Drug & supplement interaction

Methylstenbolone + Tadalafil

Tadalafil brand names: Cialis, Tadliq.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Methylstenbolone and Tadalafil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Methylstenbolone and Tadalafil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tadalafil and Methylstenbolone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Methylstenbolone at all — not against Tadalafil, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Methylstenbolone safety at a glance

Methylstenbolone overall Avoid It is an unapproved synthetic anabolic steroid linked to serious liver and hormonal harm.
Pregnancy Possibly Unsafe When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced ferti... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced ferti... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tadalafil and Methylstenbolone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Methylstenbolone Itself Has Been Linked To

This is not an interaction — nothing below involves Tadalafil. It is the side-effect record for Methylstenbolone on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Methylstenbolone, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Yellowing of the skin or eyes Worth acting on Additional detail

    “There is a case of cholestatic jaundice with elevated liver enzymes, dark urine, clay stools, and pruritus in a 26-year-old male, likely related to the use of a product (Super DMZ Rx 2.0) containing methylstenbolone 10 mg and dymethazine 10 mg per capsule. The product was used at manufacturer-recommended doses of two capsules daily for up to 1 month. Liver enzyme levels gradually decreased after discontinuation.”

    Methylstenbolone · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 108298. Agbenyefia P, Arnold CA, Kirkpatrick R 3rd. Cholestatic jaundice with the use of methylstenbolone and dymethazine, designer steroids found in super DMZ Rx 2.0 "Nutritional Supplement": A case report. J Investig Med High Impact Case Rep 2014;2(2):232470961 PubMed
  • Liver problems Worth acting on Additional detail

    “Orally, methylstenbolone is possibly unsafe. As an anabolic androgenic steroid, there is concern that it might cause serious side effects including heart disease and liver injury.”

    Methylstenbolone · Natural Medicines adverse-effect record, reported in cardiovascular disease (cvd).

  • Itching Additional detail

    Recorded for Methylstenbolone in the same Natural Medicines adverse-effect record shown under Yellowing of the skin or eyes above.

Everything above comes from the Natural Medicines adverse-effect record for Methylstenbolone — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Tadalafil’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Tadalafil column appears here.

Special populations

Methylstenbolone in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Methylstenbolone or Tadalafil

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Methylstenbolone or Tadalafil, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Tadalafil

This page covers Methylstenbolone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tadalafil page lists 144 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Mistletoe (major), Grapefruit (major), Hawthorn (major) and St. John's Wort (major).

By severity: 5 major · 98 moderate · 41 minor.

From our pharmacist’s overview on the Tadalafil page

“Grapefruit juice is the first thing to know about if you take tadalafil (Cialis, Tadliq). It blocks CYP3A4, the enzyme that clears the drug, so blood levels climb and side effects like a steep drop in blood pressure become more likely.”

Reviewed by 2 · Jul 18, 2026

Open the Tadalafil interaction page

One more smart check

Taking Methylstenbolone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 27 real supplement products containing Methylstenbolone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Methylstenbolone. Even though Methylstenbolone itself has no known interaction with Tadalafil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Methylstenbolone and Tadalafil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Methylstenbolone
Top half

#697 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tadalafil
Top 1%

#16 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Methylstenbolone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Methylstenbolone and Tadalafil records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Methylstenbolone

What is Methylstenbolone?

  • Muscle building (bodybuilding)
  • Strength gains
  • Body recomposition
  • Athletic performance enhancement

Methylstenbolone is a synthetic, oral anabolic-androgenic steroid that has been sold in some 'prosteroid' or 'designer supplement' products, not a natural herb. It is not an approved or safe dietary supplement, it carries real risks including serious liver damage, and it is banned in sports and prohibited in many countries. We strongly recommend against using it and urge you to speak with a doctor or pharmacist first.

Synthetic compound (not derived from a plant) · Capsules, tablets

An interaction check asks whether these two react with each other — it does not ask whether Methylstenbolone is a good idea for someone in your situation. Here is what our Methylstenbolone record says about it on its own.

Methylstenbolone: dosing

There is no established, safe, or approved dose for methylstenbolone. It is not a recognized medicine or legitimate dietary supplement, so no medical dosing guidance exists.We will not provide dosing amounts because doing so could encourage harmful use. If you have taken a product that contains methylstenbolone, stop and talk with a healthcare professional. Never assume a product is safe just because it is sold online or in a store.

From our Methylstenbolone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Methylstenbolone monograph & all interactions
Medication

About Tadalafil

What Is Tadalafil Used For?

Brand names: Cialis, Tadliq

Tadalafil tablets (including Cialis and generic tadalafil) are used to treat erectile dysfunction (ED), the symptoms of benign prostatic hyperplasia (BPH — an enlarged prostate), or both conditions together. When used with the drug finasteride to start BPH treatment, this combination is recommended for up to 26 weeks.

Adcirca, Alyq (tablets), and Tadliq (oral suspension) are indicated specifically for pulmonary arterial hypertension (PAH — high blood pressure in the lungs), to improve the ability to exercise.

Most-Reported Side Effects for Tadalafil

From FAERS, the FDA’s public side-effect reporting system (99,210 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 11,917 reports
Headache 10,982 reports
Diarrhea 8,020 reports
Nausea 6,697 reports
Fatigue 6,080 reports
See full Tadalafil drug information
Keep checking

Other Drugs & Methylstenbolone

Browse every other medication we’ve checked against Methylstenbolone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Methylstenbolone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Methylstenbolone list.

See the full Methylstenbolone interactions page
See every supplement checked against Tadalafil, ranked by severity
Evidence & sources

Methylstenbolone References

The 2 references that drive our Methylstenbolone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Agbenyefia P, Arnold CA, Kirkpatrick R 3rd. Cholestatic jaundice with the use of methylstenbolone and dymethazine, designer steroids found in super DMZ Rx 2.0 "Nutritional Supplement": A case report. J Investig Med High Impact Case Rep 2014;2(2):232470961 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Methylstenbolone and Tadalafil Together: Common Questions

Is it safe to take Methylstenbolone with Tadalafil?
We do not list a known interaction between Methylstenbolone and Tadalafil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Tadalafil interact with any supplements?
Yes. Tadalafil has documented interactions with 144 supplements in our database — Methylstenbolone is not one of them. The Tadalafil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Methylstenbolone monograph Uses, safety profile, and every drug interaction in one place Tadalafil drug information The full plain-English guide to this medication Tadalafil supplement interactions Every supplement checked against Tadalafil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tadalafil and Methylstenbolone?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.