Drug & supplement interaction

D-mannose + Chloramphenicol

Chloramphenicol brand names: Chloromycetin, Chloromycetin Ophthalmic, Chloromycetin Injection.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between D-mannose and Chloramphenicol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

D-mannose and Chloramphenicol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Chloramphenicol and D-mannose in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for D-mannose at all — not against Chloramphenicol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

D-mannose safety at a glance

D-mannose overall Use caution Generally well tolerated short-term, but high-quality long-term safety data are limited.
Pregnancy Use caution Not enough reliable safety data, so it is best to avoid unless your doctor advises otherwise.
Breastfeeding Use caution Safety while breastfeeding is not well studied, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Chloramphenicol and D-mannose? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests D-mannose and Chloramphenicol May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Bloating or gas / Diarrhea / Nausea Additional detail

    D-mannose

    “Orally, D-mannose can cause loose stools, diarrhea, abdominal bloating, and nausea. In children, loose stools and abdominal bloating have been reported at D-mannose doses ranging from 100 mg/kg three times daily to 150 mg/kg five times daily. Diarrhea has been reported in adults taking D-mannose 2 grams daily for 6 months.”

    D-mannose · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 13344. Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
    2. 91141. Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
    3. 100979. Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
    4. 100981. . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
    5. 104209. Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
    6. 100977. de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed

    Chloramphenicol

    Listed in the ADVERSE REACTIONS section of the FDA label for Chloramphenicol. Read the label on DailyMed ›

Effects for Chloramphenicol come from the ADVERSE REACTIONS section of its FDA label; effects for D-mannose come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 28 voluntary FDA FAERS reports for Chloramphenicol that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Chloramphenicol

This page covers D-mannose only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chloramphenicol page lists 32 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Bacillus Coagulans (moderate), Bacillus Subtilis (moderate), Bifidobacterium Animalis Subsp. Lactis (moderate), Bifidobacterium Bifidum (moderate) and Bifidobacterium Breve (moderate).

By severity: 30 moderate · 2 minor.

From our pharmacist’s overview on the Chloramphenicol page

“Almost everything on this chloramphenicol list points at the supplement rather than the drug. Chloramphenicol is a powerful antibiotic, usually reserved for serious infections or used as eye drops, and the great majority of entries are probiotics and fermented products such as acidophilus and Bifidobacterium strains.”

Reviewed by 2 · Jul 18, 2026

Open the Chloramphenicol interaction page

How much people look this up

Where D-mannose and Chloramphenicol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement D-mannose
Steady interest

#749 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Chloramphenicol
Top half

#1,373 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every D-mannose reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The D-mannose and Chloramphenicol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About D-mannose

What is D-mannose?

D-mannose
  • Preventing urinary tract infections (UTIs)
  • Treating mild UTIs
  • Urinary tract health
  • Carbohydrate-deficient glycoprotein syndrome (a rare genetic condition)

D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising for prevention, but the evidence is still limited and it should not replace antibiotics for an active infection. Talk to your pharmacist or doctor before using it, particularly if you are pregnant, breastfeeding, or have diabetes.

Simple sugar (monosaccharide) derived from plants such as cranberries, apples, and other fruits and vegetables · Capsules, tablets, powder; often combined with cranberry

An interaction check asks whether these two react with each other — it does not ask whether D-mannose is a good idea for someone in your situation. Here is what our D-mannose record says about it on its own.

D-mannose: dosing

There is no official, standardized dose of D-mannose, and the amounts used in research have varied. Do not use D-mannose in place of prescribed antibiotics for an active infection.

From our D-mannose monograph — the full record covers uses, side effects and every documented interaction.

Read the full D-mannose monograph & all interactions
Medication

About Chloramphenicol Injection

What Is Chloramphenicol Injection Used For?

Brand names: Chloromycetin, Chloromycetin Ophthalmic, Chloromycetin Injection

Chloramphenicol Sodium Succinate Injection is used intravenously to treat serious infections caused by susceptible bacteria. It is active against organisms including Haemophilus influenzae, Salmonella species (including Salmonella typhi, the cause of typhoid fever), Rickettsia, and the lymphogranuloma-psittacosis group.

Because of its serious risks, this medication is reserved for infections where less dangerous antibiotics will not work. It must not be used for minor infections such as colds, flu, or sore throats, or to prevent infections.

Most-Reported Side Effects for Chloramphenicol

From FAERS, the FDA’s public side-effect reporting system (28 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Grey syndrome neonatal 4 reports
Headache 3 reports
Lethargy 3 reports
Metabolic acidosis 3 reports
Alanine aminotransferase increased 2 reports
See full Chloramphenicol Injection drug information
Keep checking

Other Drugs & D-mannose

Browse every other medication we’ve checked against D-mannose — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked D-mannose against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full D-mannose list.

See the full D-mannose interactions page
See every supplement checked against Chloramphenicol, ranked by severity
Evidence & sources

D-mannose References

The 6 references that drive our D-mannose monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
  2. Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
  3. de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
  4. Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
  5. . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
  6. Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking D-mannose and Chloramphenicol Together: Common Questions

Is it safe to take D-mannose with Chloramphenicol?
We do not list a known interaction between D-mannose and Chloramphenicol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do D-mannose and Chloramphenicol have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Chloramphenicol interact with any supplements?
Yes. Chloramphenicol has documented interactions with 32 supplements in our database — D-mannose is not one of them. The Chloramphenicol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

D-mannose monograph Uses, safety profile, and every drug interaction in one place Chloramphenicol Injection drug information The full plain-English guide to this medication Chloramphenicol supplement interactions Every supplement checked against Chloramphenicol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Chloramphenicol and D-mannose?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.