Chloramphenicol Injection

Name: Chloramphenicol Injection Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

30 interactions 316 cited references

Also sold as: Chloromycetin® Injection Mychel-S® Injection Viceton

About Chloramphenicol Injection

Chloramphenicol injection is used to treat certain types of serious infections caused by bacteria when other antibiotics cannot be used. Chloramphenicol injection is in a class of medications called antibiotics. It works by stopping the growth of bacteria.. Antibiotics such as chloramphenicol injection will not work fo… Read the full Chloramphenicol Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Cholera Vaccine, Live Exenatide Fosphenytoin Methotrexate Phenytoin Rifampin

8 Major 17 Moderate 5 Minor

All (30) Major (8) Moderate (17) Minor (5)

Major

Chloramphenicol Injection Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Chloramphenicol Injection Exenatide Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Chloramphenicol Injection Fosphenytoin Cerebyx Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Chloramphenicol Injection Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Chloramphenicol Injection Phenytoin Dilantin Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Chloramphenicol Injection Rifampin Rifadin Reduced chloramphenicol exposure Details Chloramphenicol Injection Tacrolimus Astagraf Increased tacrolimus exposure and an increased risk of tacrolimus toxicity Details Chloramphenicol Injection Voriconazole Vfend Increased voriconazole exposure and plasma concentrations Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.