Tretinoin

15 interactions
Also sold as: Altreno Atralin Avita Refissa Renova Retin-A Tretin X Vesanoid®
About Tretinoin

Tretinoin is used to treat acute promyelocytic leukemia (APL; a type of cancer in which there are too many immature blood cells in the blood and bone marrow) in people who have not been helped by other types of chemotherapy or whose condition has improved but then worsened following treatment with other types of chemot… Read the full Tretinoin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Aminocaproic Acid Aminocaproic Acid Injection Demeclocycline Doxycycline Injection Eravacycline Injection Ketoconazole Topical
11 Major 4 Moderate
All (15) Major (11) Moderate (4)

Major

Tretinoin Aminocaproic Acid Amicar Increased risk of thrombosis Details Tretinoin Aminocaproic Acid Injection Amicar Increased risk of thrombosis Details Tretinoin Demeclocycline Declomycin® An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Tretinoin Doxycycline Injection Acticlate An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Tretinoin Eravacycline Injection Xerava An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Tretinoin Ketoconazole Topical Extina® Foam Increased tretinoin exposure and an increased risk of tretinoin-related adverse reactions Details Tretinoin Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Tretinoin Minocycline Amzeeq An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Tretinoin Minocycline Topical Amzeeq An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Tretinoin Omadacycline Nuzyra An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Tretinoin Omadacycline Injection Nuzyra An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details

Moderate

Tretinoin Dexamethasone Injection Decadron Decreased efficacy of tretinoin Details Tretinoin Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Decreased efficacy of tretinoin Details Tretinoin Hydrocortisone Ala-Cort Decreased efficacy of tretinoin Details Tretinoin Hydrocortisone Injection A-Hydrocort® Decreased efficacy of tretinoin Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.