Chloramphenicol Injection

30 interactions 316 cited references
Also sold as: Chloromycetin® Injection Mychel-S® Injection Viceton
About Chloramphenicol Injection

Chloramphenicol injection is used to treat certain types of serious infections caused by bacteria when other antibiotics cannot be used. Chloramphenicol injection is in a class of medications called antibiotics. It works by stopping the growth of bacteria.. Antibiotics such as chloramphenicol injection will not work fo… Read the full Chloramphenicol Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Cholera Vaccine, Live Exenatide Fosphenytoin Methotrexate Phenytoin Rifampin
8 Major 17 Moderate 5 Minor
All (30) Major (8) Moderate (17) Minor (5)

Major

Chloramphenicol Injection Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Chloramphenicol Injection Exenatide Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Chloramphenicol Injection Fosphenytoin Cerebyx Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Chloramphenicol Injection Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Chloramphenicol Injection Phenytoin Dilantin Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Chloramphenicol Injection Rifampin Rifadin Reduced chloramphenicol exposure Details Chloramphenicol Injection Tacrolimus Astagraf Increased tacrolimus exposure and an increased risk of tacrolimus toxicity Details Chloramphenicol Injection Voriconazole Vfend Increased voriconazole exposure and plasma concentrations Details

Moderate

Chloramphenicol Injection Ceftazidime Decreased ceftazidime effectiveness Details Chloramphenicol Injection Chlorpropamide Diabinese® Hypoglycemia (CNS depression, seizures) Details Chloramphenicol Injection Clopidogrel Plavix Reduction in clinical efficacy of clopidogrel Details Chloramphenicol Injection Cyanocobalamin Dodex Decreased efficacy of cyanocobalamin when used to treat anemia Details Chloramphenicol Injection Cyclophosphamide Cytoxan® Decreased cyclophosphamide effectiveness Details Chloramphenicol Injection Cyclosporine Atopica An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Chloramphenicol Injection Dicumarol Increased risk of bleeding Details Chloramphenicol Injection Entacapone Comtan An increased risk of enhanced entacapone adverse effects (diarrhea, dyskinesias) Details Chloramphenicol Injection Glimepiride Amaryl Hypoglycemia Details Chloramphenicol Injection Glyburide DiaBeta® Excessive hypoglycemia Details Chloramphenicol Injection Lixisenatide Delayed therapeutic effect Details Chloramphenicol Injection Phenobarbital Fidoquel Phenobarbital toxicity or decreased chloramphenicol effectiveness Details Chloramphenicol Injection Rifapentine Priftin Decreased chloramphenicol effectiveness Details Chloramphenicol Injection Tetanus Toxoid Inhibition of the immunologic response to the tetanus toxoid Details Chloramphenicol Injection Tolbutamide Orinase® Hypoglycemia (CNS depression, seizures) Details Chloramphenicol Injection Typhoid Vaccine, Live Vivotif A decreased immunological response to the typhoid vaccine Details Chloramphenicol Injection Warfarin Coumadin An increased risk of bleeding Details

Minor

Chloramphenicol Injection Acetaminophen Acephen Chloramphenicol toxicity (vomiting, hypotension, hypothermia) Details Chloramphenicol Injection Iron Decreased iron effectiveness Details Chloramphenicol Injection Penicillin G Decreased antibacterial effectiveness Details Chloramphenicol Injection Penicillin G Procaine Decreased antibacterial effectiveness Details Chloramphenicol Injection Penicillin V Decreased antibacterial effectiveness Details

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