Medication interaction hub

What Supplements Interact with Chloramphenicol?

Chloramphenicol brand names: Chloromycetin, Chloromycetin Ophthalmic, Chloromycetin Injection. Every interaction below applies to the brands too.

32 Interactions 30 Moderate 2 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Chloramphenicol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Chloramphenicol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Almost everything on this chloramphenicol list points at the supplement rather than the drug. Chloramphenicol is a powerful antibiotic, usually reserved for serious infections or used as eye drops, and the great majority of entries are probiotics and fermented products such as acidophilus and Bifidobacterium strains. The antibiotic can kill those live organisms, so a probiotic swallowed alongside a dose may simply not work. For most people this is a watch-and-manage list, not a reason to stay away from either product.

Spacing doses well apart, rather than taking both at once, handles the probiotic group. Four remaining ingredients act on a liver enzyme called CYP2C9, which can shift medication levels, and those are the ones to flag for your pharmacist. Of the 32 ingredients on file, none rates major; 30 are moderate and two minor, which fits a list mostly about protecting effectiveness rather than preventing harm.

— , Clinical Pharmacist · July 18, 2026

Moderate 30 Minor 2 No known interaction 1,420

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Chloramphenicol: Top Interactions at a Glance

The Chloramphenicol supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 32 interacting ingredients — plus 1,420 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Chloramphenicol Combinations Today

The Chloramphenicol + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Iron + Chloramphenicoli

Theoretically, taking chloramphenicol with iron might reduce the response to iron therapy in iron deficiency anemia.

Read the full interaction Moderate Likelihood Possible Flaxseed + Chloramphenicoli

Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.

Read the full interaction Moderate Likelihood Probable Ligilactobacillus Salivarius + Chloramphenicoli

Theoretically, taking Ligilactobacillus salivarius with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction Moderate Likelihood Probable Lacticaseibacillus Paracasei + Chloramphenicoli

Theoretically, taking Lacticaseibacillus paracasei with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction Moderate Likelihood Probable Bacillus Coagulans + Chloramphenicoli

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Bacillus Subtilis + Chloramphenicoli

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction
The complete list

Every Supplement Checked Against Chloramphenicol

All 1,452 ingredients in our database, ranked by severity — 32 with a Chloramphenicol interaction on file and 1,420 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Chloramphenicol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Iron with Chloramphenicol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking chloramphenicol with iron might reduce the response to iron therapy in iron deficiency anemia.

Full Iron + Chloramphenicol answer

Can you take Flaxseed with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxse...

Full Flaxseed + Chloramphenicol answer

Can you take Ligilactobacillus Salivarius with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Ligilactobacillus salivarius with antibiotic drugs might decrease the effectiveness of L.

Full Ligilactobacillus Salivarius + Chloramphenicol answer

Can you take Lacticaseibacillus Paracasei with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus paracasei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Paracasei + Chloramphenicol answer

Can you take Cannabis with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, drugs that are CYP2C9 inhibitors might increase the adverse effects of cannabis.

Full Cannabis + Chloramphenicol answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, drugs that are CYP2C9 inhibitors might increase the levels and adverse effects of THC.

Full Delta-9-tetrahydrocannabinol (thc) + Chloramphenicol answer

Can you take Limonene with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C9 (CYP2C9).

Full Limonene + Chloramphenicol answer

Can you take Soy with Chloramphenicol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, antibiotics may decrease the activity of soy isoflavones.

Full Soy + Chloramphenicol answer

Can you take Bacillus Coagulans with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Full Bacillus Coagulans + Chloramphenicol answer

Can you take Bacillus Subtilis with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.

Full Bacillus Subtilis + Chloramphenicol answer

Can you take Bifidobacterium Animalis Subsp. Lactis with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Animalis Subsp. Lactis + Chloramphenicol answer

Can you take Bifidobacterium Bifidum with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium.

Full Bifidobacterium Bifidum + Chloramphenicol answer

Can you take Bifidobacterium Breve with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Breve + Chloramphenicol answer

Can you take Bifidobacterium Longum with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Longum + Chloramphenicol answer

Can you take Fermented Milk with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotic drugs might decrease the effectiveness of fermented milk.

Full Fermented Milk + Chloramphenicol answer

Can you take Lacticaseibacillus Casei with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus casei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Casei + Chloramphenicol answer

Can you take Lacticaseibacillus Rhamnosus with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus rhamnosus with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Rhamnosus + Chloramphenicol answer

Can you take Lactiplantibacillus Pentosus with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactiplantibacillus pentosus with antibiotic drugs might decrease the effectiveness of L.

Full Lactiplantibacillus Pentosus + Chloramphenicol answer

Can you take Lactiplantibacillus Plantarum with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Full Lactiplantibacillus Plantarum + Chloramphenicol answer

Can you take Lactobacillus Acidophilus with Chloramphenicol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Acidophilus + Chloramphenicol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Chloramphenicol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Chloramphenicol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Chloramphenicol sits in 3 interaction categories. Open any one to see what the group means:

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Chloramphenicol through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Chloramphenicol through this category.

Chloramphenicol 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Chloramphenicol through this category.

About Chloramphenicol

Chloramphenicol Injection is a broad-spectrum antibiotic used intravenously for serious bacterial infections when safer alternatives are not effective.

Generic name: Chloramphenicol  ·  Brand names: Chloromycetin, Chloromycetin Ophthalmic, Chloromycetin Injection.

See the full Chloramphenicol Injection drug information

Related: does Chloramphenicol deplete any nutrients?

Chloramphenicol has 8 reported nutrient associations in the research literature — see the Chloramphenicol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Chloramphenicol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Chloramphenicol.

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Pharmacist Counseling Corner

Chloramphenicol & Supplements: Common Questions

What supplements interact with Chloramphenicol?
In our interaction database, 32 supplement and herbal ingredients have an interaction with Chloramphenicol on file — 0 rated major, 30 moderate, and 2 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Bacillus Coagulans, Bacillus Subtilis, Bifidobacterium Animalis Subsp. Lactis.
Which Chloramphenicol supplement interactions are the most serious?
None of the Chloramphenicol supplement interactions on file are currently rated major. The most significant are the 30 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on Chloramphenicol?
That depends entirely on which supplement. The honest answer for Chloramphenicol is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Chloromycetin have the same supplement interactions as Chloramphenicol?
Yes — Chloromycetin, Chloromycetin Ophthalmic, Chloromycetin Injection all contain Chloramphenicol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Chloramphenicol deplete any vitamins or nutrients?
It might — Chloramphenicol has 8 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Chloramphenicol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Chloramphenicol and my other medications?
This page covers Chloramphenicol against supplements and herbal ingredients. Checking Chloramphenicol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Chloramphenicol Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.