Drug & supplement interaction

Fermented Wheat Germ Extract + Tadalafil

Tadalafil brand names: Cialis, Tadliq.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Fermented Wheat Germ Extract and Tadalafil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Fermented Wheat Germ Extract and Tadalafil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tadalafil and Fermented Wheat Germ Extract in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Fermented Wheat Germ Extract safety at a glance

Fermented Wheat Ge... overall Use caution Generally tolerated in short-term studies, but long-term safety is not well established and people with cancer should clear it with their care team.
Pregnancy Avoid There is not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety has not been studied, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tadalafil and Fermented Wheat Germ Extract? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tadalafil

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tadalafil is filed under 5 classifications — including phosphodiesterase-5 inhibitors, vasodilators, cytochrome p450 3a4 (cyp3a4) substrates. Fermented Wheat Germ Extract has documented interactions with 2 drug classes — the most serious being immunosuppressants (moderate) and serotonergic drugs (moderate) — and none of Tadalafil’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Fermented Wheat Germ Extract Does Interact With Other Medications

Fermented Wheat Germ Extract has 303 moderate known drug interactions in our database — Tadalafil isn’t one of them. If you take anything else, check it against the full list below.

Moderate 303 No known interaction 2,527 (incl. Tadalafil)
Taking anything else?

Check Another of Your Medications Against Fermented Wheat Germ Extract

Covers the 2,830 medications we’ve checked against Fermented Wheat Germ Extract. Pick one to open its full report.

What to actually watch for

What Fermented Wheat Germ Extract Itself Has Been Linked To

This is not an interaction — nothing below involves Tadalafil. It is the side-effect record for Fermented Wheat Germ Extract on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Fermented Wheat Germ Extract, this list is the first place to look.

  • Bloating or gas / Constipation / Vomiting Additional detail

    “Orally, fermented wheat germ extract may cause diarrhea, nausea, flatulence, satiation, soft stools, and constipation. In one clinical study, diarrhea and nausea with or without vomiting were reported in 6% and 3% of patients, respectively.”

    Fermented Wheat Germ Extract · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 27703. Jakab F, Shoenfeld Y, Balogh A, et al. A medical nutriment has supportive value in the treatment of colorectal cancer. Br J Cancer 2003;89(3):465-469. PubMed
  • Diarrhea / Nausea Additional detail

    “Orally, fermented wheat germ extract seems to be well tolerated.

    Most Common Adverse Effects:

    Orally: Diarrhea, nausea.”

    Fermented Wheat Germ Extract · Natural Medicines adverse-effect record, reported in diarrhea.

Everything above comes from the Natural Medicines adverse-effect record for Fermented Wheat Germ Extract — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Tadalafil’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Tadalafil column appears here.

From our Q&A

Questions About Fermented Wheat Germ Extract or Tadalafil

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Fermented Wheat Germ Extract or Tadalafil, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Tadalafil

This page covers Fermented Wheat Germ Extract only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tadalafil page lists 144 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Mistletoe (major), Grapefruit (major), Hawthorn (major) and St. John's Wort (major).

By severity: 5 major · 98 moderate · 41 minor.

From our pharmacist’s overview on the Tadalafil page

“Grapefruit juice is the first thing to know about if you take tadalafil (Cialis, Tadliq). It blocks CYP3A4, the enzyme that clears the drug, so blood levels climb and side effects like a steep drop in blood pressure become more likely.”

Reviewed by 2 · Jul 18, 2026

Open the Tadalafil interaction page

How much people look this up

Where Fermented Wheat Germ Extract and Tadalafil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Fermented Wheat Germ Extract
Steady interest

#1,413 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tadalafil
Top 1%

#16 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Fermented Wheat Germ Extract reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Fermented Wheat Germ Extract and Tadalafil records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Fermented Wheat Germ Extract

What is Fermented Wheat Germ Extract?

  • Cancer supportive care (as a complementary product)
  • Immune support
  • General wellness during cancer treatment
  • Antioxidant support
  • Fatigue during illness

Fermented wheat germ extract is a supplement made by fermenting wheat germ with yeast, and it is most often marketed for people going through cancer treatment. While some early research and a few small studies are interesting, the overall evidence is limited and far from conclusive, so it should never replace standard medical care. Talk with your oncologist or pharmacist before using it, since it is a supplement and not an approved treatment.

Triticum aestivum · Poaceae · Wheat germ (fermented with baker's yeast, Saccharomyces cerevisiae) · Powder (to mix in water or juice), capsules, tablets

An interaction check asks whether these two react with each other — it does not ask whether Fermented Wheat Germ Extract is a good idea for someone in your situation. Here is what our Fermented Wheat Germ Extract record says about it on its own.

Fermented Wheat Germ Extract: dosing

There is no official, standardized dose for fermented wheat germ extract that applies to everyone. Do not assume that taking more will work better, and do not use it as a replacement for prescribed therapy.

From our Fermented Wheat Germ Extract monograph — the full record covers uses, side effects and every documented interaction.

Read the full Fermented Wheat Germ Extract monograph & all interactions
Medication

About Tadalafil

What Is Tadalafil Used For?

Brand names: Cialis, Tadliq

Tadalafil tablets (including Cialis and generic tadalafil) are used to treat erectile dysfunction (ED), the symptoms of benign prostatic hyperplasia (BPH — an enlarged prostate), or both conditions together. When used with the drug finasteride to start BPH treatment, this combination is recommended for up to 26 weeks.

Adcirca, Alyq (tablets), and Tadliq (oral suspension) are indicated specifically for pulmonary arterial hypertension (PAH — high blood pressure in the lungs), to improve the ability to exercise.

Most-Reported Side Effects for Tadalafil

From FAERS, the FDA’s public side-effect reporting system (99,210 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 11,917 reports
Headache 10,982 reports
Diarrhea 8,020 reports
Nausea 6,697 reports
Fatigue 6,080 reports
See full Tadalafil drug information
Keep checking

Other Drugs & Fermented Wheat Germ Extract

Browse every other medication we’ve checked against Fermented Wheat Germ Extract — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
303Moderate
0Minor
2,526No known interaction
303 Moderate 2,526 No interaction
Moderate

303 interactions

Showing 60 of 303 moderate interactions — see all 303 on the Fermented Wheat Germ Extract page.

No interaction 2,526 drugs checked — show the list

We also checked Fermented Wheat Germ Extract against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,526 medications checked with no known interaction — see the full Fermented Wheat Germ Extract list.

See the full Fermented Wheat Germ Extract interactions page
See every supplement checked against Tadalafil, ranked by severity
Evidence & sources

Fermented Wheat Germ Extract References

The 7 references that drive our Fermented Wheat Germ Extract monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Jakab F, Shoenfeld Y, Balogh A, et al. A medical nutriment has supportive value in the treatment of colorectal cancer. Br J Cancer 2003;89(3):465-469. PubMed
  2. Hidvegi M, Raso E, Tomoskozi Farkas R, Lapis K, Szende B. Effect of MSC on the immune response of mice. Immunopharmacology 1999;41(3):183-186. PubMed
  3. Sukkar SG, Rossi E. Oxidative stress and nutritional prevention in autoimmune rheumatic diseases. Autoimmun Rev 2004;3(3):199-206. PubMed
  4. Ehrenfeld M, Blank M, Shoenfeld Y, Hidvegi M. AVEMAR (a new benzoquinone-containing natural product) administration interferes with the Th2 response in experimental SLE and promotes amelioration of the disease. Lupus 2001;10(9):622-627. PubMed
  5. Gidali J, Hidvégi M, Fehér I, et al. The effect of Avemar treatment on the regeneration of leukocytes, thrombocytes and reticulocytes in sublethally irradiated or cyclophosphamide treated mice. First Congress of the Hungarian Society of Clinical Oncology,
  6. Vucskits, AV, Hullar, I, Bersenyi, A, Andrasofszky, E, Kulcsar, M, Szabo, J. Effect of fulvic and humic acids on performance, immune response and thyroid function in rats. J Anim Physiol Anim Nutr (Berl) 2010;94(6):721-728. PubMed
  7. Hu Z, Zhao P, Liao A, et al. Fermented Wheat Germ Alleviates Depression-like Behavior in Rats with Chronic and Unpredictable Mild Stress. Foods 2023;12(5):920. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Fermented Wheat Germ Extract and Tadalafil Together: Common Questions

Is it safe to take Fermented Wheat Germ Extract with Tadalafil?
We do not list a known interaction between Fermented Wheat Germ Extract and Tadalafil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Fermented Wheat Germ Extract and Tadalafil combination checked?
Interactions in our licensed database are recorded against drug classes. Tadalafil is filed under 5 classifications, and Fermented Wheat Germ Extract has documented interactions with 2 drug classes — none of Tadalafil's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Fermented Wheat Germ Extract interact with any other medications?
Yes. Fermented Wheat Germ Extract has 303 documented drug interactions in our database — Tadalafil is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tadalafil interact with any supplements?
Yes. Tadalafil has documented interactions with 144 supplements in our database — Fermented Wheat Germ Extract is not one of them. The Tadalafil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Fermented Wheat Germ Extract monograph Uses, safety profile, and every drug interaction in one place Tadalafil drug information The full plain-English guide to this medication Tadalafil supplement interactions Every supplement checked against Tadalafil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 7 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tadalafil and Fermented Wheat Germ Extract?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.