Drug & supplement interaction

Corn Silk + Ibuprofen

Ibuprofen brand names: Motrin, Children's Motrin, Advil, Children's Advil, Fenbid Forte Gel, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Corn Silk and Ibuprofen in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Corn Silk and Ibuprofen

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ibuprofen and Corn Silk in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Corn Silk safety at a glance

Corn Silk overall Use caution Generally well tolerated for short-term use, but human safety data are limited.
Pregnancy Avoid Not enough reliable safety data, so it is best avoided during pregnancy.
Breastfeeding Possibly Safe When consumed in food amounts. Insufficient reliable information available when used as medicine; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ibuprofen and Corn Silk? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ibuprofen

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ibuprofen is filed under 10 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), cytochrome p450 2c9 (cyp2c9) substrates, anticoagulant/antiplatelet drugs. Corn Silk has documented interactions with 5 drug classes — the most serious being antidiabetes drugs (moderate), antihypertensive drugs (moderate) and corticosteroids (moderate) — and none of Ibuprofen’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Corn Silk Does Interact With Other Medications

Corn Silk has 290 moderate known drug interactions in our database — Ibuprofen isn’t one of them. If you take anything else, check it against the full list below.

Moderate 290 No known interaction 2,540 (incl. Ibuprofen)
Taking anything else?

Check Another of Your Medications Against Corn Silk

Covers the 2,830 medications we’ve checked against Corn Silk. Pick one to open its full report.

What to actually watch for

What Corn Silk Itself Has Been Linked To

This is not an interaction — nothing below involves Ibuprofen. It is the side-effect record for Corn Silk on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Corn Silk, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • Low sodium Worth acting on Additional detail

    “Orally, adverse effects to corn silk seem to be rare; however, a thorough safety evaluation has not been conducted.

    Most Common Adverse Effects:

    Orally: Hypokalemia, hyponatremia.”

    Corn Silk · Natural Medicines adverse-effect record, reported in hypokalemia.

  • Low potassium Worth acting on Additional detail

    “Orally, corn silk has been reported to cause hypokalemia with prolonged use (4).”

    Corn Silk · Natural Medicines adverse-effect record, reported in hypokalemia.

    1 source cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  • Hives Worth acting on Additional detail

    “Topically, corn silk can cause dermatitis and urticaria (4).”

    Corn Silk · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  • A skin rash Additional detail

    Recorded for Corn Silk in the same Natural Medicines adverse-effect record shown under Hives above.

Everything above comes from the Natural Medicines adverse-effect record for Corn Silk — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Ibuprofen’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Ibuprofen column appears here.

Special populations

Corn Silk in Pregnancy & Breastfeeding

Lactation Possibly Safe

When consumed in food amounts. Insufficient reliable information available when used as medicine; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Corn Silk or Ibuprofen

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Corn Silk or Ibuprofen, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ibuprofen

This page covers Corn Silk only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ibuprofen page lists 286 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 243 moderate · 36 minor.

From our pharmacist’s overview on the Ibuprofen page

“Most people treat ibuprofen (Advil, Motrin) as an everyday pain reliever, which is exactly why this list of 286 interacting supplements deserves real attention rather than a shrug. The dominant pattern by far is bleeding: 202 of these ingredients can add to the bleeding and stomach irritation ibuprofen already causes, and the seven maj…”

Reviewed by 2 · Jul 18, 2026

Open the Ibuprofen interaction page

One more smart check

Taking Corn Silk as Part of a Dietary Supplement Product? Check It for Interactions

We hold 58 real supplement products containing Corn Silk, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Corn Silk. Even though Corn Silk itself has no known interaction with Ibuprofen, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Corn Silk and Ibuprofen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Corn Silk
Top half

#567 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ibuprofen
Top 1%

#19 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Corn Silk reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Corn Silk and Ibuprofen records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Corn Silk

What is Corn Silk?

Corn Silk
  • Urinary tract and bladder problems
  • Mild fluid retention (diuretic)
  • Kidney and prostate concerns
  • Bedwetting in children
  • Soothing urinary irritation

Corn silk is a traditional herbal remedy taken as a tea or extract, mostly for urinary and mild fluid-related complaints. High-quality human evidence for these uses is limited, so it should not replace proven treatments. It is generally considered low-risk for short-term use in healthy adults, but talk with your pharmacist or doctor before trying it.

Zea mays · Poaceae · Stigmas and styles (the silky strands) of the corn ear · Tea, dried herb, liquid extract/tincture, capsules

An interaction check asks whether these two react with each other — it does not ask whether Corn Silk is a good idea for someone in your situation. Here is what our Corn Silk record says about it on its own.

Corn Silk: dosing

There is no official, standardized dose for corn silk. It has traditionally been taken as a tea made by steeping dried corn silk in hot water, or as a liquid extract or capsule.Because product strengths vary widely, the best advice is to follow the directions on the product label and not exceed them.

From our Corn Silk monograph — the full record covers uses, side effects and every documented interaction.

Read the full Corn Silk monograph & all interactions
Medication

About Ibuprofen

What Is Ibuprofen Used For?

Brand names: Motrin, Children's Motrin, Advil, Children's Advil, Fenbid Forte Gel, Ibugel Forte, Arthrofen, Ebufac, Rimafen, Calprofen, Fenpaed, Galprofen, Nurofen for Children, Orbifen for Children, Brufen, Brufen Retard, Fenbid, Tab-Profen, Ibuprofen, Calodor

Oral ibuprofen products (tablets, coated tablets, and liquid-filled capsules) are used to temporarily relieve minor aches and pains from headache, backache, toothache, muscular aches, menstrual cramps, minor arthritis pain, and the common cold, and to temporarily reduce fever. The oral prescription tablet (Ibu) is also indicated for the signs and symptoms of rheumatoid arthritis and osteoarthritis, mild to moderate pain, and primary dysmenorrhea (painful periods).

Caldolor, an intravenous (IV) form, is approved for adults and children 3 months and older to manage mild to moderate pain, to manage moderate to severe pain alongside opioid pain medicines, and to reduce fever. A separate intravenous solution, Ibuprofen Lysine, is used specifically in premature infants to close a patent ductus arteriosus (PDA) — an abnormal blood vessel connection near the heart — when standard medical management has not worked.

Most-Reported Side Effects for Ibuprofen

From FAERS, the FDA’s public side-effect reporting system (283,500 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 18,755 reports
Nausea 18,290 reports
Headache 16,566 reports
Arthralgia 13,469 reports
Dyspnea 13,139 reports
See full Ibuprofen drug information
Keep checking

Other Drugs & Corn Silk

Browse every other medication we’ve checked against Corn Silk — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
290Moderate
0Minor
2,539No known interaction
290 Moderate 2,539 No interaction
Moderate

290 interactions

Showing 60 of 290 moderate interactions — see all 290 on the Corn Silk page.

No interaction 2,539 drugs checked — show the list

We also checked Corn Silk against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,539 medications checked with no known interaction — see the full Corn Silk list.

See the full Corn Silk interactions page
See every supplement checked against Ibuprofen, ranked by severity
Evidence & sources

Corn Silk References

The 4 references that drive our Corn Silk monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. George GO, Idu FK. Corn silk aqueous extracts and intraocular pressure of systemic and non-systemic hypertensive subjects. Clin Exp Optom. 2015 Mar;98(2):138-49. PubMed
  4. Sheng L, Chen Q, Di L, Li N. Evaluation of anti-diabetic potential of corn silk in high-fat diet/streptozotocin- induced type 2 diabetes mice model. Endocr Metab Immune Disord Drug Targets. 2020. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Corn Silk and Ibuprofen Together: Common Questions

Is it safe to take Corn Silk with Ibuprofen?
We do not list a known interaction between Corn Silk and Ibuprofen. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Corn Silk and Ibuprofen combination checked?
Interactions in our licensed database are recorded against drug classes. Ibuprofen is filed under 10 classifications, and Corn Silk has documented interactions with 5 drug classes — none of Ibuprofen's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Corn Silk interact with any other medications?
Yes. Corn Silk has 290 documented drug interactions in our database — Ibuprofen is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ibuprofen interact with any supplements?
Yes. Ibuprofen has documented interactions with 286 supplements in our database — Corn Silk is not one of them. The Ibuprofen interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Corn Silk monograph Uses, safety profile, and every drug interaction in one place Ibuprofen drug information The full plain-English guide to this medication Ibuprofen supplement interactions Every supplement checked against Ibuprofen, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ibuprofen and Corn Silk?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.