Drug & supplement interaction

Wahoo + Phenazopyridine

Phenazopyridine brand names: Pyridium, Azo-Standard, Phenazo, UTI Relief.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Wahoo and Phenazopyridine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Wahoo and Phenazopyridine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Phenazopyridine and Wahoo in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wahoo safety at a glance

Wahoo overall Avoid Wahoo is considered poisonous and can cause serious, even life-threatening effects.
Pregnancy Likely Unsafe When used orally. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Phenazopyridine and Wahoo? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Phenazopyridine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Phenazopyridine is filed under a single classification — oral drugs. Wahoo has documented interactions with 6 drug classes — the most serious being digoxin (lanoxin) (major), diuretic drugs (moderate) and macrolide antibiotics (moderate) — and none of Phenazopyridine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Wahoo Does Interact With Other Medications

Wahoo has 1 major, 132 moderate known drug interactions in our database — Phenazopyridine isn’t one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 132 No known interaction 2,697 (incl. Phenazopyridine)
Taking anything else?

Check Another of Your Medications Against Wahoo

Covers the 2,830 medications we’ve checked against Wahoo. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Wahoo and Phenazopyridine May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea Additional detail

    Wahoo

    “Wahoo is considered poisonous (17). Several hours after ingesting wahoo seeds, people experience severe upset stomach, sometimes with bloody diarrhea, fever, shortness of breath, circulatory problems, signs of collapse, stupor increasing to unconsciousness, alternating with motor restlessness, severe tonic-clonic spasms with locked jaw muscles and coma.”

    Wahoo · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 17. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.

    Phenazopyridine

    Listed in the ADVERSE REACTIONS section of the FDA label for Phenazopyridine. Read the label on DailyMed ›

Reported for Wahoo but not commonly for Phenazopyridine: shortness of breath, stomach upset, anxiety or restlessness and fever.

Effects for Phenazopyridine come from the ADVERSE REACTIONS section of its FDA label; effects for Wahoo come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Wahoo in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Phenazopyridine

This page covers Wahoo only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Phenazopyridine page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Phenazopyridine page

“Phenazopyridine (Pyridium, Azo-Standard) only eases urinary burning while enough of it reaches your bladder, and every one of the 17 supplements on this list can interfere with that by changing how the drug is absorbed. Activated charcoal is the standout, the single major-rated entry, because it can bind the drug in the gut and sharply…”

Reviewed by 2 · Jul 18, 2026

Open the Phenazopyridine interaction page

One more smart check

Taking Wahoo as Part of a Dietary Supplement Product? Check It for Interactions

We hold 9 real supplement products containing Wahoo, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wahoo. Even though Wahoo itself has no known interaction with Phenazopyridine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Wahoo and Phenazopyridine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wahoo
Top half

#609 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Phenazopyridine
Steady interest

#1,744 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wahoo reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Wahoo and Phenazopyridine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Wahoo

What is Wahoo?

Wahoo
  • Constipation (traditional laxative)
  • Digestive complaints
  • Liver and gallbladder support (folk use)
  • Fluid retention (traditional diuretic)
  • Skin irritations (folk use)

Wahoo is a North American shrub historically used as a laxative and 'liver tonic,' but it is a poisonous plant with no proven benefit and a real risk of serious harm. Because it contains heart-affecting and other toxic compounds, we do not recommend using it, and there is no established safe dose.

Euonymus atropurpureus · Celastraceae · Dried root bark and stem bark (historically) · Historically tinctures, extracts, and powdered bark; rarely available today

An interaction check asks whether these two react with each other — it does not ask whether Wahoo is a good idea for someone in your situation. Here is what our Wahoo record says about it on its own.

Wahoo: dosing

There is no established safe or effective dose of wahoo, and we do not recommend using it. In most cases the safest choice is to avoid it entirely and use a better-studied, safer option instead.

From our Wahoo monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wahoo monograph & all interactions
Medication

About Phenazopyridine

What Is Phenazopyridine Used For?

Brand names: Pyridium, Azo-Standard, Phenazo, UTI Relief

Phenazopyridine treats the symptoms of lower urinary tract irritation — pain, burning, urgency, and frequent urination. These symptoms can result from a urinary tract infection (UTI), trauma, surgery, endoscopic procedures, or the passage of catheters or other instruments.

It is a pain reliever only — it does not treat the underlying infection or cause. When used alongside an antibiotic for a UTI, treatment should not exceed 2 days, and it should be stopped once symptoms are controlled. It must not replace antibiotics or other needed treatment.

See full Phenazopyridine drug information
Keep checking

Other Drugs & Wahoo

Browse every other medication we’ve checked against Wahoo — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
132Moderate
0Minor
2,696No known interaction
1 Major 132 Moderate 2,696 No interaction
Major

1 interaction

Moderate

132 interactions

Showing 60 of 132 moderate interactions — see all 132 on the Wahoo page.

No interaction 2,696 drugs checked — show the list

We also checked Wahoo against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,696 medications checked with no known interaction — see the full Wahoo list.

See the full Wahoo interactions page
See every supplement checked against Phenazopyridine, ranked by severity
Evidence & sources

Wahoo References

The 4 references that drive our Wahoo monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wahoo and Phenazopyridine Together: Common Questions

Is it safe to take Wahoo with Phenazopyridine?
We do not list a known interaction between Wahoo and Phenazopyridine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Wahoo and Phenazopyridine have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Wahoo and Phenazopyridine combination checked?
Interactions in our licensed database are recorded against drug classes. Phenazopyridine is filed under 1 classification, and Wahoo has documented interactions with 6 drug classes — none of Phenazopyridine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Wahoo interact with any other medications?
Yes. Wahoo has 133 documented drug interactions in our database — Phenazopyridine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Phenazopyridine interact with any supplements?
Yes. Phenazopyridine has documented interactions with 17 supplements in our database — Wahoo is not one of them. The Phenazopyridine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wahoo monograph Uses, safety profile, and every drug interaction in one place Phenazopyridine drug information The full plain-English guide to this medication Phenazopyridine supplement interactions Every supplement checked against Phenazopyridine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Phenazopyridine and Wahoo?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.