Drug & supplement interaction

Wahoo + Osimertinib Mesylate

Osimertinib Mesylate brand name: Tagrisso.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Wahoo and Osimertinib Mesylate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Wahoo and Osimertinib Mesylate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Osimertinib Mesylate and Wahoo in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wahoo safety at a glance

Wahoo overall Avoid Wahoo is considered poisonous and can cause serious, even life-threatening effects.
Pregnancy Likely Unsafe When used orally. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Osimertinib Mesylate and Wahoo? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Osimertinib Mesylate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Osimertinib Mesylate is filed under 6 classifications — including cytochrome p450 1a2 (cyp1a2) inhibitors, qt interval-prolonging drugs, cytochrome p450 3a4 (cyp3a4) inhibitors. Wahoo has documented interactions with 6 drug classes — the most serious being digoxin (lanoxin) (major), diuretic drugs (moderate) and macrolide antibiotics (moderate) — and none of Osimertinib Mesylate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Wahoo Does Interact With Other Medications

Wahoo has 1 major, 132 moderate known drug interactions in our database — Osimertinib Mesylate isn’t one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 132 No known interaction 2,697 (incl. Osimertinib Mesylate)
Taking anything else?

Check Another of Your Medications Against Wahoo

Covers the 2,830 medications we’ve checked against Wahoo. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Wahoo and Osimertinib Mesylate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach upset / Diarrhea Additional detail

    Wahoo

    “Wahoo is considered poisonous (17). Several hours after ingesting wahoo seeds, people experience severe upset stomach, sometimes with bloody diarrhea, fever, shortness of breath, circulatory problems, signs of collapse, stupor increasing to unconsciousness, alternating with motor restlessness, severe tonic-clonic spasms with locked jaw muscles and coma.”

    Wahoo · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 17. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.

    Osimertinib Mesylate

    Listed in the ADVERSE REACTIONS section of the FDA label for Osimertinib Mesylate. Read the label on DailyMed ›

Reported for Wahoo but not commonly for Osimertinib Mesylate: shortness of breath, anxiety or restlessness and fever.

Effects for Osimertinib Mesylate come from the ADVERSE REACTIONS section of its FDA label; effects for Wahoo come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Wahoo in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Wahoo or Osimertinib Mesylate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Wahoo or Osimertinib Mesylate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Osimertinib Mesylate

This page covers Wahoo only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Osimertinib Mesylate page lists 164 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 117 moderate · 39 minor.

From our pharmacist’s overview on the Osimertinib Mesylate page

“Osimertinib (Tagrisso) treats EGFR-mutated lung cancer, and this is a list to read carefully before you add anything from the supplement aisle. Of the 164 ingredients on file, most can change how much drug reaches your blood, chiefly through the CYP3A4 enzyme that clears it.”

Reviewed by 2 · Jul 18, 2026

Open the Osimertinib Mesylate interaction page

One more smart check

Taking Wahoo as Part of a Dietary Supplement Product? Check It for Interactions

We hold 9 real supplement products containing Wahoo, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wahoo. Even though Wahoo itself has no known interaction with Osimertinib Mesylate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Wahoo and Osimertinib Mesylate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wahoo
Top half

#552 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Osimertinib Mesylate
Top half

#1,309 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wahoo reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Wahoo and Osimertinib Mesylate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Wahoo

What is Wahoo?

Wahoo
  • Constipation (traditional laxative)
  • Digestive complaints
  • Liver and gallbladder support (folk use)
  • Fluid retention (traditional diuretic)
  • Skin irritations (folk use)

Wahoo is a North American shrub historically used as a laxative and 'liver tonic,' but it is a poisonous plant with no proven benefit and a real risk of serious harm. Because it contains heart-affecting and other toxic compounds, we do not recommend using it, and there is no established safe dose.

Euonymus atropurpureus · Celastraceae · Dried root bark and stem bark (historically) · Historically tinctures, extracts, and powdered bark; rarely available today

An interaction check asks whether these two react with each other — it does not ask whether Wahoo is a good idea for someone in your situation. Here is what our Wahoo record says about it on its own.

Wahoo: dosing

There is no established safe or effective dose of wahoo, and we do not recommend using it. In most cases the safest choice is to avoid it entirely and use a better-studied, safer option instead.

From our Wahoo monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wahoo monograph & all interactions
Medication

About Osimertinib

What Is Osimertinib Used For?

Brand name: Tagrisso

Tagrisso is used to treat adults with non-small cell lung cancer (NSCLC) whose tumors have specific EGFR mutations — either an exon 19 deletion or an exon 21 L858R mutation — confirmed by an FDA-approved test. It is used in several settings: after surgery to reduce the risk of cancer returning (adjuvant therapy), for locally advanced stage III NSCLC that has not progressed after chemoradiation, and as a first-line treatment for locally advanced or metastatic NSCLC (including in combination with pemetrexed and platinum-based chemotherapy).

Tagrisso is also approved for adults with metastatic NSCLC that carries a specific resistance mutation called T790M, when the cancer has stopped responding to another EGFR-targeted therapy.

See full Osimertinib drug information
Keep checking

Other Drugs & Wahoo

Browse every other medication we’ve checked against Wahoo — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
132Moderate
0Minor
2,696No known interaction
1 Major 132 Moderate 2,696 No interaction
Major

1 interaction

Moderate

132 interactions

Showing 60 of 132 moderate interactions — see all 132 on the Wahoo page.

No interaction 2,696 drugs checked — show the list

We also checked Wahoo against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,696 medications checked with no known interaction — see the full Wahoo list.

See the full Wahoo interactions page
See every supplement checked against Osimertinib Mesylate, ranked by severity
Evidence & sources

Wahoo References

The 4 references that drive our Wahoo monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wahoo and Osimertinib Mesylate Together: Common Questions

Is it safe to take Wahoo with Osimertinib Mesylate?
We do not list a known interaction between Wahoo and Osimertinib Mesylate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Wahoo and Osimertinib Mesylate have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Wahoo and Osimertinib Mesylate combination checked?
Interactions in our licensed database are recorded against drug classes. Osimertinib Mesylate is filed under 6 classifications, and Wahoo has documented interactions with 6 drug classes — none of Osimertinib Mesylate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Wahoo interact with any other medications?
Yes. Wahoo has 133 documented drug interactions in our database — Osimertinib Mesylate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Osimertinib Mesylate interact with any supplements?
Yes. Osimertinib Mesylate has documented interactions with 164 supplements in our database — Wahoo is not one of them. The Osimertinib Mesylate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wahoo monograph Uses, safety profile, and every drug interaction in one place Osimertinib drug information The full plain-English guide to this medication Osimertinib Mesylate supplement interactions Every supplement checked against Osimertinib Mesylate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Osimertinib Mesylate and Wahoo?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.