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Ceftazidime and Avibactam Injection

Ceftazidime and avibactam injection is a combination antibiotic used to treat serious bacterial infections including complicated intra-abdominal infections, complicated urinary tract infections, and hospital-acquired or ventilator-associated bacterial pneumonia.

Brand name Avycaz
Drug classes Cephalosporin Antibacterial
Rx Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 1 clinical label set within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 5, 2026
Ceftazidime and Avibactam Injection at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Avycaz is a hospital IV antibiotic, on the market since about 2014, that pairs ceftazidime (a cephalosporin that stops bacteria from building their cell walls) with avibactam (which blocks the enzymes resistant bacteria use to destroy ceftazidime), and it is a reserve drug saved for serious, hard-to-treat infections of the abdomen, urinary tract or lungs. Most people tolerate it reasonably well, and diarrhea, nausea and headache are the usual complaints. Watch for diarrhea that turns severe, watery or bloody, even months later, since that can mean C. difficile, a dangerous colon infection. The dose must match kidney function, because too low a dose has led to worse outcomes, so expect frequent kidney blood tests.

Clinical pearls

  • Mention any past serious reaction to a penicillin, cephalosporin or carbapenem antibiotic, since cross-reactions with Avycaz are possible.
  • For abdominal infections it is given together with metronidazole, a second antibiotic that covers gut bacteria Avycaz does not.
  • Avycaz can cause false-positive urine sugar results with some test methods, so glucose oxidase-based tests should be used instead.
  • Report confusion, twitching or seizures right away, especially with kidney problems, since these nervous system reactions have been reported.
How we write & review this content — our editorial policy →
How you get itPrescription only
Comes asInjection
Earliest FDA record2014
Companies listing it with the FDA1
FDA label last updatedApr 30, 2025
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Ceftazidime and Avibactam Injection, written from its FDA label.

What Ceftazidime and Avibactam Injection is used for

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Avycaz (ceftazidime and avibactam for injection) is approved to treat serious bacterial infections caused by susceptible gram-negative bacteria in adults and pediatric patients at least 31 weeks gestational age.

  • Complicated intra-abdominal infections (cIAI): Avycaz, used together with metronidazole, treats serious abdominal infections caused by bacteria such as E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and others.
  • Complicated urinary tract infections (cUTI), including pyelonephritis: Avycaz treats serious urinary tract and kidney infections caused by susceptible gram-negative bacteria including E. coli, K. pneumoniae, and P. aeruginosa.
  • Hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP): Avycaz treats these serious lung infections caused by bacteria such as K. pneumoniae, P. aeruginosa, E. coli, Serratia marcescens, and Haemophilus influenzae.

How Ceftazidime and Avibactam Injection works

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Ceftazidime is a cephalosporin antibiotic that kills bacteria by interfering with their ability to build and maintain their cell walls. Avibactam is a beta-lactamase inhibitor — it blocks the enzymes (called beta-lactamases) that some bacteria make specifically to destroy antibiotics like ceftazidime. By blocking those enzymes, avibactam allows ceftazidime to keep working against bacteria that would otherwise be resistant to it.

Avycaz is only effective against gram-negative bacteria. It should only be used when laboratory testing confirms — or there is strong clinical reason to suspect — that the infection is caused by bacteria susceptible to it. Using antibiotics unnecessarily contributes to drug resistance and makes them less effective over time.

Ceftazidime and Avibactam Injection dosage

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Avycaz is given only as an intravenous (IV) infusion in a hospital or clinical setting — it is not taken by mouth. Each infusion runs over 2 hours, and doses are given every 8 hours. The total length of treatment depends on the type of infection: 5 to 14 days for complicated abdominal infections, and 7 to 14 days for urinary tract infections and pneumonia.

  • Dose is adjusted based on kidney function — patients with reduced kidney function receive lower or less frequent doses.
  • In patients whose kidney function is changing, levels are monitored at least daily and dosing is adjusted as needed.
  • Avycaz should be given after hemodialysis sessions on dialysis days.
  • Pediatric dosing is weight-based and age-based — your child's care team will calculate the right amount.

Dosing details from the FDA-approved label

From the Ceftazidime and Avibactam Injection prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Adults (18 years and older) with CrCl greater than 50 mL/min: cIAI, cUTI including pyelonephritis, and HABP/VABP
    • AVYCAZ 2.5 grams (ceftazidime 2 grams and avibactam 0.5 grams) every 8 hours by intravenous infusion over 2 hours
    • Duration cIAI: 5 to 14 days, cUTI: 7 to 14 days, HABP/VABP: 7 to 14 days
    • For cIAI, used in conjunction with metronidazole 0.5 g intravenously every 8 hours
  • Pediatric patients 2 years to less than 18 years (eGFR greater than 50 mL/min/1.73 m2): cIAI, cUTI including pyelonephritis, HABP/VABP
    • AVYCAZ 62.5 mg/kg (ceftazidime 50 mg/kg and avibactam 12.5 mg/kg) every 8 hours, infused over 2 hours
    • Maximum: 2.5 grams (ceftazidime 2 grams and avibactam 0.5 grams)
    • For cIAI, metronidazole 10 mg/kg intravenously every 8 hours; eGFR 50 or less requires dosage adjustment
  • Pediatric patients 6 months to less than 2 years without renal impairment
    • AVYCAZ 62.5 mg/kg (ceftazidime 50 mg/kg and avibactam 12.5 mg/kg) every 8 hours, infused over 2 hours
    • Insufficient information to recommend dosing with renal impairment in patients younger than 2 years
  • Pediatric patients 3 months to less than 6 months without renal impairment
    • AVYCAZ 50 mg/kg (ceftazidime 40 mg/kg and avibactam 10 mg/kg) every 8 hours, infused over 2 hours
  • Pediatric patients greater than 28 days to less than 3 months without renal impairment
    • AVYCAZ 37.5 mg/kg (ceftazidime 30 mg/kg and avibactam 7.5 mg/kg) every 8 hours, infused over 2 hours
  • Pediatric patients less than or equal to 28 days with GA 31 weeks and older, without renal impairment
    • AVYCAZ 25 mg/kg (ceftazidime 20 mg/kg and avibactam 5 mg/kg) every 8 hours, infused over 2 hours
  • Adults with renal impairment: CrCl 31 to 50 mL/min
    • AVYCAZ 1.25 grams (ceftazidime 1 gram and avibactam 0.25 grams) intravenously every 8 hours, over 2 hours
    • CrCl by Cockcroft-Gault; monitor CrCl at least daily if renal function changes
  • Adults with renal impairment: CrCl 16 to 30 mL/min
    • AVYCAZ 0.94 grams (ceftazidime 0.75 grams and avibactam 0.19 grams) intravenously every 12 hours, over 2 hours
  • Adults with renal impairment: CrCl 6 to 15 mL/min (every 24 hours) and 5 or less (every 48 hours)
    • AVYCAZ 0.94 grams (ceftazidime 0.75 grams and avibactam 0.19 grams) intravenously every 24 hours for CrCl 6 to 15
    • Every 48 hours for CrCl less than or equal to 5
    • Hemodialyzable; administer after hemodialysis on hemodialysis days
  • Pediatric patients 2 years and older with renal impairment (eGFR mL/min/1.73 m2)
    • 31 to 50: 31.25 mg/kg every 8 hours
    • 16 to 30: 23.75 mg/kg every 12 hours
    • 6 to 15: 23.75 mg/kg every 24 hours
    • Less than or equal to 5: 23.75 mg/kg every 48 hours
    • All over 2 hours
    • Maximum: 31 to 50: 1.25 grams; 16 to 30, 6 to 15 and 5 or less: 0.94 grams
    • eGFR by Schwartz bedside formula; administer after hemodialysis on hemodialysis days
Read the label’s full dosing text

2 DOSAGE AND ADMINISTRATION Dosage of AVYCAZ in Adult Patients with Creatinine Clearance (CrCl) greater than 50 mL/min ( 2.1 ) Infection Dose Frequency Infusion Time cIAI * , cUTI including Pyelonephritis, and HABP/VABP AVYCAZ 2.5 grams (ceftazidime 2 grams and avibactam 0.5 grams) Every 8 hours 2 hours * Used in conjunction with metronidazole 0.5 g intravenously every 8 hours in adult cIAI patients Dosage of AVYCAZ in Pediatric Patients aged 2 years to less than 18 years with Estimated Glomerular Filtration Rate (eGFR) greater than 50 mL/min/1.73 m 2 and in Pediatric Patients less than 2 years of age without Renal Impairment ( 2.2 ) Infection Age Range Dose Infusion Time/ Frequency cIAI * , cUTI including Pyelonephritis, HABP/VABP 2 years to less than 18 years AVYCAZ 62.5 mg/kg to a maximum of 2.5 grams (ceftazidime 50 mg/kg and avibactam 12.5 mg/kg to a maximum dose of ceftazidime 2 grams and avibactam 0.5 grams) 2 hours/ Every 8 hours 6 months to less than 2 years AVYCAZ 62.5 mg/kg (ceftazidime 50 mg/kg and avibactam 12.5 mg/kg) 3 months to less than 6 months AVYCAZ 50 mg/kg (ceftazidime 40 mg/kg and avibactam 10 mg/kg) Greater than 28 days a to less than 3 months AVYCAZ 37.5 mg/kg (ceftazidime 30 mg/kg and avibactam 7.5 mg/kg) Less than or equal to 28 days b with GA 31 weeks and older AVYCAZ 25 mg/kg (ceftazidime 20 mg/kg and avibactam 5 mg/kg) * Used in conjunction with metronidazole 10 mg/kg intravenously every 8 hours in pediatric cIAI patients a Includes full-term infants with PNA > 28 days and pre-term infants with corrected age > 28 days. Corrected age is calculated by subtracting the number of weeks born before 40 weeks of gestation from the postnatal age. b Includes neonates PNA ≤ 28 days and pre-term infants with corrected age ≤ 28 days. GA = gestational age and PNA = postnatal age. For treatment of cIAI, metronidazole should be given concurrently Recommended duration of treatment in adult and pediatric patients: ( 2.1 , 2.2 ) cIAI: 5 to 14 days cUTI including pyelonephritis: 7 to 14 days HABP/VABP: 7 to 14 days Dosage adjustment is required in adult patients with creatinine clearance (CrCl) less than or equal to 50 mL/min and in pediatric patients aged 2 years and older with renal impairment. There is insufficient information to recommend a dosing regimen for pediatric patients younger than 2 years of age with renal impairment.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Ceftazidime and Avibactam Injection side effects

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The most commonly reported side effects with Avycaz include:

Common side effects

  • Diarrhea
  • Nausea
  • Vomiting
  • Headache
  • Dizziness
  • Constipation
  • Itching (pruritus)
  • Rash
  • Infusion site reactions (such as phlebitis — irritation at the IV site)

When to get medical help

  • Get medical help right away if you have signs of a severe allergic reaction: hives, swelling of the face or throat, difficulty breathing, or sudden drop in blood pressure
  • Call your doctor if you develop diarrhea during or after treatment — especially if it is severe, watery, or bloody, as this could be a dangerous C. difficile infection
  • Tell your care team immediately if you have seizures, confusion, unusual muscle movements, or loss of consciousness — especially if you have kidney problems
  • Alert your team if you notice decreased urination or other signs of worsening kidney function, as dose adjustments may be needed

Ceftazidime and Avibactam Injection warnings and precautions

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  • Kidney function and dosing: Patients with reduced kidney function must have their Avycaz dose carefully adjusted. In one clinical trial, patients with moderate kidney impairment who received an incorrect (lower-than-recommended) dose had significantly lower cure rates and higher mortality. Kidney function should be monitored at least daily when it is unstable.
  • Serious allergic reactions: Avycaz can cause severe allergic reactions, including anaphylaxis (a life-threatening emergency) and serious skin reactions. Patients with prior allergies to penicillins or other beta-lactam antibiotics may be at higher risk. If a reaction occurs, Avycaz must be stopped immediately.
  • C. difficile-associated diarrhea (CDAD): Like all antibiotics, Avycaz can disrupt normal gut bacteria and allow C. difficile to overgrow, causing diarrhea that can range from mild to life-threatening colitis. This can occur even months after completing treatment.
  • Nervous system reactions: Seizures, confusion, and other neurological events have been reported — particularly in patients with kidney impairment. Correct dosing based on kidney function helps reduce this risk.

Ceftazidime and Avibactam Injection interactions

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Avycaz has a small number of known drug and test interactions to be aware of:

  • Probenecid (used to treat gout): This drug can block the kidneys from clearing avibactam, potentially raising avibactam levels in the body. Co-administration with Avycaz is not recommended.
  • Urine glucose tests: Ceftazidime (one of Avycaz's ingredients) can cause false-positive results on certain urine glucose tests. Tests that use enzymatic glucose oxidase methods should be used to avoid inaccurate readings.

Interactions listed in the FDA-approved label

From the Ceftazidime and Avibactam Injection prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Probenecid: Probenecid inhibits OAT uptake of avibactam by 56% to 70% in vitro and has the potential to decrease the elimination of avibactam when co-administered. Co-administration of AVYCAZ with probenecid is not recommended.
  • Urine glucose tests (drug/laboratory test interaction): Ceftazidime may result in a false-positive reaction for glucose in the urine with certain methods. Use glucose tests based on enzymatic glucose oxidase reactions.
Read the label’s full interactions text

7 DRUG INTERACTIONS 7.1 Probenecid In vitro , avibactam is a substrate of OAT1 and OAT3 transporters which might contribute to the active uptake from the blood compartment, and thereby its excretion. As a potent OAT inhibitor, probenecid inhibits OAT uptake of avibactam by 56% to 70% in vitro and, therefore, has the potential to decrease the elimination of avibactam when co-administered. Because a clinical interaction study of AVYCAZ or avibactam alone with probenecid has not been conducted, co-administration of AVYCAZ with probenecid is not recommended [ see Clinical Pharmacology ( 12.3 ) ] . 7.2 Drug/Laboratory Test Interactions The administration of ceftazidime may result in a false-positive reaction for glucose in the urine with certain methods. It is recommended that glucose tests based on enzymatic glucose oxidase reactions be used.

Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿37 supplements and herbs with documented Ceftazidime and Avibactam Injection interactions, ranked by severity Check Ceftazidime and Avibactam Injection against a supplement or herb →

Before taking Ceftazidime and Avibactam Injection

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  • Cephalosporin or penicillin allergy: Tell your doctor about any past allergic reactions to cephalosporins, penicillins, or carbapenems — there is a risk of cross-reaction.
  • Kidney disease: Dose adjustment is required if kidney function is reduced. Anyone with changing kidney function needs daily monitoring.
  • Pregnancy: There are no adequate studies of Avycaz in pregnant women. It should only be used during pregnancy if clearly necessary, as determined by your doctor.
  • Breastfeeding: Ceftazidime is found in breast milk in small amounts; it is unknown whether avibactam passes into breast milk. Discuss risks and benefits with your doctor.
  • Children: Avycaz is approved for pediatric patients at least 31 weeks gestational age. Dosing is weight- and age-based. There is not enough information to recommend doses for children under 2 years of age with kidney impairment.
  • Older adults: Elderly patients are more likely to have reduced kidney function, which affects how Avycaz is cleared from the body. Dosing should be based on kidney function, not age alone.

Ceftazidime and Avibactam Injection overdose

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If too much Avycaz is given, treatment should be stopped and supportive care started right away. Both ceftazidime and avibactam can be removed from the body using hemodialysis — in studies, about 55% of each drug was removed during a 4-hour dialysis session. There is no specific antidote.

What Ceftazidime and Avibactam Injection does in the body

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For ceftazidime, the amount of time its concentration in the blood stays above the minimum level needed to inhibit bacterial growth is the key factor that determines how well it works. For avibactam, staying above a certain threshold concentration is what best predicts its ability to protect ceftazidime from bacterial resistance enzymes. Testing at high doses found that Avycaz does not meaningfully affect the heart's electrical rhythm (specifically, the QT interval that governs heartbeat timing).

How your body processes Ceftazidime and Avibactam Injection

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Both ceftazidime and avibactam are administered intravenously and distribute into body tissues, including lung fluid. Neither drug is significantly broken down by the body — ceftazidime is excreted 80–90% unchanged by the kidneys, and avibactam is eliminated almost entirely unchanged in the urine (about 97% of a dose recovered in urine). The half-life of ceftazidime is roughly 2.7 to 3.3 hours, and avibactam's is approximately 2.2 to 2.7 hours in adults with normal kidney function. Because both drugs depend heavily on kidney clearance, reduced kidney function significantly affects how long they stay in the body, making dose adjustment essential.

How to store Ceftazidime and Avibactam Injection

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stored at 25°C (77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) . Protect from light. Store in carton until time of use.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

37

Supplements & herbs that interact with Ceftazidime and Avibactam Injection

37 supplements and herbal products have documented interactions with Ceftazidime and Avibactam Injection in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Moderate · 36
  • Minor · 1
AFRICAN WILD POTATO Moderate BACILLUS COAGULANS Moderate Bacillus Subtilis Moderate Banderol Moderate BIFIDOBACTERIUM ANIMALIS SUBSP. LACTIS Moderate BIFIDOBACTERIUM BIFIDUM Moderate BIFIDOBACTERIUM BREVE Moderate BIFIDOBACTERIUM LONGUM Moderate +29 more
Every supplement checked against Ceftazidime and Avibactam Injection — ranked by severity The full interaction hub: 36 moderate · 1 minor · every one linked to its full report. Check Ceftazidime and Avibactam Injection against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

7

Nutrient depletion considerations

Ceftazidime and Avibactam Injection has been associated with lower levels of 7 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

Evidence & significance mix
  • Higher significance · 6
  • Moderate · 1
BIOTIN Insignificant Depletion FOLIC ACID Insignificant Depletion RIBOFLAVIN Insignificant Depletion THIAMINE Insignificant Depletion VITAMIN B12 Insignificant Depletion VITAMIN B6 Insignificant Depletion VITAMIN K Moderate Depletion
See the full Ceftazidime and Avibactam Injection nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Ceftazidime and Avibactam Injection: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Ceftazidime and Avibactam Injection — the kind of thing our pharmacy team would talk through with you at the counter.

Why do I need this specific antibiotic instead of a regular one?

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Avycaz is reserved for serious infections caused by gram-negative bacteria that are difficult to treat — sometimes because they've developed resistance to other antibiotics. The avibactam part of the combination specifically blocks the enzymes bacteria use to neutralize the antibiotic ceftazidime, making it effective when other options might not work. Your doctor chose it based on the type and severity of your infection, likely guided by lab culture results.

What side effects should I actually expect, and which ones should make me call someone right away?

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The most common side effects are digestive — diarrhea, nausea, and vomiting. These are uncomfortable but usually manageable. What you should report immediately is severe or bloody diarrhea (which can signal a serious gut infection called C. difficile), any signs of an allergic reaction like hives, swelling, or trouble breathing, or any new seizures or unusual confusion. If you're in the hospital receiving this, your nurses are already watching for these, but speak up right away if anything feels wrong.

How long will I be on this antibiotic?

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It depends on the type of infection you have. For complicated abdominal infections, treatment typically lasts 5 to 14 days. For urinary tract infections or pneumonia, it's usually 7 to 14 days. Your doctor will decide the right length based on how you're responding. Finish the full course even if you feel better — stopping early can allow the infection to return or worsen.

I have kidney disease — is this safe for me?

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You can still receive Avycaz, but your dose will need to be carefully adjusted based on how well your kidneys are working. Both of the active ingredients leave the body almost entirely through the kidneys, so if your kidneys aren't filtering well, the drugs can build up to higher-than-intended levels and cause side effects. Your care team will check your kidney function at least daily while you're being treated and adjust your dose as needed.

Can I get this antibiotic if I'm allergic to penicillin?

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Possibly — but your doctor needs to know. Avycaz belongs to the cephalosporin class of antibiotics, which is related to penicillin. There is a known risk of cross-reaction, meaning some people with penicillin allergies can also react to cephalosporins. The severity and type of your previous penicillin reaction matters. Your care team will weigh the risks and benefits and may monitor you closely if they decide Avycaz is still the best option for your infection.

I'm pregnant — is this medication safe for my baby?

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There aren't enough studies in pregnant women to say for certain, so Avycaz is only recommended during pregnancy when your doctor determines the benefit clearly outweighs any potential risk. Animal studies did not show harm to fetuses at doses comparable to the human dose, but animal results don't always predict what happens in people. If you're pregnant or think you might be, make sure your entire care team knows so they can make the most informed decision for both you and your baby.

Is Ceftazidime and Avibactam Injection available over the counter?

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No. Ceftazidime and Avibactam Injection is a prescription medicine: every Ceftazidime and Avibactam Injection product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Ceftazidime and Avibactam Injection first available?

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The earliest FDA record we hold for Ceftazidime and Avibactam Injection is from 2014: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Ceftazidime and Avibactam Injection was first used.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Ceftazidime and Avibactam Injection on HelloPharmacist

📊Ceftazidime and Avibactam Injection supplement interactions37 checked — ranked by severity 🌿Drug & Supplement CheckerCeftazidime and Avibactam Injection vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Ceftazidime and Avibactam Injection NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Ceftazidime and Avibactam Injection Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Ceftazidime and Avibactam Injection forms and strengths (how it comes)

Ceftazidime and Avibactam Injection is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Injection

Into a vein
Brands Avycaz
How this form is used
What it may be used for
  • Avycaz is used intravenously to treat complicated intra-abdominal infections (cIAI) caused by susceptible gram-negative bacteria, in combination with metronidazole
  • Avycaz is used intravenously to treat complicated urinary tract infections (cUTI), including pyelonephritis, caused by susceptible gram-negative bacteria
  • Avycaz is used intravenously to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP) caused by susceptible gram-negative bacteria
Important instructions
  • Avycaz is administered as a 2-hour intravenous infusion, typically every 8 hours
  • Avycaz comes as a dry powder that must be reconstituted and then diluted before infusion — it is prepared by healthcare professionals and is not for direct injection without dilution
  • Avycaz dose is adjusted based on kidney function in adults and in children 2 years and older; kidney function should be monitored at least daily when it is changing
  • Avycaz should be administered after hemodialysis on dialysis days, as both ceftazidime and avibactam are removed by hemodialysis
Available strengths 2 strengths
0.5 g / 2 g 2 g / 0.5 g
4 FDA-listed product records ⓘ

Ceftazidime and Avibactam Injection on the U.S. market: products, makers and brands

How Ceftazidime and Avibactam Injection appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

1 company lists 1 Ceftazidime and Avibactam Injection product record with the FDA, mostly as injection; the earliest marketing or approval year on record is 2014. Brand names on the directory include Avycaz; the rest are generics.

1
Dose forms ⓘ
1
Labelers (makers, repackagers, distributors)
1
Brand names
1
FDA-listed product records ⓘ
2014
Earliest FDA record ⓘ

Also listed with the FDA, not a patient dose form: Powder (1) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

How widely Ceftazidime and Avibactam Injection is used (Medicaid data)

A general measure of how commonly Ceftazidime and Avibactam Injection is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Ceftazidime and Avibactam Injection is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

1,753
Medicaid prescriptions filled (Q1–Q4 2025)
$5.6M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Ceftazidime and Avibactam Injection prescribed? Of the 1,601 medications we measure, Ceftazidime and Avibactam Injection ranks #1,203 by Medicaid prescriptions — more than 25% of them.

Where Ceftazidime and Avibactam Injection ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #1,203 of 1,601
#1,198 Candesartan Cilexetil... 1,918 Rx #1,199 Ganciclovir Ophthalmic 1,891 Rx #1,200 Naftifine Topical 1,859 Rx #1,201 Mefenamic Acid 1,776 Rx #1,202 Rotigotine Transdermal... 1,775 Rx #1,203 Ceftazidime and Avibac... 1,753 Rx #1,204 Hydrocodone 1,748 Rx #1,205 Palivizumab Injection 1,742 Rx #1,206 Obinutuzumab Injection 1,741 Rx #1,207 Bosutinib 1,739 Rx #1,208 Trifluridine and Tipir... 1,725 Rx

Utilization by Ceftazidime and Avibactam Injection product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

avibactam 500 MG / ceftazidime 2000 MG Injection

1,753 Medicaid prescriptions (Q1–Q4 2025) 100% of Ceftazidime and Avibactam Injection prescriptions shown $5.6M gross reimbursement (before rebates) ≈ $3,208 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1603840

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Ceftazidime and Avibactam Injection, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 1 of 2 listed Ceftazidime and Avibactam Injection NDCs with Medicaid activity.

Compare Ceftazidime and Avibactam Injection products

A representative set of FDA-listed product records for Ceftazidime and Avibactam Injection — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Strength Route Manufacturer / Labeler Category ⓘ Details
💊Injection
CEFTAZIDIME 0.5 g/1; AVIBACTAM SODIUM 2 g Intravenous Allergan, Inc. NDA View NDC →

Showing 1 of 1 products — FDA National Drug Code Directory. See every product, package size and price: browse all 1 Ceftazidime and Avibactam Injection NDCs →

Ceftazidime and Avibactam Injection recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Ceftazidime and Avibactam recalls since July 2021.

✅No Ceftazidime and Avibactam recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

Ceftazidime and Avibactam Injection brand names

Ceftazidime and Avibactam Injection is sold under one brand name in the FDA directory — Avycaz. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Avycaz

Who makes Ceftazidime and Avibactam Injection: manufacturers and labelers

One company lists Ceftazidime and Avibactam Injection products with the FDA. By number of product records, the largest are Allergan, Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Allergan, Inc. 1

Ceftazidime and Avibactam Injection drug class (RxNorm)

Ceftazidime and Avibactam Injection belongs to the beta Lactamase Inhibitor class.

Pharmacologic class beta Lactamase Inhibitor
How it works beta Lactamase Inhibitors

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Ceftazidime and Avibactam Injection page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Apr 30, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Ceftazidime and Avibactam Injection.
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Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
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Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Ceftazidime and Avibactam Injection after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
1
Finished products in the current FDA directory
1
Companies listing them (makers, repackagers, distributors)
1
FDA labeler codes behind them ⓘ
1
Linked representative label ⓘ
Allergan, Inc.
Linked label effective
Apr 30, 2025
Composite sections available
22
Linked SPL Set ID
d9c2803f-dc9c-4b19-b4a3-8303bc8c15fd
Linked SPL Document ID
b64cc1d6-6d52-4615-82b2-6dcaa9d9fefe
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Allergan, Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →