Drug & supplement interaction

Corn Silk + Bupropion

Bupropion brand names: Wellbutrin, Wellbutrin SR, Zyban, Wellbutrin XL, Aplenzin, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Corn Silk and Bupropion in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Corn Silk and Bupropion

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Bupropion and Corn Silk in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Corn Silk safety at a glance

Corn Silk overall Use caution Generally well tolerated for short-term use, but human safety data are limited.
Pregnancy Avoid Not enough reliable safety data, so it is best avoided during pregnancy.
Breastfeeding Possibly Safe When consumed in food amounts. Insufficient reliable information available when used as medicine; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Bupropion and Corn Silk? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Bupropion

Interactions in our licensed database are recorded against drug classes, not just single drug names. Bupropion is filed under 6 classifications — including antidepressant drugs, cytochrome p450 2b6 (cyp2b6) substrates, cytochrome p450 2d6 (cyp2d6) inhibitors. Corn Silk has documented interactions with 5 drug classes — the most serious being antidiabetes drugs (moderate), antihypertensive drugs (moderate) and corticosteroids (moderate) — and none of Bupropion’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Corn Silk Does Interact With Other Medications

Corn Silk has 290 moderate known drug interactions in our database — Bupropion isn’t one of them. If you take anything else, check it against the full list below.

Moderate 290 No known interaction 2,540 (incl. Bupropion)
Taking anything else?

Check Another of Your Medications Against Corn Silk

Covers the 2,830 medications we’ve checked against Corn Silk. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Corn Silk and Bupropion May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Hives Worth acting on Additional detail

    Corn Silk

    “Topically, corn silk can cause dermatitis and urticaria (4).”

    Corn Silk · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.

    Bupropion

    Listed in the ADVERSE REACTIONS section of the FDA label for Bupropion. Read the label on DailyMed ›

  • A skin rash Additional detail

    Corn Silk

    Recorded for Corn Silk in the same Natural Medicines adverse-effect record shown under Hives above.

    Bupropion

    Listed in the ADVERSE REACTIONS section of the FDA label for Bupropion. Read the label on DailyMed ›

Reported for Corn Silk but not commonly for Bupropion: low sodium and low potassium.

Effects for Bupropion come from the ADVERSE REACTIONS section of its FDA label; effects for Corn Silk come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 152,137 voluntary FDA FAERS reports for Bupropion that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Corn Silk in Pregnancy & Breastfeeding

Lactation Possibly Safe

When consumed in food amounts. Insufficient reliable information available when used as medicine; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Bupropion Is Prescribed For, and What Corn Silk Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Bupropion is a prescription medicine with approved uses on its FDA label. Corn Silk is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Bupropion is prescribed for: Bupropion is FDA-approved to treat major depressive disorder (MDD) — a form of clinical depression. Extended-release formulations (XL and hydrobromide versions, including Aplenzin) are also approved for the prevention of seasonal affective disorder (SAD), the pattern of depression that tends to arrive in autumn and winter. Not all formulations share every indication. Aplenzin (bupropion hydrobromide extended-release) and bupropion hydrochloride extended-release tablets (XL) are indicated for both MDD and SAD.

Read the rest of what Bupropion is prescribed for

Bupropion hydrochloride extended-release tablets (SR) and bupropion hydrochloride immediate-release tablets are indicated for MDD only.

Corn Silk has been studied for:

  • Depression studied, not established Corn Silk has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Corn Silk for depression

    Although there has been interest in using oral corn silk for depression, there is insufficient reliable information about the clinical effects of corn silk for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Bupropion on your own; if you are taking Corn Silk for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Corn Silk or Bupropion

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Corn Silk or Bupropion, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Bupropion

This page covers Corn Silk only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bupropion page lists 46 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), African Wild Potato (moderate), Artichoke (moderate) and Astaxanthin (moderate).

By severity: 1 major · 33 moderate · 12 minor.

From our pharmacist’s overview on the Bupropion page

“Bupropion (Wellbutrin, Zyban) deserves genuine care around supplements, and the entry to understand first is activated charcoal, the only major-rated interaction on this list. Charcoal and similar bulk products can soak up the drug in the gut and blunt its effect, so space them well apart from your dose.”

Reviewed by 2 · Jul 18, 2026

Open the Bupropion interaction page

One more smart check

Taking Corn Silk as Part of a Dietary Supplement Product? Check It for Interactions

We hold 58 real supplement products containing Corn Silk, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Corn Silk. Even though Corn Silk itself has no known interaction with Bupropion, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Corn Silk and Bupropion Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Corn Silk
Top half

#575 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bupropion
Top 1%

#23 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Corn Silk reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Corn Silk and Bupropion records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Corn Silk

What is Corn Silk?

Corn Silk
  • Urinary tract and bladder problems
  • Mild fluid retention (diuretic)
  • Kidney and prostate concerns
  • Bedwetting in children
  • Soothing urinary irritation

Corn silk is a traditional herbal remedy taken as a tea or extract, mostly for urinary and mild fluid-related complaints. High-quality human evidence for these uses is limited, so it should not replace proven treatments. It is generally considered low-risk for short-term use in healthy adults, but talk with your pharmacist or doctor before trying it.

Zea mays · Poaceae · Stigmas and styles (the silky strands) of the corn ear · Tea, dried herb, liquid extract/tincture, capsules

An interaction check asks whether these two react with each other — it does not ask whether Corn Silk is a good idea for someone in your situation. Here is what our Corn Silk record says about it on its own.

Corn Silk: dosing

There is no official, standardized dose for corn silk. It has traditionally been taken as a tea made by steeping dried corn silk in hot water, or as a liquid extract or capsule.Because product strengths vary widely, the best advice is to follow the directions on the product label and not exceed them.

From our Corn Silk monograph — the full record covers uses, side effects and every documented interaction.

Read the full Corn Silk monograph & all interactions
Medication

About Bupropion

What Is Bupropion Used For?

Brand names: Wellbutrin, Wellbutrin SR, Zyban, Wellbutrin XL, Aplenzin, Forfivo XL

Bupropion is FDA-approved to treat major depressive disorder (MDD) — a form of clinical depression. Extended-release formulations (XL and hydrobromide versions, including Aplenzin) are also approved for the prevention of seasonal affective disorder (SAD), the pattern of depression that tends to arrive in autumn and winter.

Not all formulations share every indication. Aplenzin (bupropion hydrobromide extended-release) and bupropion hydrochloride extended-release tablets (XL) are indicated for both MDD and SAD. Bupropion hydrochloride extended-release tablets (SR) and bupropion hydrochloride immediate-release tablets are indicated for MDD only.

Most-Reported Side Effects for Bupropion

From FAERS, the FDA’s public side-effect reporting system (152,137 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 11,909 reports
Fatigue 10,076 reports
Headache 10,053 reports
Depression 8,639 reports
Dizziness 7,786 reports
See full Bupropion drug information
Keep checking

Other Drugs & Corn Silk

Browse every other medication we’ve checked against Corn Silk — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
290Moderate
0Minor
2,539No known interaction
290 Moderate 2,539 No interaction
Moderate

290 interactions

Showing 60 of 290 moderate interactions — see all 290 on the Corn Silk page.

No interaction 2,539 drugs checked — show the list

We also checked Corn Silk against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,539 medications checked with no known interaction — see the full Corn Silk list.

See the full Corn Silk interactions page
See every supplement checked against Bupropion, ranked by severity
Evidence & sources

Corn Silk References

The 4 references that drive our Corn Silk monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. George GO, Idu FK. Corn silk aqueous extracts and intraocular pressure of systemic and non-systemic hypertensive subjects. Clin Exp Optom. 2015 Mar;98(2):138-49. PubMed
  4. Sheng L, Chen Q, Di L, Li N. Evaluation of anti-diabetic potential of corn silk in high-fat diet/streptozotocin- induced type 2 diabetes mice model. Endocr Metab Immune Disord Drug Targets. 2020. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Corn Silk and Bupropion Together: Common Questions

Is it safe to take Corn Silk with Bupropion?
We do not list a known interaction between Corn Silk and Bupropion. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Corn Silk and Bupropion have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Corn Silk and Bupropion used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Corn Silk in each. That is a conversation for your prescriber, especially if Bupropion is being adjusted to a target.
How was the Corn Silk and Bupropion combination checked?
Interactions in our licensed database are recorded against drug classes. Bupropion is filed under 6 classifications, and Corn Silk has documented interactions with 5 drug classes — none of Bupropion's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Corn Silk interact with any other medications?
Yes. Corn Silk has 290 documented drug interactions in our database — Bupropion is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Bupropion interact with any supplements?
Yes. Bupropion has documented interactions with 46 supplements in our database — Corn Silk is not one of them. The Bupropion interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Corn Silk monograph Uses, safety profile, and every drug interaction in one place Bupropion drug information The full plain-English guide to this medication Bupropion supplement interactions Every supplement checked against Bupropion, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Bupropion and Corn Silk?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.