Tadalafil

Name: Tadalafil Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

13 interactions 1 explained in plain English

Also sold as: Adcirca Adcirca® Alyq Cialis Cialis® Entadfi® (as a combination product containing Finasteride, Tadalafil) Tadliq

About Tadalafil

A phosphodiesterase inhibitor used to treat erectile dysfunction, enlarged prostate symptoms, and pulmonary arterial hypertension. Read the full Tadalafil drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isosorbide Dinitrate Nitroglycerin Nitroglycerin Spray Nitroglycerin Sublingual Nitroglycerin Topical Nitroglycerin Transdermal Patch

6 Contraindicated 7 Major

All (13) Contraindicated (6) Major (7)

Contraindicated

Tadalafil Isosorbide Dinitrate Isochron Increased hypotensive effects of nitrates Details Tadalafil Nitroglycerin Gonitro Increased hypotensive effects of nitrates Details Tadalafil Nitroglycerin Spray Nitrolingual Increased hypotensive effects of nitrates Details Tadalafil Nitroglycerin Sublingual Nitrostat Increased hypotensive effects of nitrates Details Tadalafil Nitroglycerin Topical Nitro-Bid Increased hypotensive effects of nitrates Details Tadalafil Nitroglycerin Transdermal Patch Minitran® Patch Increased hypotensive effects of nitrates Details

Major

Tadalafil Simvastatin Flolipid Explained An increased risk of myopathy Details Tadalafil Alfuzosin UroXatral An increased risk of hypotension Details Tadalafil Doxazosin Cardura Increased risk of hypotension Details Tadalafil Ketoconazole Topical Extina® Foam Increased tadalafil exposure Details Tadalafil Lenacapavir Injection Sunlenca Increased tadalafil exposure Details Tadalafil Lenacapavir Oral Sunlenca Increased tadalafil exposure Details Tadalafil Letermovir Injection Prevymis Increased CYP3A substrate exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.