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Dietary supplement

Bergamot 375 Ingredients & Drug Interactions

by ProCaps

Bergamot 375 label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bergamot 375 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bergamot 375 is a dietary supplement by ProCaps with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, heart and metabolic health, anxiety and stress (aromatherapy).Based on those ingredients, 410 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bergamot Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bergamot 375 by ProCaps

Ask about any prescription or over-the-counter medication and we check it for interactions with Bergamot 375 by ProCaps — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bergamot 375 by ProCaps

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Bergamot 375 contains one active ingredient: bergamot fruit extract, supplied at 375 mg per capsule. The capsule itself is made from plant cellulose (a natural fiber used as a capsule shell), which is an inactive ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Supports healthy cholesterol metabolism and cardiovascular health.
  • We looked for evidence on: Hyperlipidemia, Metabolic syndrome, Nonalcoholic fatty liver disease (NAFLD), Obesity, Impaired glucose tolerance (prediabetes), Dyslipidemia — and 3 related terms.
  • The strongest evidence on file: Bergamot is rated "Possibly Effective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Bergamot is rated "Insufficient Reliable Evidence To Rate" for Nonalcoholic fatty liver disease (NAFLD), Obesity, Impaired glucose tolerance (prediabetes), Metabolic syndrome.

Bergamot extract is possibly effective for high cholesterol (hyperlipidemia) — the main reason people take this supplement. For mental alertness, the evidence leans toward possibly ineffective.

The data we hold doesn't yet establish whether it works for nonalcoholic fatty liver disease (NAFLD) or autism spectrum disorder — the evidence is too thin to rate either way.

The evidence, ingredient by ingredient Bergamot

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oral bergamot extract appears generally well tolerated when used short-term. The main caution: the essential oil can be toxic if swallowed and can cause sun-related skin reactions, especially with sun exposure.

One person in clinical trials reported heartburn. If you apply bergamot topically or handle the peel or oil frequently, watch for blisters, redness, pustules, scabs, pigment spots, or photosensitivity — fair-skinned people are at higher risk.

During pregnancy, there isn't enough safety information, so the data advises against use. The same goes for breastfeeding — safety is unknown, so it's safer to avoid it.

Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Bergamot

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bergamot.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 410 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Bergamot 375, check with your pharmacist if you use photosensitizing drugs (Moderate interaction) — medications that increase skin sensitivity to sun, including certain antibiotics, NSAIDs, and some heart or psychiatric drugs. Also check if you take antidiabetes drugs (Moderate interaction) — bergamot may boost their blood-sugar-lowering effect and raise your low blood sugar risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Bergamot 375 is used primarily for cholesterol support and is generally well tolerated by mouth in the short term. If you take photosensitizing medications or diabetes drugs, check your exact medications with the tool below before starting.

Avoid during pregnancy and breastfeeding. Chat with your pharmacist about whether this fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bergamot 375, straight from the product label.

Brand ProCaps
Barcode (UPC) 887231
Net contents 240 Easy-To-Swallow Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 331517
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bergamot 375 by ProCaps, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
240
UPC/BARCODE
887231
IngredientAmount% DV
Bergamot Fruit Extract375 mg--

Other ingredients: Plant Cellulose, Natural

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use Consume one capsule daily. You can increase your intake as required or as guided by your physician.

General Statements

For questions about the use of this product call 800.800.1200. Questions? Reorder? 800.800.1200 PROCAPS.COM

Formulation

Since 1979, Unsurpassed purity, quality and efficacy. 100% Solar production Zero-carbon footprint 100% Solar

Supports healthy cholesterol metabolism and cardiovascular health

Contains no additives or common allergens Contains No milk, soy, yeast, wheat, gluten, sodium, salt, sugar, fat, cholesterol, color, preservative, common allergens, genetically modified (GMO) ingredients or manufacturing additives.

Brand IP Statement(s)

Copyright 2024 ProCaps Laboratories

FDA Statement of Identity

Dietary Supplement

Formula

Bergamot 375 provides a standardized extract of bergamot (Citrus bergamia), a citrus fruit that is native to southern Italy and recognized for its rich content of protective compounds. Bergamot has not been used for centuries for its wide-ranging health benefits and it is the well-known flavor of earl gray tea. Our uniquely standardized extract of bergamot fruit is rich in protective compounds that are intended and targeted to support healthy cholesterol metabolism thereby supporting heart and cardiovascular health. Given the important role that cholesterol metabolism plays in heart health, our Bergamot 375 is a common sense, natural addition to supporting cardiovascular health.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bergamot 375 by ProCaps label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bergamot 375 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bergamot 375 by ProCaps

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container240 Amounts shown are per serving.

Bergamot Fruit Extract

Interacts with
410 drugs
375 mg per serving Form: Flavonoids

Bergamot is a Mediterranean citrus fruit, and its standardized extract is most often used to support cholesterol and heart health, with some early but...

Bergamot Fruit Extract monograph & interactions

Other (inactive) ingredients: Plant Cellulose, Natural. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bergamot 375 by ProCaps Drug Interactions

Want to check YOUR meds against Bergamot 375?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
410Drugs
410 Moderate

Ingredients driving the most interactions

Bergamot Fruit Extract 410

Individual Drug Interactions

The ingredients in Bergamot 375 interact with 410 drugs. Click any drug to see the details.

1 of the 1 ingredient in Bergamot 375 interact with drugs. Each result below shows which ingredient is responsible. Bergamot Fruit Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Bergamot 375 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bergamot Fruit Extract2 drug types · 410 drugs

Antidiabetes Drugs

Theoretically, taking bergamot with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that bergamot juice has hypoglycemic effects.

Likelihood Possible Evidence D
Photosensitizing Drugs

Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Bergamot contains bergapten, which has photosensitizing effects.

Likelihood Probable Evidence D
Bergamot Fruit Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bergamot 375, from the product label.

ProCaps

See all ProCaps products
Name
ProCaps Labs
City
Henderson
State
NV
ZipCode
89011
Phone Number
800.800.1200
Web Address
ProCaps.com
Pharmacist Counseling Corner

Bergamot 375 by ProCaps: Common Questions

Does Bergamot 375 by ProCaps interact with any medications?
Yes. Based on its ingredients, Bergamot 375 has a known interaction with 410 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bergamot 375 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is bergamot extract safe to use if I'm pregnant or breastfeeding?
The safety data advises against bergamot during pregnancy — there isn't enough information to know it's safe. Breastfeeding safety is also unknown, so avoiding it is the safer choice. Talk with your doctor or pharmacist before use if you're pregnant, planning pregnancy, or nursing.
What side effects might I get from taking this?
Orally, bergamot extract is generally well tolerated short-term. One person in a clinical trial reported heartburn. If you handle the peel or oil frequently, or apply it to skin, you may develop blisters, redness, pustules, skin lesions, or dark spots — and photosensitivity (extra sun sensitivity), especially if you have fair skin.
What is bergamot extract actually used for?
Bergamot extract is possibly effective for high cholesterol (hyperlipidemia) — that's the main use supported by evidence. For mental alertness, evidence suggests it's likely not effective. We don't yet have solid evidence on whether it helps nonalcoholic fatty liver disease or autism spectrum disorder.
Can I use the essential oil topically, or should I stick to the capsule?
The essential oil can be toxic if swallowed and can cause sun-related skin reactions when applied to skin. This capsule is bergamot fruit extract taken by mouth, which is generally well tolerated short-term. If you're considering topical or aromatherapy use, talk with your pharmacist — the safety profile is different.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bergamot 375 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bergamot 375 label
Go deeper

The Full Monographs Behind Bergamot 375’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bergamot

Interacts with 410 drugs

Bergamot is a Mediterranean citrus fruit, and its standardized extract is most often used to support cholesterol and heart health, with some early but promising research. The essential oil i...

Read the full Bergamot monograph →
Sources

Sources & How We Checked

Bergamot 375's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bergamot 17 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Naganuma M, Hirose S, Nakayama Y, et al. A study of the phototoxicity of lemon oil. Arch Dermatol Res 1985;278:31-6. . PubMed
  4. Kaddu, S., Kerl, H., and Wolf, P. Accidental bullous phototoxic reactions to bergamot aromatherapy oil. J.Am.Acad.Dermatol. 2001;45(3):458-461. PubMed
  5. Finsterer, J. Earl Grey tea intoxication. Lancet 4-27-2002;359(9316):1484. PubMed
  6. Gruson, L. M. and Chang, M. W. Berloque dermatitis mimicking child abuse. Arch.Pediatr.Adolesc.Med. 2002;156(11):1091-1093. PubMed
  7. Weisenseel, P. and Woitalla, S. [Toxic mustard plaster dematitis and phototoxic dematitis after application of bergamot oil]. MMW.Fortschr.Med. 12-15-2005;147(51-52):53, 55.
  8. Placzek, M., Fromel, W., Eberlein, B., Gilbertz, K. P., and Przybilla, B. Evaluation of phototoxic properties of fragrances. Acta Derm.Venereol. 2007;87(4):312-316. PubMed
  9. Mollace, V., Sacco, I., Janda, E., Malara, C., Ventrice, D., Colica, C., Visalli, V., Muscoli, S., Ragusa, S., Muscoli, C., Rotiroti, D., and Romeo, F. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. F PubMed
  10. Morliere, P., Huppe, G., Averbeck, D., Young, A. R., Santus, R., and Dubertret, L. In vitro photostability and photosensitizing properties of bergamot oil. Effects of a cinnamate sunscreen. J.Photochem.Photobiol.B 1990;7(2-4):199-208. PubMed
  11. Young, A. R., Walker, S. L., Kinley, J. S., Plastow, S. R., Averbeck, D., Morliere, P., and Dubertret, L. Phototumorigenesis studies of 5-methoxypsoralen in bergamot oil: evaluation and modification of risk of human use in an albino mouse skin model. J.P PubMed
  12. Girard, J., Unkovic, J., Delahayes, J., and Lafille, C. [Phototoxicity of Bergamot oil. Comparison between humans and guinea pigs]. Dermatologica 1979;158(4):229-243.
  13. Zaynoun, S. T., Johnson, B. E., and Frain-Bell, W. A study of oil of bergamot and its importance as a phototoxic agent. II. Factors which affect the phototoxic reaction induced by bergamot oil and psoralen derivatives. Contact Dermatitis 1977;3(5):225-23 PubMed
  14. Zacher, K. D. and Ippen, H. [Contact dermatitis caused by bergamot oil]. Derm.Beruf.Umwelt. 1984;32(3):95-97.
  15. Yasui, Y. and Hirone, T. Action spectrum for bergamot-oil phototoxicity measured by sunburn cell counting. J.Dermatol. 1994;21(5):319-322. PubMed
  16. Zaynoun, S. T., Johnson, B. E., and Frain-Bell, W. A study of oil of bergamot and its importance as a phototoxic agent. I. Characterization and quantification of the photoactive component. Br.J.Dermatol. 1977;96(5):475-482. PubMed
  17. Bruno A, Pandolfo G, Crucitti M, Cedro C, Zoccali RA, Muscatello MRA. Bergamot Polyphenolic Fraction Supplementation Improves Cognitive Functioning in Schizophrenia: Data From an 8-Week, Open-Label Pilot Study. J Clin Psychopharmacol 2017;37(4):468-71. PubMed

See these in context on the Bergamot monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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