Drug & supplement interaction

Irvingia Gabonensis + Berotralstat Hydrochloride

Berotralstat Hydrochloride brand name: Orladeyo.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Irvingia Gabonensis and Berotralstat Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Berotralstat Hydrochloride states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Irvingia Gabonensis and Berotralstat Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Berotralstat Hydrochloride and Irvingia Gabonensis in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Irvingia Gabonensis safety at a glance

Irvingia Gabonensi... overall Use caution Generally tolerated short-term in studies, but long-term safety and product quality are not well established.
Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety information is available while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Berotralstat Hydrochloride and Irvingia Gabonensis? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Berotralstat Hydrochloride

Interactions in our licensed database are recorded against drug classes, not just single drug names. Berotralstat Hydrochloride is filed under 5 classifications — including cytochrome p450 2d6 (cyp2d6) inhibitors, qt interval-prolonging drugs, cytochrome p450 3a4 (cyp3a4) inhibitors. Irvingia Gabonensis has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and testosterone (moderate) — and none of Berotralstat Hydrochloride’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Irvingia Gabonensis Does Interact With Other Medications

Irvingia Gabonensis has 94 moderate known drug interactions in our database — Berotralstat Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.

Moderate 94 No known interaction 2,736 (incl. Berotralstat Hydrochloride)
Taking anything else?

Check Another of Your Medications Against Irvingia Gabonensis

Covers the 2,830 medications we’ve checked against Irvingia Gabonensis. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Irvingia Gabonensis and Berotralstat Hydrochloride May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach upset Additional detail

    Irvingia Gabonensis

    “One case of acute hepatitis secondary to Irvingia gabonensis has been reported. A 45-year old male with a ten-day history of Irvingia gabonensis supplementation, at a dose of 350 mg of seed extract twice daily for body fat reduction, was admitted with jaundice, abdominal discomfort, and new onset malaise. His complaints began four days after starting Irvingia gabonensis supplementation.”

    Irvingia Gabonensis · Natural Medicines adverse-effect record, reported in alcohol-related liver disease.

    1 source cited
    1. 92824. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.

    Berotralstat Hydrochloride

    Listed in the ADVERSE REACTIONS section of the FDA label for Berotralstat Hydrochloride. Read the label on DailyMed ›

Reported for Irvingia Gabonensis but not commonly for Berotralstat Hydrochloride: bloating or gas, liver problems, headache and trouble sleeping.

Effects for Berotralstat Hydrochloride come from the ADVERSE REACTIONS section of its FDA label; effects for Irvingia Gabonensis come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Berotralstat Hydrochloride Products Have a Food Rule — Irvingia Gabonensis Should Not Break It

At least one FDA label for a product containing Berotralstat Hydrochloride says to take it with food. If you take Irvingia Gabonensis on an empty stomach out of habit, keep them separate — and take Berotralstat Hydrochloride with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Berotralstat Hydrochloride products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Recommended dosage in adult and pediatric patients aged 12 years and older: 150 mg capsule orally once daily with food.

From the Dosage and Administration section of the FDA label we read for Berotralstat Hydrochloride — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Berotralstat Hydrochloride

This page covers Irvingia Gabonensis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Berotralstat Hydrochloride page lists 75 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 51 moderate · 16 minor.

From our pharmacist’s overview on the Berotralstat Hydrochloride page

“If you take berotralstat (Orladeyo) to prevent hereditary angioedema attacks, this list deserves real attention, and the eight major-rated entries are where to start. The biggest cluster, 37 ingredients, affects the gut pump that moves berotralstat into your body; St.”

Reviewed by 2 · Jul 18, 2026

Open the Berotralstat Hydrochloride interaction page

One more smart check

Taking Irvingia Gabonensis as Part of a Dietary Supplement Product? Check It for Interactions

We hold 406 real supplement products containing Irvingia Gabonensis, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Irvingia Gabonensis. Even though Irvingia Gabonensis itself has no known interaction with Berotralstat Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Irvingia Gabonensis and Berotralstat Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Irvingia Gabonensis
Top 25%

#304 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Berotralstat Hydrochloride
Top half

#1,119 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Irvingia Gabonensis reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Irvingia Gabonensis and Berotralstat Hydrochloride records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Irvingia Gabonensis

What is Irvingia Gabonensis?

Irvingia Gabonensis
  • Weight loss
  • Appetite control
  • Cholesterol support
  • Blood sugar support
  • Metabolism support

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low-quality, so the true effect is uncertain. Talk with your pharmacist or doctor before using it, and do not rely on it in place of proven diet and lifestyle changes.

Irvingia gabonensis · Irvingiaceae · Seed (kernel, also called dika nut); seed extract · Capsules, tablets, powder, standardized seed extract

An interaction check asks whether these two react with each other — it does not ask whether Irvingia Gabonensis is a good idea for someone in your situation. Here is what our Irvingia Gabonensis record says about it on its own.

Irvingia Gabonensis: dosing

There is no officially established or standardized dose for Irvingia gabonensis. Studies have used different seed extracts and amounts, so it is hard to recommend one specific dose.If you choose to try it, follow the directions on the product label and do not exceed them.

From our Irvingia Gabonensis monograph — the full record covers uses, side effects and every documented interaction.

Read the full Irvingia Gabonensis monograph & all interactions
Keep checking

Other Drugs & Irvingia Gabonensis

Browse every other medication we’ve checked against Irvingia Gabonensis — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
94Moderate
0Minor
2,735No known interaction
94 Moderate 2,735 No interaction
Moderate

94 interactions

Showing 60 of 94 moderate interactions — see all 94 on the Irvingia Gabonensis page.

No interaction 2,735 drugs checked — show the list

We also checked Irvingia Gabonensis against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,735 medications checked with no known interaction — see the full Irvingia Gabonensis list.

See the full Irvingia Gabonensis interactions page
See every supplement checked against Berotralstat Hydrochloride, ranked by severity
Evidence & sources

Irvingia Gabonensis References

The 7 references that drive our Irvingia Gabonensis monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Irvingia Gabonensis and Berotralstat Hydrochloride Together: Common Questions

Is it safe to take Irvingia Gabonensis with Berotralstat Hydrochloride?
We do not list a known interaction between Irvingia Gabonensis and Berotralstat Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Irvingia Gabonensis and Berotralstat Hydrochloride have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Irvingia Gabonensis and Berotralstat Hydrochloride at the same time of day?
At least one FDA label for a product containing Berotralstat Hydrochloride says to take it with food. If you take Irvingia Gabonensis on an empty stomach out of habit, keep them separate and take Berotralstat Hydrochloride with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Berotralstat Hydrochloride products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Irvingia Gabonensis and Berotralstat Hydrochloride combination checked?
Interactions in our licensed database are recorded against drug classes. Berotralstat Hydrochloride is filed under 5 classifications, and Irvingia Gabonensis has documented interactions with 2 drug classes — none of Berotralstat Hydrochloride's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Irvingia Gabonensis interact with any other medications?
Yes. Irvingia Gabonensis has 94 documented drug interactions in our database — Berotralstat Hydrochloride is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Berotralstat Hydrochloride interact with any supplements?
Yes. Berotralstat Hydrochloride has documented interactions with 75 supplements in our database — Irvingia Gabonensis is not one of them. The Berotralstat Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Irvingia Gabonensis monograph Uses, safety profile, and every drug interaction in one place Berotralstat Hydrochloride supplement interactions Every supplement checked against Berotralstat Hydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.