Tretinoin

Name: Tretinoin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

15 interactions

Also sold as: Altreno Atralin Avita Refissa Renova Retin-A Tretin X Vesanoid®

About Tretinoin

Tretinoin is used to treat acute promyelocytic leukemia (APL; a type of cancer in which there are too many immature blood cells in the blood and bone marrow) in people who have not been helped by other types of chemotherapy or whose condition has improved but then worsened following treatment with other types of chemot… Read the full Tretinoin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Aminocaproic Acid Aminocaproic Acid Injection Demeclocycline Doxycycline Injection Eravacycline Injection Ketoconazole Topical

11 Major 4 Moderate

All (15) Major (11) Moderate (4)

Moderate

Tretinoin Dexamethasone Injection Decadron Decreased efficacy of tretinoin Details Tretinoin Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Decreased efficacy of tretinoin Details Tretinoin Hydrocortisone Ala-Cort Decreased efficacy of tretinoin Details Tretinoin Hydrocortisone Injection A-Hydrocort® Decreased efficacy of tretinoin Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.