Drug & supplement interaction

Lactiplantibacillus Plantarum + Phenylephrine

Phenylephrine brand names: Gilchew, AH Chew D, Gilchew IR, Sudafed PE, Biorphen.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Lactiplantibacillus Plantarum and Phenylephrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Lactiplantibacillus Plantarum and Phenylephrine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Phenylephrine and Lactiplantibacillus Plantarum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lactiplantibacillus Plantarum safety at a glance

Lactiplantibacillu... overall Use caution Generally well tolerated in healthy people, but people with weak immune systems or serious illness should be cautious.

Pregnancy Possibly Safe When used orally and appropriately. Lactiplantibacillus plantarum (Lp299v, DSM 9843) has been used with apparent safety in doses of 10 billion colony-forming un... Read the full pregnancy detail

Breastfeeding Use caution Limited safety data exist, so use only with guidance from your healthcare provider.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Phenylephrine and Lactiplantibacillus Plantarum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Phenylephrine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Phenylephrine is filed under 5 classifications — including alpha-adrenergic agonists, stimulant drugs, serotonergic drugs. Lactiplantibacillus Plantarum has documented interactions with 1 drug class — the most serious being antibiotic drugs (moderate) — and none of Phenylephrine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Lactiplantibacillus Plantarum Does Interact With Other Medications

Lactiplantibacillus Plantarum has 182 moderate known drug interactions in our database — Phenylephrine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 182 No known interaction 2,648 (incl. Phenylephrine)

Taking anything else?

Check Another of Your Medications Against Lactiplantibacillus Plantarum

Covers the 2,830 medications we’ve checked against Lactiplantibacillus Plantarum. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Lactiplantibacillus Plantarum and Phenylephrine May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

Nausea Additional detail
Lactiplantibacillus Plantarum
“Orally, taking Lactiplantibacillus plantarum may cause gastrointestinal side effects including diarrhea, loose stools, nausea, stomach pain, rumbling, bloating, and flatulence; however, these events are uncommon.”

Lactiplantibacillus Plantarum · Natural Medicines adverse-effect record, reported in diarrhea.
6 sources cited

90271. Krag A, Munkholm P, Israelsen H, von Ryberg B, Andersen KK, Bendtsen F. Profermin is efficacious in patients with active ulcerative colitis--a randomized controlled trial. Inflamm Bowel Dis. 2013;19(12):2584-92. PubMed

107497. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete

107556. Lazou Ahrén I, Berggren A, Teixeira C, Martinsson Niskanen T, Larsson N. Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, doub

107557. Busch R, Gruenwald J, Dudek S. Randomized, double blind and placebo controlled study using a combination of two probiotic lactobacilli to alleviate symptoms and frequency of common cold. Food Nutr Sci 2013;4(11A):13-2. DOI

112064. Canaviri-Paz P, Oscarsson E, Kjellström A, Olsson H, Jois C, Håkansson Å. Effects on Microbiota Composition after Consumption of Quinoa Beverage Fermented by a Novel Xylose-Metabolizing L. plantarum Strain. Nutrients 2021;13(10):3318. PubMed

111993. Bengtsson J, Adlerberth I, Östblom A, Saksena P, Öresland T, Börjesson L. Effect of probiotics (Lactobacillus plantarum 299 plus Bifidobacterium Cure21) in patients with poor ileal pouch function: a randomised controlled trial. Scand J Gastroenterol 2016;
Phenylephrine

Listed in the ADVERSE REACTIONS section of the FDA label for Phenylephrine. Read the label on DailyMed ›

Reported for Lactiplantibacillus Plantarum but not commonly for Phenylephrine: diarrhea, stomach pain, bloating or gas and a higher chance of infection.

Effects for Phenylephrine come from the ADVERSE REACTIONS section of its FDA label; effects for Lactiplantibacillus Plantarum come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Lactiplantibacillus Plantarum in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used orally and appropriately. Lactiplantibacillus plantarum (Lp299v, DSM 9843) has been used with apparent safety in doses of 10 billion colony-forming units (CFUs) daily in combination with iron, ascorbic acid, and folic acid daily from 10-12 weeks' gestation until delivery.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Lactiplantibacillus Plantarum or Phenylephrine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Lactiplantibacillus Plantarum or Phenylephrine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Phenylephrine

This page covers Lactiplantibacillus Plantarum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Phenylephrine page lists 81 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Lithium (major), Peyote (major) and Rauvolfia Vomitoria (major).

By severity: 6 major · 60 moderate · 15 minor.

From our pharmacist’s overview on the Phenylephrine page

“If you take phenylephrine (Sudafed PE, Biorphen) for congestion, treat this list as one that needs real attention, since six of its 81 entries carry a major rating. Phenylephrine tightens blood vessels to clear your nose, and more than half of the interactions here come from stimulant ingredients, ephedra above all, that can push blood…”

Reviewed by 2 · Jul 18, 2026

Open the Phenylephrine interaction page

How much people look this up

Where Lactiplantibacillus Plantarum and Phenylephrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lactiplantibacillus Plantarum

Steady interest

#857 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Phenylephrine

Top 25%

#604 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lactiplantibacillus Plantarum reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Lactiplantibacillus Plantarum and Phenylephrine records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Lactiplantibacillus Plantarum

What is Lactiplantibacillus Plantarum?

Digestive health and regularity
Irritable bowel syndrome (IBS) symptoms
Bloating and gas
Immune support
Restoring gut bacteria after antibiotics

Lactiplantibacillus plantarum is a 'friendly' bacterium (probiotic) found in fermented foods and many supplements, studied mainly for digestive health. It is generally well tolerated in healthy people, but evidence is mixed and strain-specific, so benefits are not guaranteed. Talk to your pharmacist or doctor before starting, especially if you have a weakened immune system.

Lactiplantibacillus plantarum · Lactobacillaceae · Live bacterial cells (probiotic culture) · Capsules, tablets, powders, fermented foods, drinks, and combination probiotic products

An interaction check asks whether these two react with each other — it does not ask whether Lactiplantibacillus Plantarum is a good idea for someone in your situation. Here is what our Lactiplantibacillus Plantarum record says about it on its own.

Lactiplantibacillus Plantarum: dosing

There is no single official dose for L. plantarum. Probiotic amounts are usually measured in colony-forming units (CFU), and products vary widely in how much they contain and which strain they use.The best approach is to follow the directions on the product label. They can help you choose a reputable product and check that it is appropriate for your health situation.

From our Lactiplantibacillus Plantarum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lactiplantibacillus Plantarum monograph & all interactions

Medication

About Phenylephrine

What Is Phenylephrine Used For?

Brand names: Gilchew, AH Chew D, Gilchew IR, Sudafed PE, Biorphen

Phenylephrine is used in a number of different forms for different purposes. Intravenous (IV) phenylephrine — including products like Biorphen and Immphentiv — is given in hospital settings to raise blood pressure in adults when it drops dangerously low due to blood vessel widening (vasodilation), such as during anesthesia. Phenylephrine Hydrochloride Injection 10 mg/mL is also approved for use in septic shock (a life-threatening infection that causes a severe drop in blood pressure).

Nasal spray and drop products (such as Neo-Synephrine and Equate Nasal) temporarily relieve nasal congestion from colds, hay fever, or upper respiratory allergies. Ophthalmic (eye drop) solutions dilate the pupil for eye exams. Rectal suppository products (such as Preparation H and ReVIVOL-XR) help relieve itching, burning, and discomfort associated with hemorrhoids.

Most-Reported Side Effects for Phenylephrine

From FAERS, the FDA’s public side-effect reporting system (221,388 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 20,609 reports

Headache 17,301 reports

Nausea 16,925 reports

Diarrhea 14,221 reports

Dyspnea 13,719 reports

See full Phenylephrine drug information

Keep checking

Other Drugs & Lactiplantibacillus Plantarum

Browse every other medication we’ve checked against Lactiplantibacillus Plantarum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

182Moderate

0Minor

2,647No known interaction

182 Moderate 2,647 No interaction

Moderate

182 interactions

Showing 60 of 182 moderate interactions — see all 182 on the Lactiplantibacillus Plantarum page.

No interaction 2,647 drugs checked — show the list

We also checked Lactiplantibacillus Plantarum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,647 medications checked with no known interaction — see the full Lactiplantibacillus Plantarum list.

See the full Lactiplantibacillus Plantarum interactions page

See every supplement checked against Phenylephrine, ranked by severity

Evidence & sources

Lactiplantibacillus Plantarum References

The 12 references that drive our Lactiplantibacillus Plantarum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
Ducrotté P, Sawant P, Jayanthi V. Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol 2012;18(30):4012-8.
Krag A, Munkholm P, Israelsen H, von Ryberg B, Andersen KK, Bendtsen F. Profermin is efficacious in patients with active ulcerative colitis--a randomized controlled trial. Inflamm Bowel Dis. 2013;19(12):2584-92. PubMed
Topcuoglu S, Gursoy T, Ovali F, Serce O, Karatekin G. A new risk factor for neonatal vancomycin-resistant Enterococcus colonisation: bacterial probiotics. J Matern Fetal Neonatal Med. 2015;28(12):1491-4. PubMed
Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
Axling U, Önning G, Martinsson Niskanen T, Larsson N, Hansson SR, Hulthén L. The effect of Lactiplantibacillus plantarum 299v together with a low dose of iron on iron status in healthy pregnant women: A randomized clinical trial. Acta Obstet Gynecol Scand
Matsuura H, Kiura Y, Ito T, et al. Lactobacillus bacteremia: a diagnostic clue of rectal cancer. QJM. 2021;114(2):122-123. PubMed
Lazou Ahrén I, Berggren A, Teixeira C, Martinsson Niskanen T, Larsson N. Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, doub
Busch R, Gruenwald J, Dudek S. Randomized, double blind and placebo controlled study using a combination of two probiotic lactobacilli to alleviate symptoms and frequency of common cold. Food Nutr Sci 2013;4(11A):13-2. DOI
Bengtsson J, Adlerberth I, Östblom A, Saksena P, Öresland T, Börjesson L. Effect of probiotics (Lactobacillus plantarum 299 plus Bifidobacterium Cure21) in patients with poor ileal pouch function: a randomised controlled trial. Scand J Gastroenterol 2016;
Canaviri-Paz P, Oscarsson E, Kjellström A, Olsson H, Jois C, Håkansson Å. Effects on Microbiota Composition after Consumption of Quinoa Beverage Fermented by a Novel Xylose-Metabolizing L. plantarum Strain. Nutrients 2021;13(10):3318. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lactiplantibacillus Plantarum and Phenylephrine Together: Common Questions

Is it safe to take Lactiplantibacillus Plantarum with Phenylephrine?

We do not list a known interaction between Lactiplantibacillus Plantarum and Phenylephrine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Lactiplantibacillus Plantarum and Phenylephrine have any of the same side effects?

Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

How was the Lactiplantibacillus Plantarum and Phenylephrine combination checked?

Interactions in our licensed database are recorded against drug classes. Phenylephrine is filed under 5 classifications, and Lactiplantibacillus Plantarum has documented interactions with 1 drug class — none of Phenylephrine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Lactiplantibacillus Plantarum interact with any other medications?

Yes. Lactiplantibacillus Plantarum has 182 documented drug interactions in our database — Phenylephrine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Phenylephrine interact with any supplements?

Yes. Phenylephrine has documented interactions with 81 supplements in our database — Lactiplantibacillus Plantarum is not one of them. The Phenylephrine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lactiplantibacillus Plantarum monograph Uses, safety profile, and every drug interaction in one place Phenylephrine drug information The full plain-English guide to this medication Phenylephrine supplement interactions Every supplement checked against Phenylephrine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 12 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Phenylephrine and Lactiplantibacillus Plantarum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.