Drug & supplement interaction

Lactiplantibacillus Plantarum + Dexamethasone

Dexamethasone brand names: Decadron, Hexadrol, Dexone, Ozurdex, Dexycu, and others.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Lactiplantibacillus Plantarum and Dexamethasone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Interaction report

Lactiplantibacillus Plantarum and Dexamethasone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dexamethasone and Lactiplantibacillus Plantarum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lactiplantibacillus Plantarum safety at a glance

Lactiplantibacillu... overall Use caution Generally well tolerated in healthy people, but people with weak immune systems or serious illness should be cautious.
Pregnancy Possibly Safe When used orally and appropriately. Lactiplantibacillus plantarum (Lp299v, DSM 9843) has been used with apparent safety in doses of 10 billion colony-forming un... Read the full pregnancy detail
Breastfeeding Use caution Limited safety data exist, so use only with guidance from your healthcare provider.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dexamethasone and Lactiplantibacillus Plantarum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Dexamethasone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Dexamethasone is filed under 8 classifications — including corticosteroids, cytochrome p450 2b6 (cyp2b6) substrates, cytochrome p450 3a4 (cyp3a4) inducers. Lactiplantibacillus Plantarum has documented interactions with 1 drug class — the most serious being antibiotic drugs (moderate) — and none of Dexamethasone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Lactiplantibacillus Plantarum Does Interact With Other Medications

Lactiplantibacillus Plantarum has 182 moderate known drug interactions in our database — Dexamethasone isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against Lactiplantibacillus Plantarum

Covers the 2,830 medications we’ve checked against Lactiplantibacillus Plantarum. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Lactiplantibacillus Plantarum and Dexamethasone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on reported in 4.6% of FDA reports for Dexamethasone Additional detail

    Lactiplantibacillus Plantarum

    “Since Lactiplantibacillus plantarum preparations contain live and active microorganisms, there is some concern that they might cause pathogenic infection in some patients. Lactobacilli species, including L. plantarum, have been isolated in some cases of bacteremia, sepsis, splenic abscess, endocarditis, necrotizing fasciitis, pancreatic necrosis, and meningoencephalitis. Most cases of L.”

    Lactiplantibacillus Plantarum · Natural Medicines adverse-effect record, reported in cancer.

    3 sources cited
    1. 107543. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
    2. 107551. Matsuura H, Kiura Y, Ito T, et al. Lactobacillus bacteremia: a diagnostic clue of rectal cancer. QJM. 2021;114(2):122-123. PubMed
    3. 96890. Topcuoglu S, Gursoy T, Ovali F, Serce O, Karatekin G. A new risk factor for neonatal vancomycin-resistant Enterococcus colonisation: bacterial probiotics. J Matern Fetal Neonatal Med. 2015;28(12):1491-4. PubMed

    Dexamethasone

    Listed in the ADVERSE REACTIONS section of the FDA label for Dexamethasone, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Dizziness Additional detail

    Lactiplantibacillus Plantarum

    “Orally, use of Lactiplantibacillus plantarum 299v 10 billion colony-forming units daily has been associated with one case of transient vertigo in one clinical trial.”

    Lactiplantibacillus Plantarum · Natural Medicines adverse-effect record, reported in vertigo.

    1 source cited
    1. 90249. Ducrotté P, Sawant P, Jayanthi V. Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol 2012;18(30):4012-8.

    Dexamethasone

    Listed in the ADVERSE REACTIONS section of the FDA label for Dexamethasone. Read the label on DailyMed ›

  • Nausea reported in 4.8% of FDA reports for Dexamethasone Additional detail

    Lactiplantibacillus Plantarum

    “Orally, taking Lactiplantibacillus plantarum may cause gastrointestinal side effects including diarrhea, loose stools, nausea, stomach pain, rumbling, bloating, and flatulence; however, these events are uncommon.”

    Lactiplantibacillus Plantarum · Natural Medicines adverse-effect record, reported in diarrhea.

    6 sources cited
    1. 90271. Krag A, Munkholm P, Israelsen H, von Ryberg B, Andersen KK, Bendtsen F. Profermin is efficacious in patients with active ulcerative colitis--a randomized controlled trial. Inflamm Bowel Dis. 2013;19(12):2584-92. PubMed
    2. 107497. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
    3. 107556. Lazou Ahrén I, Berggren A, Teixeira C, Martinsson Niskanen T, Larsson N. Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, doub
    4. 107557. Busch R, Gruenwald J, Dudek S. Randomized, double blind and placebo controlled study using a combination of two probiotic lactobacilli to alleviate symptoms and frequency of common cold. Food Nutr Sci 2013;4(11A):13-2. DOI
    5. 112064. Canaviri-Paz P, Oscarsson E, Kjellström A, Olsson H, Jois C, Håkansson Å. Effects on Microbiota Composition after Consumption of Quinoa Beverage Fermented by a Novel Xylose-Metabolizing L. plantarum Strain. Nutrients 2021;13(10):3318. PubMed
    6. 111993. Bengtsson J, Adlerberth I, Östblom A, Saksena P, Öresland T, Börjesson L. Effect of probiotics (Lactobacillus plantarum 299 plus Bifidobacterium Cure21) in patients with poor ileal pouch function: a randomised controlled trial. Scand J Gastroenterol 2016;

    Dexamethasone

    Listed in the ADVERSE REACTIONS section of the FDA label for Dexamethasone, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Lactiplantibacillus Plantarum but not commonly for Dexamethasone: diarrhea, stomach pain and bloating or gas.

Effects for Dexamethasone come from the ADVERSE REACTIONS section of its FDA label; effects for Lactiplantibacillus Plantarum come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 308,307 voluntary FDA FAERS reports for Dexamethasone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Lactiplantibacillus Plantarum in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used orally and appropriately. Lactiplantibacillus plantarum (Lp299v, DSM 9843) has been used with apparent safety in doses of 10 billion colony-forming units (CFUs) daily in combination with iron, ascorbic acid, and folic acid daily from 10-12 weeks' gestation until delivery.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Dexamethasone Is Prescribed For, and What Lactiplantibacillus Plantarum Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Dexamethasone is a prescription medicine with approved uses on its FDA label. Lactiplantibacillus Plantarum is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Dexamethasone is prescribed for: Dexamethasone is used to treat a wide range of conditions depending on the form and route. Oral tablets and solutions treat severe allergic reactions (such as asthma, contact dermatitis, and seasonal allergic rhinitis), inflammatory skin diseases, endocrine disorders including adrenal insufficiency and congenital adrenal hyperplasia, gastrointestinal diseases such as ulcerative colitis and regional enteritis, blood disorders, rheumatic conditions, kidney disease, and respiratory conditions including tuberculosis complications. Hemady (oral tablet) is specifically approved, in combination with other medicines, for multiple myeloma in adults. TaperDex (6-day and 12-day oral tablet packs) are used for the same broad range of allergic, inflammatory, and endocrine conditions.

Read the rest of what Dexamethasone is prescribed for

Injectable forms (intramuscular and intravenous) are used when oral treatment is not possible, covering endocrine emergencies, shock, rheumatic disorders, and more. Eye-specific products treat different conditions: Dextenza (intracanalicular insert) treats eye inflammation and pain after eye surgery and itching from allergic conjunctivitis. Ozurdex (intravitreal implant) treats macular edema from retinal vein occlusion and diabetic macular edema, and non-infectious uveitis in the back of the eye. Dexycu (intraocular injection) treats inflammation after eye surgery. Maxidex (ophthalmic suspension) and dexamethasone sodium phosphate eye drops treat steroid-responsive inflammatory conditions of the eye. The opht

Lactiplantibacillus Plantarum has been studied for:

  • Ulcerative colitis Natural Medicines rates the evidence for Lactiplantibacillus Plantarum: Possibly Effective Read what the research shows

    Lactiplantibacillus Plantarum for ulcerative colitis

    Oral Lactiplantibacillus plantarum, alone or in combination with other probiotics, seems to improve remission rates and prevent symptom relapse when used in combination with standard therapy.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Dexamethasone on your own; if you are taking Lactiplantibacillus Plantarum for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Lactiplantibacillus Plantarum or Dexamethasone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Lactiplantibacillus Plantarum or Dexamethasone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Dexamethasone

This page covers Lactiplantibacillus Plantarum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dexamethasone page lists 221 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lily-of-the-valley (major), St. John's Wort (major) and Acacia Rigidula (moderate).

By severity: 4 major · 182 moderate · 35 minor.

From our pharmacist’s overview on the Dexamethasone page

“People take dexamethasone for serious reasons, a chemotherapy course, an autoimmune flare, brain swelling, so I want anyone on it to give its 221 supplement interactions genuine attention, starting with the four rated major. Grapefruit and St.”

Reviewed by 2 · Jul 18, 2026

Open the Dexamethasone interaction page

How much people look this up

Where Lactiplantibacillus Plantarum and Dexamethasone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lactiplantibacillus Plantarum
Steady interest

#971 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dexamethasone
Top 10%

#233 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lactiplantibacillus Plantarum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Lactiplantibacillus Plantarum and Dexamethasone records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lactiplantibacillus Plantarum

What is Lactiplantibacillus Plantarum?

  • Digestive health and regularity
  • Irritable bowel syndrome (IBS) symptoms
  • Bloating and gas
  • Immune support
  • Restoring gut bacteria after antibiotics

Lactiplantibacillus plantarum is a 'friendly' bacterium (probiotic) found in fermented foods and many supplements, studied mainly for digestive health. It is generally well tolerated in healthy people, but evidence is mixed and strain-specific, so benefits are not guaranteed. Talk to your pharmacist or doctor before starting, especially if you have a weakened immune system.

Lactiplantibacillus plantarum · Lactobacillaceae · Live bacterial cells (probiotic culture) · Capsules, tablets, powders, fermented foods, drinks, and combination probiotic products

An interaction check asks whether these two react with each other — it does not ask whether Lactiplantibacillus Plantarum is a good idea for someone in your situation. Here is what our Lactiplantibacillus Plantarum record says about it on its own.

Lactiplantibacillus Plantarum: dosing

There is no single official dose for L. plantarum. Probiotic amounts are usually measured in colony-forming units (CFU), and products vary widely in how much they contain and which strain they use.The best approach is to follow the directions on the product label. They can help you choose a reputable product and check that it is appropriate for your health situation.

From our Lactiplantibacillus Plantarum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lactiplantibacillus Plantarum monograph & all interactions
Medication

About Dexamethasone

What Is Dexamethasone Used For?

Brand names: Decadron, Hexadrol, Dexone, Ozurdex, Dexycu, Hemady, Dextenza

Dexamethasone is used to treat a wide range of conditions depending on the form and route. Oral tablets and solutions treat severe allergic reactions (such as asthma, contact dermatitis, and seasonal allergic rhinitis), inflammatory skin diseases, endocrine disorders including adrenal insufficiency and congenital adrenal hyperplasia, gastrointestinal diseases such as ulcerative colitis and regional enteritis, blood disorders, rheumatic conditions, kidney disease, and respiratory conditions including tuberculosis complications. Hemady (oral tablet) is specifically approved, in combination with other medicines, for multiple myeloma in adults. TaperDex (6-day and 12-day oral tablet packs) are used for the same broad range of allergic, inflammatory, and endocrine conditions.

Injectable forms (intramuscular and intravenous) are used when oral treatment is not possible, covering endocrine emergencies, shock, rheumatic disorders, and more. Eye-specific products treat different conditions: Dextenza (intracanalicular insert) treats eye inflammation and pain after eye surgery and itching from allergic conjunctivitis. Ozurdex (intravitreal implant) treats macular edema from retinal vein occlusion and diabetic macular edema, and non-infectious uveitis in the back of the eye. Dexycu (intraocular injection) treats inflammation after eye surgery. Maxidex (ophthalmic suspension) and dexamethasone sodium phosphate eye drops treat steroid-responsive inflammatory conditions of the eye. The ophthalmic/otic solution also treats steroid-responsive inflammation of the outer ear canal. A topical ointment (Seacall) is used for skin conditions including contact dermatitis, eczema, and neurodermatitis.

Most-Reported Side Effects for Dexamethasone

From FAERS, the FDA’s public side-effect reporting system (308,307 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 17,772 reports
Diarrhea 17,597 reports
Nausea 14,727 reports
Plasma cell myeloma 14,363 reports
Pneumonia 14,122 reports
See full Dexamethasone drug information
Keep checking

Other Drugs & Lactiplantibacillus Plantarum

Browse every other medication we’ve checked against Lactiplantibacillus Plantarum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
182Moderate
0Minor
2,647No known interaction
Moderate

182 interactions

Showing 60 of 182 moderate interactions — see all 182 on the Lactiplantibacillus Plantarum page.

No interaction 2,647 drugs checked — show the list
Evidence & sources

Lactiplantibacillus Plantarum References

The 12 references that drive our Lactiplantibacillus Plantarum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Ducrotté P, Sawant P, Jayanthi V. Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol 2012;18(30):4012-8.
  3. Krag A, Munkholm P, Israelsen H, von Ryberg B, Andersen KK, Bendtsen F. Profermin is efficacious in patients with active ulcerative colitis--a randomized controlled trial. Inflamm Bowel Dis. 2013;19(12):2584-92. PubMed
  4. Topcuoglu S, Gursoy T, Ovali F, Serce O, Karatekin G. A new risk factor for neonatal vancomycin-resistant Enterococcus colonisation: bacterial probiotics. J Matern Fetal Neonatal Med. 2015;28(12):1491-4. PubMed
  5. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  6. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  7. Axling U, Önning G, Martinsson Niskanen T, Larsson N, Hansson SR, Hulthén L. The effect of Lactiplantibacillus plantarum 299v together with a low dose of iron on iron status in healthy pregnant women: A randomized clinical trial. Acta Obstet Gynecol Scand
  8. Matsuura H, Kiura Y, Ito T, et al. Lactobacillus bacteremia: a diagnostic clue of rectal cancer. QJM. 2021;114(2):122-123. PubMed
  9. Lazou Ahrén I, Berggren A, Teixeira C, Martinsson Niskanen T, Larsson N. Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, doub
  10. Busch R, Gruenwald J, Dudek S. Randomized, double blind and placebo controlled study using a combination of two probiotic lactobacilli to alleviate symptoms and frequency of common cold. Food Nutr Sci 2013;4(11A):13-2. DOI
  11. Bengtsson J, Adlerberth I, Östblom A, Saksena P, Öresland T, Börjesson L. Effect of probiotics (Lactobacillus plantarum 299 plus Bifidobacterium Cure21) in patients with poor ileal pouch function: a randomised controlled trial. Scand J Gastroenterol 2016;
  12. Canaviri-Paz P, Oscarsson E, Kjellström A, Olsson H, Jois C, Håkansson Å. Effects on Microbiota Composition after Consumption of Quinoa Beverage Fermented by a Novel Xylose-Metabolizing L. plantarum Strain. Nutrients 2021;13(10):3318. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lactiplantibacillus Plantarum and Dexamethasone Together: Common Questions

Is it safe to take Lactiplantibacillus Plantarum with Dexamethasone?
We do not list a known interaction between Lactiplantibacillus Plantarum and Dexamethasone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Lactiplantibacillus Plantarum and Dexamethasone have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Lactiplantibacillus Plantarum and Dexamethasone used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Lactiplantibacillus Plantarum in each. That is a conversation for your prescriber, especially if Dexamethasone is being adjusted to a target.
How was the Lactiplantibacillus Plantarum and Dexamethasone combination checked?
Interactions in our licensed database are recorded against drug classes. Dexamethasone is filed under 8 classifications, and Lactiplantibacillus Plantarum has documented interactions with 1 drug class — none of Dexamethasone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Lactiplantibacillus Plantarum interact with any other medications?
Yes. Lactiplantibacillus Plantarum has 182 documented drug interactions in our database — Dexamethasone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Dexamethasone interact with any supplements?
Yes. Dexamethasone has documented interactions with 221 supplements in our database — Lactiplantibacillus Plantarum is not one of them. The Dexamethasone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Dexamethasone and Lactiplantibacillus Plantarum?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.