Drug & supplement interaction

Polydextrose + Tadalafil

Tadalafil brand names: Cialis, Tadliq.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Polydextrose and Tadalafil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Polydextrose and Tadalafil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tadalafil and Polydextrose in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Polydextrose at all — not against Tadalafil, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Polydextrose safety at a glance

Polydextrose overall Generally safe Generally recognized as safe in foods for most people when consumed in normal amounts.
Pregnancy Use caution Amounts found in foods are likely fine, but check with your doctor before using supplement-level doses.
Breastfeeding Use caution Food amounts are likely fine, but data on concentrated supplement doses are limited.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tadalafil and Polydextrose? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Polydextrose Itself Has Been Linked To

This is not an interaction — nothing below involves Tadalafil. It is the side-effect record for Polydextrose on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Polydextrose, this list is the first place to look.

  • Bloating or gas / Diarrhea Additional detail

    “Orally, polydextrose may cause gas, bloating, and loose stools. These adverse effects are more common when single doses of more than 50 grams or daily doses of more than 90 grams are used. Higher doses of polydextrose (90 grams/day or more) may also cause transient diarrhea in some people.”

    Polydextrose · Natural Medicines adverse-effect record, reported in constipation.

    5 sources cited
    1. 27194. Burdock GA, Flamm WG. A review of the studies of the safety of polydextrose in food. Food Chem Toxicol 1999;37(2-3):233-264. PubMed
    2. 27208. Saku K, Yoshinaga K, Okura Y, et al. Effects of polydextrose on serum lipids, lipoproteins, and apolipoproteins in healthy subjects. Clin Ther 1991;13(2):254-258.
    3. 27212. Tomlin J, Read NW. A comparative study of the effects on colon function caused by feeding ispaghula husk and polydextrose. Aliment Pharmacol Ther 1988;2(6):513-519. PubMed
    4. 27193. Flood MT, Auerbach MH, Craig SA. A review of the clinical toleration studies of polydextrose in food. Food Chem Toxicol 2004;42(9):1531-1542. PubMed
    5. 106527. Colombo J, Carlson SE, Algarín C, et al. Developmental effects on sleep-wake patterns in infants receiving a cow's milk-based infant formula with an added prebiotic blend: a randomized controlled trial. Pediatr Res 2021;89(5):1222-31. PubMed
  • Constipation Additional detail

    Recorded for Polydextrose in the same Natural Medicines adverse-effect record shown under Bloating or gas / Diarrhea above.

  • Dizziness Additional detail

    “Orally, one participant in one clinical study complained of transient dizziness after eating yogurt containing polydextrose 12.5 grams.”

    Polydextrose · Natural Medicines adverse-effect record, reported in vertigo.

    1 source cited
    1. 98660. Ibarra A, Olli K, Pasman W, et al. Effects of polydextrose with breakfast or with a midmorning preload on food intake and other appetite-related parameters in healthy normal-weight and overweight females: An acute, randomized, double-blind, placebo-contro
  • A skin rash Additional detail

    “Orally, giving a formula supplemented with 4 grams/L of polydextrose and galacto-oligosaccharides (GOS) (1:1 ratio) to infants has been associated with an increased incidence of atopic dermatitis in one clinical study. However, it is unclear if this was due to polydextrose, GOS, or the combination.”

    Polydextrose · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 26709. Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr 2007;44(3):359-364. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Polydextrose — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Tadalafil’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Tadalafil column appears here.

From our Q&A

Questions About Polydextrose or Tadalafil

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Polydextrose or Tadalafil, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Tadalafil

This page covers Polydextrose only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tadalafil page lists 144 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Mistletoe (major), Grapefruit (major), Hawthorn (major) and St. John's Wort (major).

By severity: 5 major · 98 moderate · 41 minor.

From our pharmacist’s overview on the Tadalafil page

“Grapefruit juice is the first thing to know about if you take tadalafil (Cialis, Tadliq). It blocks CYP3A4, the enzyme that clears the drug, so blood levels climb and side effects like a steep drop in blood pressure become more likely.”

Reviewed by 2 · Jul 18, 2026

Open the Tadalafil interaction page

One more smart check

Taking Polydextrose as Part of a Dietary Supplement Product? Check It for Interactions

We hold 37 real supplement products containing Polydextrose, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Polydextrose. Even though Polydextrose itself has no known interaction with Tadalafil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Polydextrose and Tadalafil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Polydextrose
Top half

#469 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tadalafil
Top 1%

#16 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Polydextrose reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Polydextrose and Tadalafil records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Polydextrose

What is Polydextrose?

  • Adding dietary fiber
  • Supporting digestive regularity
  • Sugar and fat replacement in foods
  • Promoting gut bacteria (prebiotic)
  • Helping with calorie reduction

Polydextrose is a man-made soluble fiber used widely in foods as a low-calorie bulking agent and prebiotic. It is generally well tolerated, though large amounts can cause gas, bloating, or loose stools. It is not a medicine and should not replace a balanced, fiber-rich diet.

Synthetic carbohydrate made from glucose (dextrose), sorbitol, and citric acid · Added to foods and drinks (baked goods, low-calorie products), powders, fiber supplements

An interaction check asks whether these two react with each other — it does not ask whether Polydextrose is a good idea for someone in your situation. Here is what our Polydextrose record says about it on its own.

Polydextrose: dosing

There is no official medicinal dose for polydextrose, since it is mainly used as a food ingredient rather than a medicine. The amount you get depends on the foods or supplements you choose.If you use a product that contains polydextrose, follow the directions on the label. As with any fiber, it is best to start with a small amount and increase gradually while drinking plenty of water.

From our Polydextrose monograph — the full record covers uses, side effects and every documented interaction.

Read the full Polydextrose monograph & all interactions
Medication

About Tadalafil

What Is Tadalafil Used For?

Brand names: Cialis, Tadliq

Tadalafil tablets (including Cialis and generic tadalafil) are used to treat erectile dysfunction (ED), the symptoms of benign prostatic hyperplasia (BPH — an enlarged prostate), or both conditions together. When used with the drug finasteride to start BPH treatment, this combination is recommended for up to 26 weeks.

Adcirca, Alyq (tablets), and Tadliq (oral suspension) are indicated specifically for pulmonary arterial hypertension (PAH — high blood pressure in the lungs), to improve the ability to exercise.

Most-Reported Side Effects for Tadalafil

From FAERS, the FDA’s public side-effect reporting system (99,210 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 11,917 reports
Headache 10,982 reports
Diarrhea 8,020 reports
Nausea 6,697 reports
Fatigue 6,080 reports
See full Tadalafil drug information
Keep checking

Other Drugs & Polydextrose

Browse every other medication we’ve checked against Polydextrose — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Polydextrose against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Polydextrose list.

See the full Polydextrose interactions page
See every supplement checked against Tadalafil, ranked by severity
Evidence & sources

Polydextrose References

The 7 references that drive our Polydextrose monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr 2007;44(3):359-364. PubMed
  2. Flood MT, Auerbach MH, Craig SA. A review of the clinical toleration studies of polydextrose in food. Food Chem Toxicol 2004;42(9):1531-1542. PubMed
  3. Burdock GA, Flamm WG. A review of the studies of the safety of polydextrose in food. Food Chem Toxicol 1999;37(2-3):233-264. PubMed
  4. Saku K, Yoshinaga K, Okura Y, et al. Effects of polydextrose on serum lipids, lipoproteins, and apolipoproteins in healthy subjects. Clin Ther 1991;13(2):254-258.
  5. Tomlin J, Read NW. A comparative study of the effects on colon function caused by feeding ispaghula husk and polydextrose. Aliment Pharmacol Ther 1988;2(6):513-519. PubMed
  6. Ibarra A, Olli K, Pasman W, et al. Effects of polydextrose with breakfast or with a midmorning preload on food intake and other appetite-related parameters in healthy normal-weight and overweight females: An acute, randomized, double-blind, placebo-contro
  7. Colombo J, Carlson SE, Algarín C, et al. Developmental effects on sleep-wake patterns in infants receiving a cow's milk-based infant formula with an added prebiotic blend: a randomized controlled trial. Pediatr Res 2021;89(5):1222-31. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Polydextrose and Tadalafil Together: Common Questions

Is it safe to take Polydextrose with Tadalafil?
We do not list a known interaction between Polydextrose and Tadalafil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Tadalafil interact with any supplements?
Yes. Tadalafil has documented interactions with 144 supplements in our database — Polydextrose is not one of them. The Tadalafil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Polydextrose monograph Uses, safety profile, and every drug interaction in one place Tadalafil drug information The full plain-English guide to this medication Tadalafil supplement interactions Every supplement checked against Tadalafil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tadalafil and Polydextrose?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.