Drug & supplement interaction

Betony + Berotralstat Hydrochloride

Berotralstat Hydrochloride brand name: Orladeyo.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Betony and Berotralstat Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Berotralstat Hydrochloride states a food rule worth keeping to.

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Interaction report

Betony and Berotralstat Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Berotralstat Hydrochloride and Betony in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Betony safety at a glance

Betony overall Use caution Generally used in traditional teas, but human safety data are limited, so use with care.
Pregnancy Avoid Traditionally avoided in pregnancy because of possible effects on the uterus; safety is not established.
Breastfeeding Avoid There is not enough safety information, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Berotralstat Hydrochloride and Betony? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Berotralstat Hydrochloride

Interactions in our licensed database are recorded against drug classes, not just single drug names. Berotralstat Hydrochloride is filed under 5 classifications — including cytochrome p450 2d6 (cyp2d6) inhibitors, qt interval-prolonging drugs, cytochrome p450 3a4 (cyp3a4) inhibitors. Betony has documented interactions with 1 drug class — the most serious being antihypertensive drugs (moderate) — and none of Berotralstat Hydrochloride’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Betony Does Interact With Other Medications

Betony has 172 moderate known drug interactions in our database — Berotralstat Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Berotralstat Hydrochloride)
Taking anything else?

Check Another of Your Medications Against Betony

Covers the 2,830 medications we’ve checked against Betony. Pick one to open its full report.

What to actually watch for

What Berotralstat Hydrochloride’s Own FDA Label Lists

This is not an interaction — none of it involves Betony. These are the most notable effects listed in the ADVERSE REACTIONS section of Berotralstat Hydrochloride’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both.

  • Heartburn
  • Back pain
  • Stomach upset
  • Stomach pain
  • Diarrhea
  • Vomiting

From the ADVERSE REACTIONS section of the FDA label for Berotralstat Hydrochloride. Read the label on DailyMed › Betony’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Betony side to compare — that is a limit of the record, not a statement that Betony has no side effects.

How to take them

Some Berotralstat Hydrochloride Products Have a Food Rule — Betony Should Not Break It

At least one FDA label for a product containing Berotralstat Hydrochloride says to take it with food. If you take Betony on an empty stomach out of habit, keep them separate — and take Berotralstat Hydrochloride with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Berotralstat Hydrochloride products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Recommended dosage in adult and pediatric patients aged 12 years and older: 150 mg capsule orally once daily with food.

From the Dosage and Administration section of the FDA label we read for Berotralstat Hydrochloride — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Berotralstat Hydrochloride

This page covers Betony only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Berotralstat Hydrochloride page lists 75 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 51 moderate · 16 minor.

From our pharmacist’s overview on the Berotralstat Hydrochloride page

“If you take berotralstat (Orladeyo) to prevent hereditary angioedema attacks, this list deserves real attention, and the eight major-rated entries are where to start. The biggest cluster, 37 ingredients, affects the gut pump that moves berotralstat into your body; St.”

Reviewed by 2 · Jul 18, 2026

Open the Berotralstat Hydrochloride interaction page

One more smart check

Taking Betony as Part of a Dietary Supplement Product? Check It for Interactions

We hold 188 real supplement products containing Betony, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Betony. Even though Betony itself has no known interaction with Berotralstat Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Betony and Berotralstat Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Betony
Top half

#436 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Berotralstat Hydrochloride
Top 25%

#673 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Betony reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Betony and Berotralstat Hydrochloride records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Betony

What is Betony?

  • Headaches and tension
  • Anxiety and nervous tension
  • Digestive upset
  • Sore throat and mouth rinse
  • Mild diarrhea

Betony (Stachys officinalis) is a traditional European herb long used for headaches, nervous tension, and digestive complaints. Modern scientific evidence supporting these uses is very limited, and most claims rest on tradition rather than well-designed human studies. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Stachys officinalis · Lamiaceae · Aerial parts (leaves, stems, and flowers) · Tea, tincture, dried herb, capsules

An interaction check asks whether these two react with each other — it does not ask whether Betony is a good idea for someone in your situation. Here is what our Betony record says about it on its own.

Betony: dosing

There is no standardized or officially established dose for betony. Traditional use typically involved a tea made from a small amount of the dried herb, but reliable dosing information from clinical studies is not available.If you decide to use a betony product, follow the directions on the product label and do not exceed the recommended amount.

From our Betony monograph — the full record covers uses, side effects and every documented interaction.

Read the full Betony monograph & all interactions
Keep checking

Other Drugs & Betony

Browse every other medication we’ve checked against Betony — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
0Minor
2,657No known interaction
172 Moderate 2,657 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Betony page.

No interaction 2,657 drugs checked — show the list

We also checked Betony against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Betony list.

See the full Betony interactions page
See every supplement checked against Berotralstat Hydrochloride, ranked by severity
Evidence & sources

Betony References

The 2 references that drive our Betony monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Betony and Berotralstat Hydrochloride Together: Common Questions

Is it safe to take Betony with Berotralstat Hydrochloride?
We do not list a known interaction between Betony and Berotralstat Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Betony and Berotralstat Hydrochloride at the same time of day?
At least one FDA label for a product containing Berotralstat Hydrochloride says to take it with food. If you take Betony on an empty stomach out of habit, keep them separate and take Berotralstat Hydrochloride with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Berotralstat Hydrochloride products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Betony and Berotralstat Hydrochloride combination checked?
Interactions in our licensed database are recorded against drug classes. Berotralstat Hydrochloride is filed under 5 classifications, and Betony has documented interactions with 1 drug class — none of Berotralstat Hydrochloride's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Betony interact with any other medications?
Yes. Betony has 172 documented drug interactions in our database — Berotralstat Hydrochloride is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Berotralstat Hydrochloride interact with any supplements?
Yes. Berotralstat Hydrochloride has documented interactions with 75 supplements in our database — Betony is not one of them. The Berotralstat Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Betony monograph Uses, safety profile, and every drug interaction in one place Berotralstat Hydrochloride supplement interactions Every supplement checked against Berotralstat Hydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Berotralstat Hydrochloride and Betony?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.