Medication interaction hub

What Supplements Interact with Erythromycin Stearate?

Erythromycin Stearate brand names: Erythro-S, Erythrocin, Ethril. Every interaction below applies to the brands too.

204 Interactions 11 Major 153 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Erythromycin Stearate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Erythromycin Stearate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Erythromycin stearate (Erythrocin, Ethril) is an antibiotic that asks for real vigilance around supplements. It blocks the body's main drug-clearing enzyme, so the largest share of this list is herbs whose blood levels can climb while you take it. It can also stretch the heart's electrical timing, and a cluster of stimulant herbs and mineral products does the same, a combination that in rare cases sets off dangerous rhythms. Grapefruit raises erythromycin's own level, while St. John's wort can lower it enough to let the infection outlast the prescription.

Everyday items show up too. Beer and wine are rated major because erythromycin raises blood alcohol, charcoal products can soak up the dose before it absorbs, and probiotics get killed along with the bacteria being treated, so space those well apart. Of the 204 ingredients on file, 153 are moderate and 40 minor, but start with the 11 rated major.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 153 Minor 40 No known interaction 1,248

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Erythromycin Stearate: Top Interactions at a Glance

The Erythromycin Stearate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 204 interacting ingredients — plus 1,248 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Erythromycin Stearate Combinations Today

The Erythromycin Stearate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Lemongrass + Erythromycin Stearatei

Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Diosmin + Erythromycin Stearatei

Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Cranberry + Erythromycin Stearatei

Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Red Yeast Rice + Erythromycin Stearatei

Theoretically, drugs that inhibit the CYP3A4 enzymes might increase levels of lovastatin from red yeast rice.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Animalis Subsp. Lactis + Erythromycin Stearatei

Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Possible Wild Cherry + Erythromycin Stearatei

In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.

Read the full interaction
The complete list

Every Supplement Checked Against Erythromycin Stearate

All 1,452 ingredients in our database, ranked by severity — 204 with a Erythromycin Stearate interaction on file and 1,248 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Erythromycin Stearate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Lemongrass with Erythromycin Stearate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.

Full Lemongrass + Erythromycin Stearate answer

Can you take Diosmin with Erythromycin Stearate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Full Diosmin + Erythromycin Stearate answer

Can you take Cranberry with Erythromycin Stearate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + Erythromycin Stearate answer

Can you take Red Yeast Rice with Erythromycin Stearate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, drugs that inhibit the CYP3A4 enzymes might increase levels of lovastatin from red yeast rice.

Full Red Yeast Rice + Erythromycin Stearate answer

Can you take Bifidobacterium Animalis Subsp. Lactis with Erythromycin Stearate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Animalis Subsp. Lactis + Erythromycin Stearate answer

Can you take Ostarine with Erythromycin Stearate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of ostarine with CYP3A4 inhibitors could increase the effects and adverse effects of ostarine, although this...

Full Ostarine + Erythromycin Stearate answer

Can you take Polypodium Leucotomos with Erythromycin Stearate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.

Full Polypodium Leucotomos + Erythromycin Stearate answer

Can you take Pomegranate with Erythromycin Stearate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to...

Full Pomegranate + Erythromycin Stearate answer

Can you take Red Clover with Erythromycin Stearate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.

Full Red Clover + Erythromycin Stearate answer

Can you take Tangerine with Erythromycin Stearate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).

Full Tangerine + Erythromycin Stearate answer

Can you take Grapefruit with Erythromycin Stearate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Erythromycin Stearate answer

Can you take Activated Charcoal with Erythromycin Stearate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Erythromycin Stearate answer

Can you take Arsenic with Erythromycin Stearate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Arsenic trioxide can prolong the QT interval.

Full Arsenic + Erythromycin Stearate answer

Can you take Beer with Erythromycin Stearate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase blood alcohol levels and adverse effects.

Full Beer + Erythromycin Stearate answer

Can you take Cesium with Erythromycin Stearate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking cesium concomitantly with other drugs that prolong the QT interval may increase the risk of ventricular arrhythmias an...

Full Cesium + Erythromycin Stearate answer

Can you take Ephedra with Erythromycin Stearate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, ephedra might have an additive effect with drugs that prolong the QT interval.

Full Ephedra + Erythromycin Stearate answer

Can you take Oleander with Erythromycin Stearate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, macrolide antibiotics may increase the risk of oleander toxicity.

Full Oleander + Erythromycin Stearate answer

Can you take Sida Cordifolia with Erythromycin Stearate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, Sida cordifolia might increase the risk of additive QT interval prolongation when taken with QT interval-prolonging drugs.

Full Sida Cordifolia + Erythromycin Stearate answer

Can you take St. John's Wort with Erythromycin Stearate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Erythromycin Stearate answer

Can you take Wine with Erythromycin Stearate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase blood alcohol levels and adverse effects.

Full Wine + Erythromycin Stearate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Erythromycin Stearate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Erythromycin Stearate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Erythromycin Stearate sits in 9 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Erythromycin Stearate through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Erythromycin Stearate through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Erythromycin Stearate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Erythromycin Stearate through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Erythromycin Stearate through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Erythromycin Stearate through this category.

Macrolide Antibiotics 11 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

11 of the supplement ingredients on this page reach Erythromycin Stearate through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Erythromycin Stearate through this category.

Erythromycin 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Erythromycin Stearate through this category.

About Erythromycin Stearate

Erythromycin is a macrolide antibiotic used to treat various bacterial infections including respiratory, skin, and sexually transmitted infections.

Generic name: Erythromycin Stearate  ·  Brand names: Erythro-S, Erythrocin, Ethril.

See the full Erythromycin drug information

Related: does Erythromycin Stearate deplete any nutrients?

Erythromycin Stearate has 21 reported nutrient associations in the research literature — see the Erythromycin Stearate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Erythromycin Stearate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Erythromycin Stearate.

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Products that contain Erythromycin Stearate-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Erythromycin Stearate.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Erythromycin Stearate & Supplements: Common Questions

What supplements interact with Erythromycin Stearate?
In our interaction database, 204 supplement and herbal ingredients have an interaction with Erythromycin Stearate on file — 11 rated major, 153 moderate, and 40 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Activated Charcoal, Arsenic.
Which Erythromycin Stearate supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal, Arsenic, Beer and Cesium, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Erythromycin Stearate?
That depends entirely on which supplement. The honest answer for Erythromycin Stearate is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Erythro-S have the same supplement interactions as Erythromycin Stearate?
Yes — Erythro-S, Erythrocin, Ethril all contain Erythromycin Stearate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Erythromycin Stearate deplete any vitamins or nutrients?
It might — Erythromycin Stearate has 21 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Erythromycin Stearate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Erythromycin Stearate and my other medications?
This page covers Erythromycin Stearate against supplements and herbal ingredients. Checking Erythromycin Stearate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Erythromycin drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.