsuccinate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Erythromycin Ethylsuccinate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Erythromycin Ethylsuccinate sits in 8 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate through this category.

Macrolide Antibiotics 11 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

11 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Erythromycin Ethylsuccinate through this category.

Related: does Erythromycin Ethylsuccinate deplete any nutrients?

Erythromycin Ethylsuccinate has 21 reported nutrient associations in the research literature — see the Erythromycin Ethylsuccinate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Erythromycin Ethylsuccinate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Erythromycin Ethylsuccinate.

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Pharmacist Counseling Corner

Erythromycin Ethylsuccinate & Supplements: Common Questions

What supplements interact with Erythromycin Ethylsuccinate?
Our database currently documents 202 ingredients with a known Erythromycin Ethylsuccinate interaction (9 major, 153 moderate, 40 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 202. The highest-ranked right now: Grapefruit, Activated Charcoal, Arsenic.
Which Erythromycin Ethylsuccinate supplement interactions are the most serious?
The 9 major-rated combinations — led by Grapefruit, Activated Charcoal, Arsenic, Cesium and Ephedra — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Erythromycin Ethylsuccinate?
Plenty of supplements coexist fine with Erythromycin Ethylsuccinate; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like E.E.S. 400 have the same supplement interactions as Erythromycin Ethylsuccinate?
Yes — E.E.S. 400, E.E.S. Chewable, Wyamycin S all contain Erythromycin Ethylsuccinate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Erythromycin Ethylsuccinate deplete any vitamins or nutrients?
It might — Erythromycin Ethylsuccinate has 21 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Erythromycin Ethylsuccinate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Erythromycin Ethylsuccinate and my other medications?
This page covers Erythromycin Ethylsuccinate against supplements and herbal ingredients. Checking Erythromycin Ethylsuccinate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.