Drug & supplement interaction

Uzara + Methenamine Hippurate

Methenamine Hippurate brand names: Urex, Hiprex.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Uzara and Methenamine Hippurate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Uzara and Methenamine Hippurate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methenamine Hippurate and Uzara in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Uzara safety at a glance

Uzara overall Use caution It contains heart-active compounds and should only be used short-term and with professional guidance.
Pregnancy Avoid Safety is not established, so it is best avoided during pregnancy.
Breastfeeding Avoid There is not enough safety information, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methenamine Hippurate and Uzara? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Methenamine Hippurate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Methenamine Hippurate is filed under 2 classifications — antibiotic drugs, oral drugs. Uzara has documented interactions with 6 drug classes — the most serious being digoxin (lanoxin) (major), diuretic drugs (moderate) and macrolide antibiotics (moderate) — and none of Methenamine Hippurate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Uzara Does Interact With Other Medications

Uzara has 1 major, 132 moderate known drug interactions in our database — Methenamine Hippurate isn’t one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 132 No known interaction 2,697 (incl. Methenamine Hippurate)
Taking anything else?

Check Another of Your Medications Against Uzara

Covers the 2,830 medications we’ve checked against Uzara. Pick one to open its full report.

What to actually watch for

What Uzara Itself Has Been Linked To

This is not an interaction — nothing below involves Methenamine Hippurate. It is the side-effect record for Uzara on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Uzara, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • An irregular heartbeat / Raised blood pressure Worth acting on Additional detail

    “Orally, uzara can cause cardiotoxic effects, especially in patients with pre-existing cardiovascular disease. In one case report, a 68-year-old female with diabetes and hypertension was admitted to the emergency room with reduced left-ventricular function, pulmonary edema, and arrhythmia.”

    Uzara · Natural Medicines adverse-effect record, reported in arrhythmia.

    1 source cited
    1. 99461. Thürmann PA, Neff A, Fleisch J. Interference of Uzara glycosides in assays of digitalis glycosides. Int J Clin Pharmacol Ther. 2004;42(5):281-4. PubMed
  • Swelling Additional detail

    Recorded for Uzara in the same Natural Medicines adverse-effect record shown under An irregular heartbeat / Raised blood pressure above.

Everything above comes from the Natural Medicines adverse-effect record for Uzara — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Methenamine Hippurate’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Methenamine Hippurate column appears here.

Everything else you take

See Every Supplement That Interacts With Methenamine Hippurate

This page covers Uzara only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methenamine Hippurate page lists 44 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Bacillus Coagulans (moderate), Bacillus Subtilis (moderate), Bifidobacterium Animalis Subsp. Lactis (moderate) and Bifidobacterium Bifidum (moderate).

By severity: 1 major · 33 moderate · 10 minor.

From our pharmacist’s overview on the Methenamine Hippurate page

“Most people taking methenamine hippurate (Hiprex, Urex) use it daily to prevent repeat urinary tract infections, and many also take probiotics, which is where the bulk of this 44-ingredient list sits. Even so, the page deserves real vigilance, because one entry is rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Methenamine Hippurate interaction page

How much people look this up

Where Uzara and Methenamine Hippurate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Uzara
Steady interest

#872 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methenamine Hippurate
Steady interest

#2,023 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Uzara reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Uzara and Methenamine Hippurate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Uzara

What is Uzara?

  • Diarrhea
  • Stomach cramps
  • Menstrual cramps (dysmenorrhea)
  • Headaches
  • Digestive upset

Uzara is a traditional African root remedy used mainly for diarrhea and stomach cramps. Because it contains cardiac glycosides that can affect the heart, it should be used cautiously and for short periods only. Talk to a pharmacist or doctor before using it, especially if you have heart problems, are pregnant, or take heart medications.

Xysmalobium undulatum · Apocynaceae · Dried root · Liquid extract, tincture, tablets, drops

An interaction check asks whether these two react with each other — it does not ask whether Uzara is a good idea for someone in your situation. Here is what our Uzara record says about it on its own.

Uzara: dosing

There is no well-established standard dose for Uzara, and products vary in strength. The right amount depends on the specific preparation, such as drops, tincture, or tablets.The safest approach is to follow the directions on the product label and use it only for short periods. Do not exceed the recommended amount, since higher doses raise the risk of heart-related side effects.

From our Uzara monograph — the full record covers uses, side effects and every documented interaction.

Read the full Uzara monograph & all interactions
Medication

About Methenamine

What Is Methenamine Used For?

Brand names: Urex, Hiprex

Methenamine is used to suppress or prevent frequently recurring urinary tract infections (UTIs), including pyelonephritis (kidney infection) and cystitis (bladder infection). It is intended for long-term or ongoing use after another antibiotic has already cleared the active infection — not as a first treatment for a new, acute infection.

Methenamine Mandelate (available as an oral solution and tablet) is also indicated for infected residual urine that can occur with certain neurologic diseases. It is not appropriate as the sole treatment when an infection is causing systemic symptoms like chills and fever.

Most-Reported Side Effects for Methenamine Hippurate

From FAERS, the FDA’s public side-effect reporting system (1,210 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Urinary tract infection 163 reports
Diarrhea 81 reports
Nausea 80 reports
Fall 74 reports
Fatigue 74 reports
See full Methenamine drug information
Keep checking

Other Drugs & Uzara

Browse every other medication we’ve checked against Uzara — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
132Moderate
0Minor
2,696No known interaction
1 Major 132 Moderate 2,696 No interaction
Major

1 interaction

Moderate

132 interactions

Showing 60 of 132 moderate interactions — see all 132 on the Uzara page.

No interaction 2,696 drugs checked — show the list

We also checked Uzara against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,696 medications checked with no known interaction — see the full Uzara list.

See the full Uzara interactions page
See every supplement checked against Methenamine Hippurate, ranked by severity
Evidence & sources

Uzara References

The 7 references that drive our Uzara monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  5. Abd-El-Maeboud KH, Kortam MA, Ali MS, Ibrahim MI, Mohamed RM. A preliminary pilot randomized crossover study of uzara (Xysmalobium undulatum) versus ibuprofen in the treatment of primary dysmenorrhea. PLoS One. 2014;9(8):e104473. PubMed
  6. Schmiedl S, Ritter A, Szymanski J, et al. Cardiovascular effects, pharmacokinetics and cross-reactivity in digitalis glycoside immunoassays of an antidiarrheal uzara root extract. Int J Clin Pharmacol Ther. 2012;50(10):729-40. PubMed
  7. Thürmann PA, Neff A, Fleisch J. Interference of Uzara glycosides in assays of digitalis glycosides. Int J Clin Pharmacol Ther. 2004;42(5):281-4. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Uzara and Methenamine Hippurate Together: Common Questions

Is it safe to take Uzara with Methenamine Hippurate?
We do not list a known interaction between Uzara and Methenamine Hippurate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Uzara and Methenamine Hippurate combination checked?
Interactions in our licensed database are recorded against drug classes. Methenamine Hippurate is filed under 2 classifications, and Uzara has documented interactions with 6 drug classes — none of Methenamine Hippurate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Uzara interact with any other medications?
Yes. Uzara has 133 documented drug interactions in our database — Methenamine Hippurate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Methenamine Hippurate interact with any supplements?
Yes. Methenamine Hippurate has documented interactions with 44 supplements in our database — Uzara is not one of them. The Methenamine Hippurate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Uzara monograph Uses, safety profile, and every drug interaction in one place Methenamine drug information The full plain-English guide to this medication Methenamine Hippurate supplement interactions Every supplement checked against Methenamine Hippurate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Methenamine Hippurate and Uzara?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.