Methasterone Drug Interactions, Uses, Side Effects & More

Interaction report

Drugs that interact with Methasterone

0 medications have a known interaction with Methasterone, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Methasterone. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Methasterone combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Monograph

Methasterone: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed June 2026 ·

The bottom line

Methasterone (also called methyldrostanolone or 'Superdrol') is a synthetic, oral anabolic steroid — not a dietary supplement, herb, or natural product. It is a controlled substance in the United States and has been linked to serious liver damage and other harms, so it should not be used outside of legitimate medical or research settings.

Part used: Synthetic compound (not derived from a plant)
Common forms: Oral capsules or tablets (illicit/gray-market products)

People commonly use it for

Muscle building
Athletic performance
Strength gains
Body recomposition

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallBest avoided

Methasterone is a controlled anabolic steroid linked to serious liver injury and is not a legitimate dietary supplement.

PregnancyPossibly Unsafe

When used orally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility,...

Read the full pregnancy detail

BreastfeedingPossibly Unsafe

When used orally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility,...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Methasterone is a man-made (synthetic) anabolic-androgenic steroid. It is sometimes sold under names like methyldrostanolone or the brand name Superdrol. Despite sometimes appearing on the shelves of supplement stores or online, it is not a natural herb, plant, or true dietary supplement. It is a designer steroid created in a lab.

In the past, methasterone was marketed illegally as a "prohormone" or workout supplement to people who wanted to build muscle quickly. After reports of harm, it was classified as a Schedule III controlled substance in the United States, making it illegal to sell or possess without a prescription. Today there is no approved medical use for it.

How it works

Methasterone is a modified form of testosterone. Like other anabolic steroids, it is thought to attach to androgen receptors in muscle and other tissues, signaling the body to build more muscle protein and reducing muscle breakdown.

It is also "17-alpha-alkylated," a chemical change that lets the steroid survive being swallowed and pass through the digestive system. Unfortunately, this same change is what makes oral steroids like methasterone especially toxic to the liver. Much of what is known about its effects comes from how similar steroids behave rather than from careful study of methasterone itself.

Effectiveness

Does Methasterone work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 5 uses evaluated

5 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

For Methasterone, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 5 conditions — evidence insufficient to rate

Insufficient Reliable Evidence To Rate Athletic performance