NyQuil With Gabapentin - Interaction Details

In our latest question and answer, our pharmacist discusses the combined use of gabapentin and NyQuil.

Question

I take gabapentin for nerve pain. I have occasional trouble sleeping and want to know if it is safe to take NyQuil once in a while with it.

Asked by Sarah On Apr 11, 2023

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Apr 11, 2023
Last updated May 04, 2024

Key points

  • Combining NyQuil and gabapentin can increase the risk of certain side effects, such as dizziness, drowsiness, and impaired coordination, due to the sedating antihistamine doxylamine in NyQuil and the dose-dependent sedative effects of gabapentin.
  • It's important to be cautious and aware of the potential for increased side effects, follow recommended dosages, and avoid activities that require mental alertness or physical coordination until you know how the combination affects you.

Answer

There is no known interaction between gabapentin and NyQuil. However, it's important to note that NyQuil contains several active ingredients, including doxylamine, which is a sedating antihistamine. Gabapentin is well known to have sedative side effects, especially at higher doses. Therefore, taking NyQuil with gabapentin can increase the risk of certain side effects, such as dizziness, drowsiness, and impaired coordination.

NyQuil Contains Doxylamine, A Sedating Antihistamine

There are several different 'NyQuil' products on the market. The two most popular ones are:

  • NyQuil
  • NyQuil Severe

These products contain:

  • Acetaminophen (analgesic)
  • Doxylamine (sedating antihistamine)
  • Dextromethorphan (cough suppressant)

NyQuil Severe adds phenylephrine, a nasal decongestant.

Now, none of the ingredients in NyQuil products directly interact with gabapentin, but, as mentioned in the section above, the sedative effects of doxylamine could potentiate the sedative side effects of gabapentin.

Gabapentin Can Cause Sedation

Gabapentin is a medication that is primarily used to treat nerve pain, such as pain caused by shingles or diabetic neuropathy. It is also used to treat seizures in some cases.

Two of the more well-known side effects of gabapentin are sedation and dizziness.

The incidence rate of the side effects varies depending on the dose and duration of treatment, as well as other individual factors (such as age). If gabapentin is combined with other medications that can cause sedation and dizziness, the risk and severity of these side effects can be increased.

Combining NyQuil And Gabapentin

So, to reiterate, the concern with combining NyQuil and gabapentin is the risk of additive sedation and dizziness.

If you are taking both of these medications at night, the additive sedative effects may not be that much of a concern, but it is still important to be cautious and aware of the potential for increased drowsiness, dizziness, and impaired cognitive function.

It is important to follow the recommended dosages for both medications and to avoid activities that require mental alertness or physical coordination, such as driving or operating heavy machinery until you know how the combination affects you.

Final Words

Thanks for reaching out to us and I hope this answer provided what you were looking for!

References

  • Neurontin Prescribing Information, AccessFDA
  • Doxylamine Monograph, PubMed

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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