Bosutinib

Generic name: Pronounced as (boe sue' ti nib)
Brand names
  • Bosulif®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 09/15/2021

Bosutinib is used to treat a certain type of chronic myeloid leukemia (CML; a type of cancer of the white blood cells), including treatment in adults who have been recently found to have this condition and in those who can no longer benefit from other medications for CML or who cannot take these medications because of side effects. Bosutinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.

Bosutinib comes as a tablet to take by mouth. It is usually taken with food once a day. Take bosutinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take bosutinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them. If any of the tablets are broken or crushed, do not touch them with your bare hands.

Your doctor may temporarily or permanently stop your treatment or adjust your dose of bosutinib depending on your response to treatment and any side effects that you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take bosutinib even if you feel well. Do not stop taking bosutinib without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking bosutinib,

  • tell your doctor and pharmacist if you are allergic to bosutinib or any of the ingredients in bosutinib tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain antifungals such as ketoconazole and itraconazole (Sporanox); aprepitant (Emend); certain medications used to treat human immunodeficiency virus (HIV) such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Invirase); medications to reduce stomach acid (proton-pump inhibitors) such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (AcipHex); diltiazem (Cardizem, Cartia, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); nefazodone; rifabutin (Mycobutin); and rifampin (Rifadin, Rimactane in Rifamate, in Rifater). Many other medications may also interact with bosutinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • if you are taking antacids, such as aluminum hydroxide/magnesium hydroxide (Maalox), calcium carbonate (Tums) or calcium carbonate and magnesium (Rolaids) or medications to reduce stomach acid, such as cimetidine (Tagamet), famotidine (Pepcid), or ranitidine (Zantac), take them 2 hours before or 2 hours after you take bosutinib.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have or have ever had high blood pressure, diabetes, or kidney, liver, or heart disease.

  • tell your doctor if you are pregnant or plan to become pregnant. You will need to take a pregnancy test before you start treatment and you should not become pregnant while you are taking bosutinib. You should use an effective form of birth control during treatment with bosutinib and for 2 weeks after your final dose. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking bosutinib, call your doctor. Bosutinib may harm the fetus.

  • tell your doctor if you are breastfeeding. You should not breastfeed while you are taking bosutinib and for 2 weeks after your last dose.

  • you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking bosutinib.

Do not eat grapefruit, drink grapefruit juice, or take any supplement containing grapefruit extract while taking this medication.

Take the missed dose with food as soon as you remember it. However, if it has been more than 12 hours since your last dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Bosutinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • headache

    • loss of appetite

    • tiredness or weakness

    • change in ability to taste food

    • ringing in the ears

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • nausea

    • vomiting

    • diarrhea

    • sudden stomach area pain

    • unexplained bleeding or bruising

    • blood in urine or stool

    • change in the frequency of urination

    • increase or decrease in the amount of urine

    • dizziness

    • fever, sore throat, chills, or other signs of infection

    • shortness of breath and cough

    • chest pain

    • swelling of face, hands, ankles, feet, or lower legs

    • sudden weight gain

    • yellowing of the skin and eyes

    • dark or tea-colored urine

    • hives

    • rash

    • itching

    • difficulty breathing or swallowing

  • Bosutinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to bosutinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The metabolism of Repaglinide can be decreased when combined with Bosutinib.
Montelukast Montelukast The metabolism of Montelukast can be decreased when combined with Bosutinib.
Leflunomide Leflunomide The risk or severity of adverse effects can be increased when Bosutinib is combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Bosutinib can be decreased when combined with Delavirdine.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Bosutinib.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Bosutinib.
Anagrelide Anagrelide The risk or severity of bleeding can be increased when Anagrelide is combined with Bosutinib.
Calcium Carbonate Calcium Carbonate Calcium carbonate can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Bosutinib.
Clopidogrel Clopidogrel The risk or severity of bleeding can be increased when Clopidogrel is combined with Bosutinib.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Bosutinib can be increased when it is combined with Erythromycin.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Bosutinib.
Magnesium Hydroxide Magnesium Hydroxide Magnesium hydroxide can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium Oxide Magnesium Oxide Magnesium oxide can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methylergonovine Methylergonovine The metabolism of Bosutinib can be decreased when combined with Methylergometrine.
Mycophenolate Mycophenolate The risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Bosutinib.
Paregoric Paregoric The metabolism of Morphine can be decreased when combined with Bosutinib.
Prednisone Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Bosutinib.
Ranitidine Ranitidine Ranitidine can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Reserpine Reserpine The serum concentration of Bosutinib can be increased when it is combined with Reserpine.
Tacrolimus Tacrolimus The serum concentration of Bosutinib can be increased when it is combined with Tacrolimus.
Triamcinolone Triamcinolone The metabolism of Bosutinib can be increased when combined with Triamcinolone.
Doxycycline Injection Doxycycline Injection The metabolism of Bosutinib can be decreased when combined with Doxycycline.
Famotidine Injection Famotidine Injection Famotidine can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fluconazole Injection Fluconazole Injection The serum concentration of Bosutinib can be increased when it is combined with Fluconazole.
Interferon Beta-1b Injection Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Bosutinib.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Bosutinib.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be increased when combined with Bosutinib.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Bosutinib can be increased when combined with Methylprednisolone.
Metronidazole Injection Metronidazole Injection The metabolism of Bosutinib can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The metabolism of Morphine can be decreased when combined with Bosutinib.
Zidovudine Injection Zidovudine Injection The risk or severity of adverse effects can be increased when Zidovudine is combined with Bosutinib.
Cyclosporine Cyclosporine Bosutinib may increase the immunosuppressive activities of Cyclosporine.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding can be increased when Enoxaparin is combined with Bosutinib.
Torsemide Torsemide The metabolism of Torasemide can be decreased when combined with Bosutinib.
Olanzapine Olanzapine Olanzapine can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Bosutinib.
Hydroxychloroquine Hydroxychloroquine The risk or severity of adverse effects can be increased when Hydroxychloroquine is combined with Bosutinib.
Orlistat Orlistat The metabolism of Bosutinib can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Bosutinib can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole Pantoprazole can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Temozolomide Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Bosutinib.
Anakinra Anakinra The metabolism of Bosutinib can be increased when combined with Anakinra.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Bosutinib.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding can be increased when Pentosan polysulfate is combined with Bosutinib.
Etanercept Injection Etanercept Injection The metabolism of Bosutinib can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Bosutinib can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Bosutinib.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Bosutinib.
Epinephrine Injection Epinephrine Injection The metabolism of Bosutinib can be decreased when combined with Epinephrine.
Epirubicin Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Bosutinib.
Zonisamide Zonisamide The serum concentration of Bosutinib can be increased when it is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Bosutinib can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Bosutinib.
Glatiramer Injection Glatiramer Injection The risk or severity of adverse effects can be increased when Glatiramer is combined with Bosutinib.
Teriparatide Injection Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Bosutinib.
Atazanavir Atazanavir The metabolism of Atazanavir can be decreased when combined with Bosutinib.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Bosutinib.
Mefloquine Mefloquine The metabolism of Bosutinib can be decreased when combined with Mefloquine.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Bosutinib.
Vardenafil Vardenafil The serum concentration of Bosutinib can be increased when it is combined with Vardenafil.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Bosutinib.
Aprepitant Aprepitant The metabolism of Bosutinib can be decreased when combined with Aprepitant.
Tegaserod Tegaserod The serum concentration of Bosutinib can be increased when it is combined with Tegaserod.
Progesterone Progesterone The metabolism of Bosutinib can be increased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Bosutinib.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Bosutinib.
Infliximab Injection Infliximab Injection The metabolism of Bosutinib can be increased when combined with Infliximab.
Rifaximin Rifaximin The metabolism of Bosutinib can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Bosutinib.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Bosutinib.
Bosentan Bosentan The metabolism of Bosutinib can be increased when combined with Bosentan.
Natalizumab Injection Natalizumab Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Natalizumab.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Bosutinib.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Bosutinib.
Palifermin Palifermin The therapeutic efficacy of Palifermin can be decreased when used in combination with Bosutinib.
Voriconazole Voriconazole The metabolism of Bosutinib can be decreased when combined with Voriconazole.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Bosutinib.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Bosutinib.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Bosutinib.
Deferasirox Deferasirox The metabolism of Bosutinib can be increased when combined with Deferasirox.
Tipranavir Tipranavir The serum concentration of Bosutinib can be increased when it is combined with Tipranavir.
Felbamate Felbamate The metabolism of Bosutinib can be increased when combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Bosutinib can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Bosutinib can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Imatinib can be decreased when combined with Bosutinib.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Bosutinib.
Bevacizumab Injection Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Bosutinib.
Gefitinib Gefitinib The metabolism of Bosutinib can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The serum concentration of Bosutinib can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The metabolism of Bosutinib can be decreased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Bosutinib.
Hepatitis B Vaccine Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Bosutinib.
Influenza Vaccine, Inactivated or Recombinant Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Bosutinib.
Influenza Vaccine, Live Intranasal Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Bosutinib.
Live Shingles (Zoster) Vaccine (ZVL) Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Bosutinib.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Bosutinib.
Posaconazole Posaconazole The metabolism of Bosutinib can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Bosutinib can be decreased when combined with Primaquine.
Rituximab Injection Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Bosutinib.
Darunavir Darunavir The serum concentration of Bosutinib can be increased when it is combined with Darunavir.
Pemetrexed Injection Pemetrexed Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Bosutinib.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Bosutinib.
Vorinostat Vorinostat The risk or severity of adverse effects can be increased when Vorinostat is combined with Bosutinib.
Sorafenib Sorafenib The serum concentration of Bosutinib can be increased when it is combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Bosutinib can be decreased when combined with Sunitinib.
Lapatinib Lapatinib The serum concentration of Bosutinib can be increased when it is combined with Lapatinib.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Bosutinib.
Armodafinil Armodafinil The metabolism of Bosutinib can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection The risk or severity of adverse effects can be increased when Azacitidine is combined with Bosutinib.
Ivermectin Ivermectin The metabolism of Bosutinib can be increased when combined with Ivermectin.
Temsirolimus Temsirolimus The serum concentration of Bosutinib can be increased when it is combined with Temsirolimus.
Nelarabine Injection Nelarabine Injection The risk or severity of adverse effects can be increased when Nelarabine is combined with Bosutinib.
Lenalidomide Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Bosutinib.
Nilotinib Nilotinib The serum concentration of Bosutinib can be increased when it is combined with Nilotinib.
Toremifene Toremifene The serum concentration of Bosutinib can be increased when it is combined with Toremifene.
Bexarotene Bexarotene The metabolism of Bosutinib can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Bosutinib can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Bosutinib can be decreased when combined with Chloramphenicol.
Decitabine Injection Decitabine Injection The risk or severity of adverse effects can be increased when Decitabine is combined with Bosutinib.
Etravirine Etravirine The metabolism of Bosutinib can be increased when combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Bosutinib.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Bosutinib can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Bosutinib can be decreased when combined with Desvenlafaxine.
Tretinoin Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Bosutinib.
Bendamustine Injection Bendamustine Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Bendamustine.
Pilocarpine Pilocarpine The metabolism of Bosutinib can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Certolizumab pegol can be increased when combined with Bosutinib.
Ixabepilone Injection Ixabepilone Injection The metabolism of Bosutinib can be decreased when combined with Ixabepilone.
Irinotecan Injection Irinotecan Injection The metabolism of Bosutinib can be decreased when combined with Irinotecan.
Estramustine Estramustine The risk or severity of adverse effects can be increased when Estramustine is combined with Bosutinib.
Mitotane Mitotane The metabolism of Bosutinib can be increased when combined with Mitotane.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Bosutinib.
Rufinamide Rufinamide The metabolism of Rufinamide can be increased when combined with Bosutinib.
Silodosin Silodosin The serum concentration of Bosutinib can be increased when it is combined with Silodosin.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Bosutinib.
Dexrazoxane Injection Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Bosutinib.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Bosutinib.
Ibritumomab Injection Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Bosutinib.
Milnacipran Milnacipran The metabolism of Bosutinib can be decreased when combined with Milnacipran.
Dexlansoprazole Dexlansoprazole Bosutinib can cause a decrease in the absorption of Dexlansoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Bosutinib.
Prasugrel Prasugrel The risk or severity of bleeding can be increased when Prasugrel is combined with Bosutinib.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Bosutinib.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Bosutinib.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Bosutinib can be decreased when combined with Tolvaptan.
Dronedarone Dronedarone The serum concentration of Bosutinib can be increased when it is combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Pralatrexate.
Romidepsin Injection Romidepsin Injection The metabolism of Bosutinib can be decreased when combined with Romidepsin.
Topotecan Topotecan The metabolism of Bosutinib can be increased when combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Golimumab can be increased when combined with Bosutinib.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Bosutinib.
Asenapine Asenapine Asenapine can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Bosutinib.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Bosutinib.
Denosumab Injection Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Bosutinib.
Dabigatran Dabigatran The risk or severity of bleeding can be increased when Dabigatran is combined with Bosutinib.
Tocilizumab Injection Tocilizumab Injection The metabolism of Bosutinib can be increased when combined with Tocilizumab.
Fingolimod Fingolimod Bosutinib may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection Eribulin Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Eribulin.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Bosutinib.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Bosutinib.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Bosutinib can be decreased when combined with Aldesleukin.
Sipuleucel-T Injection Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Bosutinib.
Belimumab Injection Belimumab Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Belimumab.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Bosutinib.
Roflumilast Roflumilast Roflumilast may increase the immunosuppressive activities of Bosutinib.
Linagliptin Linagliptin The serum concentration of Bosutinib can be increased when it is combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Bosutinib can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The serum concentration of Bosutinib can be increased when it is combined with Glecaprevir.
Potassium Iodide Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Bosutinib.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Bosutinib can be increased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban The serum concentration of Bosutinib can be increased when it is combined with Rivaroxaban.
Ticagrelor Ticagrelor The serum concentration of Bosutinib can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Bosutinib.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Bosutinib.
Vandetanib Vandetanib The serum concentration of Bosutinib can be increased when it is combined with Vandetanib.
Clobazam Clobazam The metabolism of Bosutinib can be increased when combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Bosutinib can be increased when it is combined with Vemurafenib.
Belatacept Injection Belatacept Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Belatacept.
Ivacaftor Ivacaftor The serum concentration of Bosutinib can be increased when it is combined with Ivacaftor.
Basiliximab Injection Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Bosutinib.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Bosutinib.
Crizotinib Crizotinib The serum concentration of Bosutinib can be increased when it is combined with Crizotinib.
Melphalan Injection Melphalan Injection The risk or severity of adverse effects can be increased when Melphalan is combined with Bosutinib.
Cabergoline Cabergoline The metabolism of Bosutinib can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Bosutinib can be decreased when combined with Naloxone.
Ambrisentan Ambrisentan The serum concentration of Bosutinib can be increased when it is combined with Ambrisentan.
Eculizumab Injection Eculizumab Injection The risk or severity of adverse effects can be increased when Eculizumab is combined with Bosutinib.
Fondaparinux Injection Fondaparinux Injection The risk or severity of bleeding can be increased when Fondaparinux is combined with Bosutinib.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Bosutinib.
Iloprost Iloprost The risk or severity of bleeding can be increased when Iloprost is combined with Bosutinib.
Enzalutamide Enzalutamide The serum concentration of Bosutinib can be increased when it is combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Bosutinib can be increased when it is combined with Mirabegron.
Regorafenib Regorafenib The serum concentration of Bosutinib can be increased when it is combined with Regorafenib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Bosutinib can be increased when combined with Corticotropin.
Teriflunomide Teriflunomide The risk or severity of adverse effects can be increased when Bosutinib is combined with Teriflunomide.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Bosutinib.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Bosutinib.
Dimethyl Fumarate Dimethyl Fumarate The risk or severity of adverse effects can be increased when Bosutinib is combined with Dimethyl fumarate.
Ponatinib Ponatinib The serum concentration of Bosutinib can be increased when it is combined with Ponatinib.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Bosutinib.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Bosutinib can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Bosutinib.
Canagliflozin Canagliflozin The serum concentration of Bosutinib can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be increased when combined with Bosutinib.
Trametinib Trametinib The metabolism of Bosutinib can be increased when combined with Trametinib.
Dolutegravir Dolutegravir The serum concentration of Bosutinib can be increased when it is combined with Dolutegravir.
Afatinib Afatinib The serum concentration of Bosutinib can be increased when it is combined with Afatinib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Bosutinib.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Bosutinib.
Perampanel Perampanel The metabolism of Bosutinib can be increased when combined with Perampanel.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Bosutinib.
Lomitapide Lomitapide The serum concentration of Bosutinib can be increased when it is combined with Lomitapide.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Bosutinib.
Obinutuzumab Injection Obinutuzumab Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Obinutuzumab.
Simeprevir Simeprevir The serum concentration of Bosutinib can be increased when it is combined with Simeprevir.
Sofosbuvir Sofosbuvir The serum concentration of Bosutinib can be increased when it is combined with Sofosbuvir.
Apremilast Apremilast The metabolism of Bosutinib can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Ceritinib can be decreased when combined with Bosutinib.
Siltuximab Injection Siltuximab Injection The metabolism of Siltuximab can be increased when combined with Bosutinib.
Eslicarbazepine Eslicarbazepine The metabolism of Bosutinib can be increased when combined with Eslicarbazepine.
Vedolizumab Injection Vedolizumab Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Vedolizumab.
Belinostat Injection Belinostat Injection The risk or severity of adverse effects can be increased when Belinostat is combined with Bosutinib.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Bosutinib.
Testosterone Injection Testosterone Injection The metabolism of Bosutinib can be increased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Bosutinib can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The serum concentration of Bosutinib can be increased when it is combined with Vorapaxar.
Suvorexant Suvorexant The serum concentration of Bosutinib can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Bosutinib can be increased when it is combined with Edoxaban.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Peginterferon beta-1a.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Bosutinib.
Blinatumomab Injection Blinatumomab Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Blinatumomab.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Bosutinib.
Riociguat Riociguat The metabolism of Riociguat can be decreased when combined with Bosutinib.
Lanreotide Injection Lanreotide Injection The metabolism of Bosutinib can be decreased when combined with Lanreotide.
Pirfenidone Pirfenidone The risk or severity of adverse effects can be increased when Pirfenidone is combined with Bosutinib.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Bosutinib.
Secukinumab Injection Secukinumab Injection The metabolism of Secukinumab can be increased when combined with Bosutinib.
Palbociclib Palbociclib The serum concentration of Bosutinib can be increased when it is combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Bosutinib can be increased when combined with Lenvatinib.
Panobinostat Panobinostat The metabolism of Bosutinib can be decreased when combined with Panobinostat.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Dinutuximab.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Bosutinib.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Bosutinib can be increased when it is combined with Isavuconazonium.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Bosutinib.
Flibanserin Flibanserin The serum concentration of Bosutinib can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Bosutinib can be increased when it is combined with Rolapitant.
Prednisolone Prednisolone The metabolism of Bosutinib can be increased when combined with Prednisolone.
Daclatasvir Daclatasvir The serum concentration of Bosutinib can be increased when it is combined with Daclatasvir.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be decreased when combined with Bosutinib.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be decreased when combined with Bosutinib.
Mepolizumab Injection Mepolizumab Injection The risk or severity of adverse effects can be increased when Mepolizumab is combined with Bosutinib.
Trabectedin Injection Trabectedin Injection The metabolism of Bosutinib can be decreased when combined with Trabectedin.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Bosutinib.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Bosutinib.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Bosutinib.
Rifapentine Rifapentine The metabolism of Bosutinib can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Bosutinib can be increased when combined with Lesinurad.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Bosutinib can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Bosutinib can be increased when combined with Dexamethasone.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Bosutinib.
Ixekizumab Injection Ixekizumab Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Ixekizumab.
Venetoclax Venetoclax The serum concentration of Bosutinib can be increased when it is combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Bosutinib can be increased when it is combined with Cobicistat.
Selexipag Selexipag The metabolism of Selexipag can be decreased when combined with Bosutinib.
Rucaparib Rucaparib The serum concentration of Bosutinib can be increased when it is combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Ribociclib can be decreased when combined with Bosutinib.
Brodalumab Injection Brodalumab Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Brodalumab.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Bosutinib.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Bosutinib.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Deflazacort Deflazacort The metabolism of Deflazacort can be increased when combined with Bosutinib.
Ocrelizumab Injection Ocrelizumab Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Ocrelizumab.
Sarilumab Injection Sarilumab Injection The metabolism of Sarilumab can be increased when combined with Bosutinib.
Midostaurin Midostaurin The metabolism of Bosutinib can be increased when combined with Midostaurin.
Neratinib Neratinib The serum concentration of Bosutinib can be increased when it is combined with Neratinib.
Guselkumab Injection Guselkumab Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Guselkumab.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Bosutinib.
Enasidenib Enasidenib The serum concentration of Bosutinib can be increased when it is combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Bosutinib can be increased when it is combined with Inotuzumab ozogamicin.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Bosutinib.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Bosutinib.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Bosutinib.
Betrixaban Betrixaban The serum concentration of Bosutinib can be increased when it is combined with Betrixaban.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be decreased when combined with Bosutinib.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Bosutinib.
Letermovir Letermovir The metabolism of Bosutinib can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin The serum concentration of Bosutinib can be increased when it is combined with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Bosutinib.
Apalutamide Apalutamide The metabolism of Apalutamide can be increased when combined with Bosutinib.
Penicillamine Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Bosutinib.
Fostamatinib Fostamatinib The metabolism of Bosutinib can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The serum concentration of Bosutinib can be increased when it is combined with Avatrombopag.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Bosutinib.
Sodium Zirconium Cyclosilicate Sodium Zirconium Cyclosilicate Sodium zirconium cyclosilicate can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Bosutinib.
Ivosidenib Ivosidenib The serum concentration of Bosutinib can be increased when it is combined with Ivosidenib.
Lusutrombopag Lusutrombopag The serum concentration of Bosutinib can be increased when it is combined with Lusutrombopag.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Bosutinib.
Dacomitinib Dacomitinib The serum concentration of Bosutinib can be increased when it is combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Bosutinib.
Omadacycline Omadacycline The serum concentration of Bosutinib can be increased when it is combined with Omadacycline.
Sarecycline Sarecycline The serum concentration of Bosutinib can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol The metabolism of Bosutinib can be decreased when combined with Stiripentol.
Talazoparib Talazoparib The serum concentration of Bosutinib can be increased when it is combined with Talazoparib.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Bosutinib.
Glasdegib Glasdegib The serum concentration of Bosutinib can be increased when it is combined with Glasdegib.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Bosutinib.
Larotrectinib Larotrectinib The serum concentration of Bosutinib can be increased when it is combined with Larotrectinib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Bosutinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Bosutinib.
Rifamycin Rifamycin The serum concentration of Bosutinib can be increased when it is combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Prucalopride can be decreased when combined with Bosutinib.
Ravulizumab-cwvz Injection Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Ravulizumab.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Emapalumab can be increased when combined with Bosutinib.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Bosutinib.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Caplacizumab is combined with Bosutinib.
Erdafitinib Erdafitinib The serum concentration of Bosutinib can be increased when it is combined with Erdafitinib.
Esomeprazole Injection Esomeprazole Injection Esomeprazole can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Risankizumab-rzaa Injection Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Bosutinib is combined with Risankizumab.
Alpelisib Alpelisib The metabolism of Alpelisib can be decreased when combined with Bosutinib.
Cladribine Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Bosutinib.
Darolutamide Darolutamide The serum concentration of Bosutinib can be increased when it is combined with Darolutamide.
Triclabendazole Triclabendazole The metabolism of Bosutinib can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The serum concentration of Entrectinib can be increased when it is combined with Bosutinib.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Bosutinib.
Istradefylline Istradefylline The serum concentration of Istradefylline can be increased when it is combined with Bosutinib.
Pitolisant Pitolisant The serum concentration of Bosutinib can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Bosutinib can be increased when it is combined with Fedratinib.
Lefamulin Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Bosutinib.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Bosutinib.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Bosutinib.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Bosutinib can be increased when it is combined with Enfortumab vedotin.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Bosutinib.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Bosutinib.
Lasmiditan Lasmiditan The serum concentration of Bosutinib can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Bosutinib can be increased when it is combined with Ubrogepant.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Bosutinib.
Cenobamate Cenobamate The serum concentration of Bosutinib can be decreased when it is combined with Cenobamate.
Ozanimod Ozanimod The risk or severity of adverse effects can be increased when Bosutinib is combined with Ozanimod.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Bosutinib.
Rimegepant Rimegepant The serum concentration of Bosutinib can be increased when it is combined with Rimegepant.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Bosutinib.
Remdesivir Injection Remdesivir Injection The serum concentration of Bosutinib can be increased when it is combined with Remdesivir.
Ripretinib Ripretinib The serum concentration of Bosutinib can be increased when it is combined with Ripretinib.
Capmatinib Capmatinib The serum concentration of Bosutinib can be increased when it is combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Bosutinib can be increased when it is combined with Lemborexant.
Fostemsavir Fostemsavir The serum concentration of Bosutinib can be increased when it is combined with Fostemsavir.
Octreotide Octreotide The serum concentration of Bosutinib can be increased when it is combined with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Bosutinib can be increased when it is combined with Belantamab mafodotin.
Pralsetinib Pralsetinib The serum concentration of Bosutinib can be increased when it is combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Bosutinib can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Bosutinib.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Bosutinib can be increased when combined with Vitamin E.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Bosutinib.
Indomethacin Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Bosutinib.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Bosutinib.
Trazodone Trazodone The serum concentration of Bosutinib can be decreased when it is combined with Trazodone.
Sodium Bicarbonate Sodium Bicarbonate Sodium bicarbonate can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Hydroxyurea Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Bosutinib.
Floxuridine Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Bosutinib.
Phenobarbital Phenobarbital The metabolism of Bosutinib can be increased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The metabolism of Bosutinib can be decreased when combined with Methotrexate.
Primidone Primidone The metabolism of Bosutinib can be increased when combined with Primidone.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Bosutinib.
Diazepam Diazepam The metabolism of Bosutinib can be decreased when combined with Diazepam.
Lorazepam Lorazepam The metabolism of Lorazepam can be decreased when combined with Bosutinib.
Carmustine Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Bosutinib.
Bromocriptine Bromocriptine The metabolism of Bosutinib can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Bosutinib can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Bosutinib can be decreased when combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Bosutinib.
Tetracycline Tetracycline The metabolism of Bosutinib can be decreased when combined with Tetracycline.
Thioguanine Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Bosutinib.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Bosutinib.
Bleomycin Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Bosutinib.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Bosutinib.
Sulfadiazine Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Bosutinib.
Methadone Methadone The metabolism of Methadone can be increased when combined with Bosutinib.
Oxybutynin Oxybutynin The metabolism of Bosutinib can be decreased when combined with Oxybutynin.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Bosutinib.
Orphenadrine Orphenadrine The metabolism of Bosutinib can be decreased when combined with Orphenadrine.
Azathioprine Azathioprine The risk or severity of adverse effects can be increased when Azathioprine is combined with Bosutinib.
Phentermine Phentermine The metabolism of Phentermine can be decreased when combined with Bosutinib.
Sulfasalazine Sulfasalazine The risk or severity of adverse effects can be increased when Sulfasalazine is combined with Bosutinib.
Hydrocortisone Hydrocortisone The metabolism of Bosutinib can be increased when combined with Hydrocortisone.
Lomustine Lomustine The risk or severity of adverse effects can be increased when Lomustine is combined with Bosutinib.
Doxorubicin Doxorubicin The metabolism of Bosutinib can be decreased when combined with Doxorubicin.
Cytarabine Cytarabine The risk or severity of adverse effects can be increased when Cytarabine is combined with Bosutinib.
Mechlorethamine Mechlorethamine The risk or severity of adverse effects can be increased when Mechlorethamine is combined with Bosutinib.
Dactinomycin Dactinomycin The risk or severity of adverse effects can be increased when Dactinomycin is combined with Bosutinib.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Bosutinib.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Bosutinib.
Hydralazine Hydralazine The metabolism of Bosutinib can be decreased when combined with Hydralazine.
Cimetidine Cimetidine Cimetidine can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Bosutinib.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Bosutinib.
Promethazine Promethazine Promethazine can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Daunorubicin Daunorubicin The metabolism of Bosutinib can be decreased when combined with Daunorubicin.
Griseofulvin Griseofulvin The metabolism of Bosutinib can be increased when combined with Griseofulvin.
Digoxin Digoxin The serum concentration of Bosutinib can be increased when it is combined with Digoxin.
Loxapine Loxapine The serum concentration of Bosutinib can be increased when it is combined with Loxapine.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Bosutinib.
Quinine Quinine The serum concentration of Bosutinib can be increased when it is combined with Quinine.
Calcitriol Calcitriol The metabolism of Bosutinib can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Bosutinib can be increased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Chlorothiazide is combined with Bosutinib.
Secobarbital Secobarbital The metabolism of Bosutinib can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Bosutinib.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Bosutinib.
Probenecid Probenecid The metabolism of Bosutinib can be increased when combined with Probenecid.
Quinidine Quinidine The serum concentration of Bosutinib can be increased when it is combined with Quinidine.
Isoniazid Isoniazid The metabolism of Bosutinib can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Bosutinib can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Bosutinib can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The serum concentration of Bosutinib can be increased when it is combined with Tamoxifen.
Mitomycin Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Bosutinib.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Bosutinib.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Bosutinib.
Methimazole Methimazole The therapeutic efficacy of Bosutinib can be decreased when used in combination with Methimazole.
Propylthiouracil Propylthiouracil The therapeutic efficacy of Bosutinib can be decreased when used in combination with Propylthiouracil.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Bosutinib.
Niacin Niacin The metabolism of Bosutinib can be decreased when combined with Niacin.
Methyclothiazide Methyclothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Methyclothiazide is combined with Bosutinib.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of neutropenia and thrombocytopenia can be increased when Hydrochlorothiazide is combined with Bosutinib.
Danazol Danazol The metabolism of Bosutinib can be decreased when combined with Danazol.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Bosutinib.
Amphotericin B Injection Amphotericin B Injection The metabolism of Bosutinib can be decreased when combined with Amphotericin B.
Mercaptopurine Mercaptopurine The risk or severity of adverse effects can be increased when Mercaptopurine is combined with Bosutinib.
Allopurinol Allopurinol The risk or severity of adverse effects can be increased when Allopurinol is combined with Bosutinib.
Clomiphene Clomiphene The serum concentration of Bosutinib can be increased when it is combined with Clomifene.
Fluorouracil Injection Fluorouracil Injection The metabolism of Bosutinib can be decreased when combined with Fluorouracil.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Bosutinib.
Cephalexin Cephalexin The metabolism of Cephalexin can be decreased when combined with Bosutinib.
Dacarbazine Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Bosutinib.
Acetazolamide Acetazolamide The metabolism of Bosutinib can be decreased when combined with Acetazolamide.
Calcitonin Salmon Injection Calcitonin Salmon Injection The therapeutic efficacy of Salmon calcitonin can be decreased when used in combination with Bosutinib.
Bacillus Calmette-Guerin (BCG) Vaccine Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Bosutinib.
Ketoconazole Ketoconazole The serum concentration of Bosutinib can be increased when it is combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Bosutinib can be decreased when combined with Thiotepa.
Vincristine Injection Vincristine Injection The metabolism of Bosutinib can be decreased when combined with Vincristine.
Dipyridamole Dipyridamole The risk or severity of bleeding can be increased when Dipyridamole is combined with Bosutinib.
Vinblastine Vinblastine The metabolism of Bosutinib can be decreased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Bosutinib.
Aspirin Aspirin The risk or severity of bleeding can be increased when Acetylsalicylic acid is combined with Bosutinib.
Chlorambucil Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Bosutinib.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Bosutinib.
Diltiazem Diltiazem The metabolism of Diltiazem can be decreased when combined with Bosutinib.
Nifedipine Nifedipine The metabolism of Bosutinib can be increased when combined with Nifedipine.
Verapamil Verapamil The serum concentration of Bosutinib can be increased when it is combined with Verapamil.
Cisplatin Injection Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Bosutinib.
Piroxicam Piroxicam The metabolism of Piroxicam can be decreased when combined with Bosutinib.
Streptozocin Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Bosutinib.
Etoposide Etoposide The metabolism of Bosutinib can be increased when combined with Etoposide.
Glyburide Glyburide The metabolism of Bosutinib can be decreased when combined with Glyburide.
Dicloxacillin Dicloxacillin The metabolism of Bosutinib can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Bosutinib can be increased when combined with Nafcillin.
Pentoxifylline Pentoxifylline The risk or severity of bleeding can be increased when Pentoxifylline is combined with Bosutinib.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Bosutinib.
Amiodarone Amiodarone The serum concentration of Bosutinib can be increased when it is combined with Amiodarone.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Bosutinib.
Ciprofloxacin Ciprofloxacin The metabolism of Bosutinib can be decreased when combined with Ciprofloxacin.
Diclofenac Diclofenac The metabolism of Diclofenac can be decreased when combined with Bosutinib.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Bosutinib.
Clozapine Clozapine The risk or severity of neutropenia can be increased when Bosutinib is combined with Clozapine.
Idarubicin Idarubicin The risk or severity of adverse effects can be increased when Idarubicin is combined with Bosutinib.
Fludarabine Injection Fludarabine Injection The risk or severity of adverse effects can be increased when Fludarabine is combined with Bosutinib.
Pentostatin Injection Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Bosutinib.
Clarithromycin Clarithromycin The serum concentration of Bosutinib can be increased when it is combined with Clarithromycin.
Felodipine Felodipine The metabolism of Bosutinib can be decreased when combined with Felodipine.
Pravastatin Pravastatin The serum concentration of Bosutinib can be increased when it is combined with Pravastatin.
Simvastatin Simvastatin The serum concentration of Bosutinib can be increased when it is combined with Simvastatin.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Bosutinib.
Teniposide Injection Teniposide Injection The metabolism of Bosutinib can be decreased when combined with Teniposide.
Itraconazole Itraconazole The serum concentration of Bosutinib can be increased when it is combined with Itraconazole.
Rifabutin Rifabutin The metabolism of Bosutinib can be increased when combined with Rifabutin.
Bisoprolol Bisoprolol The serum concentration of Bosutinib can be increased when it is combined with Bisoprolol.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Bosutinib.
Isradipine Isradipine The metabolism of Bosutinib can be decreased when combined with Isradipine.
Omeprazole Omeprazole Bosutinib can cause a decrease in the absorption of Omeprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cisapride Cisapride The metabolism of Bosutinib can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Bosutinib.
Nizatidine Nizatidine Nizatidine can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Famciclovir Famciclovir The metabolism of Famciclovir can be decreased when combined with Bosutinib.
Fluvoxamine Fluvoxamine The metabolism of Bosutinib can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The metabolism of Bosutinib can be decreased when combined with Nefazodone.
Losartan Losartan The metabolism of Bosutinib can be decreased when combined with Losartan.
Tramadol Tramadol The metabolism of Tramadol can be decreased when combined with Bosutinib.
Vinorelbine Injection Vinorelbine Injection The metabolism of Bosutinib can be decreased when combined with Vinorelbine.
Carboplatin Injection Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Bosutinib.
Lansoprazole Lansoprazole Bosutinib can cause a decrease in the absorption of Lansoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ifosfamide Injection Ifosfamide Injection The metabolism of Bosutinib can be increased when combined with Ifosfamide.
Pegaspargase Injection Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Bosutinib.
Nicardipine Nicardipine The metabolism of Nicardipine can be decreased when combined with Bosutinib.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Bosutinib.
Saquinavir Saquinavir The serum concentration of Bosutinib can be increased when it is combined with Saquinavir.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding can be increased when Dalteparin is combined with Bosutinib.
Anastrozole Anastrozole The metabolism of Anastrozole can be decreased when combined with Bosutinib.
Gemcitabine Injection Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Bosutinib.
Ritonavir Ritonavir The serum concentration of Bosutinib can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Bosutinib can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Bosutinib.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Bosutinib.
Mirtazapine Mirtazapine The metabolism of Bosutinib can be decreased when combined with Mirtazapine.
Topiramate Topiramate The metabolism of Bosutinib can be increased when combined with Topiramate.
Fexofenadine Fexofenadine The serum concentration of Bosutinib can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Bosutinib.
Carvedilol Carvedilol The serum concentration of Bosutinib can be increased when it is combined with Carvedilol.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Bosutinib.
Bicalutamide Bicalutamide The metabolism of Bosutinib can be decreased when combined with Bicalutamide.
Propafenone Propafenone The serum concentration of Bosutinib can be increased when it is combined with Propafenone.
Raloxifene Raloxifene The metabolism of Bosutinib can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Bosutinib.
Paroxetine Paroxetine The metabolism of Bosutinib can be decreased when combined with Paroxetine.
Citalopram Citalopram The metabolism of Bosutinib can be decreased when combined with Citalopram.
Capecitabine Capecitabine The risk or severity of adverse effects can be increased when Capecitabine is combined with Bosutinib.
Efavirenz Efavirenz The metabolism of Bosutinib can be increased when combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Bosutinib can be increased when it is combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Pioglitazone can be decreased when combined with Bosutinib.
Trastuzumab Injection Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Bosutinib.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Bosutinib.
Rosiglitazone Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Bosutinib.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Bosutinib.
Aluminum Hydroxide Aluminum Hydroxide Aluminum hydroxide can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rabeprazole Rabeprazole Rabeprazole can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Terbinafine Terbinafine The metabolism of Terbinafine can be increased when combined with Bosutinib.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

Still Confused? Ask the pharmacist a question here!