Boldo + Erythromycin Stearate
Erythromycin Stearate brand names: Erythro-S, Erythrocin, Ethril.
We found no known interaction between Boldo and Erythromycin Stearate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Boldo and Erythromycin Stearate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Erythromycin Stearate and Boldo in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Boldo safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Erythromycin Stearate
Interactions in our licensed database are recorded against drug classes, not just single drug names. Erythromycin Stearate is filed under 9 classifications — including macrolide antibiotics, cytochrome p450 1a2 (cyp1a2) inhibitors, qt interval-prolonging drugs. Boldo has documented interactions with 5 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), hepatotoxic drugs (moderate) and lithium (moderate) — and none of Erythromycin Stearate’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Boldo Does Interact With Other Medications
Boldo has 482 moderate known drug interactions in our database — Erythromycin Stearate isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Boldo
We haven’t checked that one against Boldo yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Boldo. Pick one to open its full report.
Boldo in Pregnancy & Breastfeeding
When used orally in medicinal amounts. In animals, boldo and the constituent boldine have abortive and teratogenic effects. Also, the ascaridole constituent of boldo is a liver toxin.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Erythromycin Stearate Is Prescribed For, and What Boldo Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Erythromycin Stearate is a prescription medicine with approved uses on its FDA label. Boldo is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Erythromycin Stearate is prescribed for: Erythromycin treats bacterial infections caused by susceptible organisms. Oral and intravenous forms are used for upper and lower respiratory tract infections, skin and soft-tissue infections, pertussis (whooping cough), Legionnaires' disease, sexually transmitted infections (gonorrhea, syphilis, chlamydia), listeriosis, and other conditions. Erythrocin Lactobionate IV and erythromycin lactobionate injection are specifically for patients who cannot take oral medication or who need rapid, high blood levels due to severe infection — IV therapy should be switched to oral as soon as appropriate. Erythromycin topical solution 2% and Ery 2% Pads (swabs) are indicated only for the topical treatment of acne vulgaris (acne) and are applied directly to the skin — they are not used for internal infections.
Boldo has been studied for:
-
Gonorrhea studied, not established Boldo has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Boldo for gonorrhea
Although there has been interest in using oral boldo for gonorrhea, there is insufficient reliable information about the clinical effects of boldo for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Erythromycin Stearate on your own; if you are taking Boldo for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Boldo or Erythromycin Stearate
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Boldo or Erythromycin Stearate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Cotellic With Turmeric And Black Pepper Interaction ›
- Switching From Clindamycin To Azithromycin After Experiencing Diarrhea ›
- Is Amoxicillin Safe If You Have Atrial Fibrillation (A-Fib)? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Erythromycin Stearate
This page covers Boldo only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Erythromycin Stearate page lists 204 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Beer (major) and Cesium (major).
By severity: 11 major · 153 moderate · 40 minor.
From our pharmacist’s overview on the Erythromycin Stearate page
“Erythromycin stearate (Erythrocin, Ethril) is an antibiotic that asks for real vigilance around supplements. It blocks the body's main drug-clearing enzyme, so the largest share of this list is herbs whose blood levels can climb while you take it.”
Reviewed by 2 · Jul 18, 2026
Taking Boldo as Part of a Dietary Supplement Product? Check It for Interactions
We hold 173 real supplement products containing Boldo, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Boldo. Even though Boldo itself has no known interaction with Erythromycin Stearate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Boldo and Erythromycin Stearate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#431 of 1,452 supplements looked up here in the last 7 days
#2,101 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Boldo reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Boldo and Erythromycin Stearate records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Boldo
What is Boldo?
- Indigestion and bloating
- Mild constipation
- Liver and gallbladder support
- Appetite stimulation
- Urinary complaints
Boldo is a South American shrub whose leaves are traditionally used for digestive and gallbladder complaints, but good human evidence is very limited. The leaves and oil contain ascaridole, which can be toxic to the liver, so only ascaridole-free products should be used and only for short periods. Talk to your pharmacist or doctor before trying it, and avoid it during pregnancy and breastfeeding.
Peumus boldus · Monimiaceae · Leaves and essential oil · Tea, dried leaf, tincture, capsules, essential oil
An interaction check asks whether these two react with each other — it does not ask whether Boldo is a good idea for someone in your situation. Here is what our Boldo record says about it on its own.
Boldo: dosing
There is no well-established standardized dose for boldo, and products vary widely in strength and in how much ascaridole they contain. Because of this, it is best to follow the directions on the product label and use it only for short periods.Choose products labeled as ascaridole-free when possible, and avoid the pure essential oil.
From our Boldo monograph — the full record covers uses, side effects and every documented interaction.
About Erythromycin
What Is Erythromycin Used For?
Brand names: Erythro-S, Erythrocin, Ethril
Erythromycin treats bacterial infections caused by susceptible organisms. Oral and intravenous forms are used for upper and lower respiratory tract infections, skin and soft-tissue infections, pertussis (whooping cough), Legionnaires' disease, sexually transmitted infections (gonorrhea, syphilis, chlamydia), listeriosis, and other conditions. Erythrocin Lactobionate IV and erythromycin lactobionate injection are specifically for patients who cannot take oral medication or who need rapid, high blood levels due to severe infection — IV therapy should be switched to oral as soon as appropriate.
Erythromycin topical solution 2% and Ery 2% Pads (swabs) are indicated only for the topical treatment of acne vulgaris (acne) and are applied directly to the skin — they are not used for internal infections.
Other Drugs & Boldo
Browse every other medication we’ve checked against Boldo — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
482 interactions
- Diclofenac Sodium ›
- Nifedipine ›
- Ibuprofen ›
- Aspirin ›
- Naproxen ›
- Doxycycline ›
- Minocycline ›
- Tetracycline ›
- Amoxicillin ›
- Testosterone ›
- Verapamil ›
- Fenofibrate ›
- Levonorgestrel ›
- Quinidine ›
- Cyclosporine ›
- Glyburide ›
- Methyltestosterone ›
- Ciprofloxacin ›
- Phenytoin ›
- Tacrolimus ›
- Allopurinol ›
- Carbamazepine ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Acetaminophen ›
- Ketoprofen ›
- Methotrexate ›
- Nitrofurantoin ›
- Ofloxacin ›
- Propoxyphene ›
- Rifampin ›
- Testosterone Undecanoate ›
- Acarbose ›
- Bivalirudin ›
- Dapsone ›
- Doxycycline Hyclate ›
- Duloxetine ›
- Eltrombopag ›
- Interferon Alfa-2b ›
- Interferon Beta-1b ›
- Isoniazid ›
- Itraconazole ›
- Levofloxacin ›
- Naltrexone ›
- Riluzole ›
- Valproic Acid ›
- Warfarin Sodium ›
- Abiraterone Acetate ›
- Acebutolol ›
- Ambrisentan ›
- Amiodarone ›
- Azathioprine ›
- Bromfenac Sodium ›
- Chlorpropamide ›
- Choline Magnesium Trisalicylate ›
- Cyclophosphamide ›
- Dabigatran ›
- Daclizumab ›
- Dantrolene ›
- Deferasirox ›
Showing 60 of 482 moderate interactions — see all 482 on the Boldo page.
No interaction 2,347 drugs checked — show the list
We also checked Boldo against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Metoprolol ›
- Escitalopram ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Methamphetamine ›
- Hydroxyurea ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Citalopram ›
- Buspirone ›
- Bisoprolol ›
- Candesartan Cilexetil ›
- Diazepam ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Cyclopentolate ›
- Cephalexin ›
- Mannitol ›
- Roxithromycin ›
- Levetiracetam ›
- Ezetimibe ›
- Spironolactone ›
- Phentermine, Topiramate ›
- Amlodipine Besylate, Benazepril ›
- Mirtazapine ›
- Dexmethylphenidate ›
- Levothyroxine Sodium ›
- Finasteride ›
Showing the 60 most looked-up of 2,347 medications checked with no known interaction — see the full Boldo list.
Boldo References
The 10 references that drive our Boldo monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
- Piscaglia F, Leoni S, Venturi A, et al. Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity. Scand J Gastroenterol 2005;40:236-9. PubMed
- Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
- Teng, C. M., Hsueh, C. M., Chang, Y. L., Ko, F. N., Lee, S. S., and Liu, K. C. Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. J Pharm Pharmacol 1997;49(7):706-711. PubMed
- Carbajal R, Yisfalem A, Pradhan N, et al. Case report: Boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. Transplant Proc 2014;46(7):2400-2. PubMed
- Almeida ER, Melo AM, Xavier H. Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytother Res 2000;14(2):99-102. DOI
- Ribeiro RJ, Silvestre C, Duarte C. Hidden risks of alternative medicines: a case of boldo-induced hepatotoxicity. J Diet Suppl 2017;14(2):186-90. PubMed
- Oliveira Sá A, Pimentel T, Oliveira N. Boldo-Induced Hepatotoxicity: A Case of Unexplained Jaundice. Eur J Case Rep Intern Med 2020;7(12):002116. PubMed
- Valdes R, Feuereisen A, Bellinghausen M. Allergic Contact Dermatitis to Boldo. Dermatitis 2021;32(2):e31-e32. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Erythromycin Stearate Is Linked to Lower Levels of 7 Nutrients
Natural Medicines records Erythromycin Stearate as a medicine that can lower these. This is not an interaction with Boldo — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Erythromycin Stearate nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Boldo and Erythromycin Stearate Together: Common Questions
Is it safe to take Boldo with Erythromycin Stearate?
Do Boldo and Erythromycin Stearate have any of the same side effects?
Are Boldo and Erythromycin Stearate used for the same thing?
How was the Boldo and Erythromycin Stearate combination checked?
Does Boldo interact with any other medications?
Does Erythromycin Stearate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.