Bupropion

117 interactions 4 explained in plain English

Also sold as: Aplenzin Aplenzin® Budeprion® SR Budeprion® XL Buproban® Forfivo Forfivo® XL Wellbutrin Wellbutrin® Wellbutrin® SR Wellbutrin® XL Zyban®

About Bupropion

Bupropion is an antidepressant used to treat depression, seasonal affective disorder, and to help people quit smoking. Read the full Bupropion drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Nebivolol Dopamine Famotidine Acyclovir Penicillin V Potassium

1 Contraindicated 114 Major 2 Moderate

All (117) Contraindicated (1) Major (114) Moderate (2)

Contraindicated

Bupropion Linezolid Injection Zyvox Increased risk of hypertensive reactions Details

Major

Bupropion Amitriptyline Elavil Explained Increased exposure of CYP2D6 substrates and an increased risk of seizure Details Bupropion Sertraline Explained Increased sertraline exposure, an increased risk of seizure, severe head injury, arteriovenous malformations, CNS tumor or CNS inf... Details Bupropion Buprenorphine Belbuca Explained Increased risk of seizures Details Bupropion Acyclovir Avaclyr Increased risk of seizures Details Bupropion Acyclovir Injection Avaclyr Increased risk of seizures Details Bupropion Acyclovir Ophthalmic Avaclyr Increased risk of seizures Details Bupropion Acyclovir Topical Zovirax Increased risk of seizures Details Bupropion Alcaftadine Ophthalmic Lastacaft Increased risk of seizures Details Bupropion Ampicillin Amcill® Increased risk of seizures Details Bupropion Ampicillin Injection Omnipen-N® Increased risk of seizures Details Bupropion Aripiprazole Injection Abilify Increased ARIPiprazole exposure Details Bupropion Atovaquone Mepron Increased risk of seizures Details Bupropion Aztreonam Injection Azactam Increased risk of seizures Details Bupropion Aclidinium Oral Inhalation Tudorza Increased risk of seizures Details Bupropion Amphotericin B Injection Abelcet Increased risk of seizures Details Bupropion Azelastine Nasal Spray Astelin® Nasal Spray Increased risk of seizures Details Bupropion Azelastine Ophthalmic Optivar® Increased risk of seizures Details Bupropion Atropine Ophthalmic Atropine Care 1% Increased risk of seizures Details Bupropion Besifloxacin Ophthalmic Besivance Increased risk of seizures Details Bupropion Bepotastine Ophthalmic Bepreve Increased risk of seizures Details Bupropion Brexpiprazole Rexulti Increased brexpiprazole exposure Details Bupropion Budesonide Entocort Lowering of the seizure threshold Details Bupropion Budesonide Nasal Spray Rhinocort Lowering of the seizure threshold Details Bupropion Budesonide Oral Inhalation Pulmicort Lowering of the seizure threshold Details Bupropion Busulfan Injection Busulfex Increased risk of seizures Details Bupropion Butorphanol Injection Butorphic Increased risk of seizures Details Bupropion Butorphanol Nasal Spray Stadol® NS Increased risk of seizures Details Bupropion Chlorambucil Leukeran Increased risk of seizures Details Bupropion Chloroquine Aralen® Increased risk of seizures Details Bupropion Clopidogrel Plavix Increased buPROPion exposure, reduced hydroxybuPROPion exposure Details Bupropion Cyclopentolate Ophthalmic Akpentolate® Increased risk of seizures Details Bupropion Cyclosporine Injection Atopica Increased risk of seizures Details Bupropion Cyclosporine Ophthalmic Cequa Increased risk of seizures Details Bupropion Dalfampridine Ampyra Increased risk of seizures Details Bupropion Danazol Danocrine® Lowering of the seizure threshold Details Bupropion Deflazacort Emflaza Lowering of the seizure threshold Details Bupropion Desonide Desowen Lowering of the seizure threshold Details Bupropion Desonide Topical Desonate® Lowering of the seizure threshold Details Bupropion Deutetrabenazine Austedo Increased deutetrabenazine exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.