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Dietary supplement

Biothin Bergamot 500 mg Ingredients & Drug Interactions

by Dr. Mercola

Biothin Bergamot 500 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Biothin Bergamot 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Biothin Bergamot 500 mg is a dietary supplement by Dr. Mercola with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, heart and metabolic health, anxiety and stress (aromatherapy).Based on those ingredients, 418 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bergamonte. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Biothin Bergamot 500 mg by Dr. Mercola

Ask about any prescription or over-the-counter medication and we check it for interactions with Biothin Bergamot 500 mg by Dr. Mercola — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Biothin Bergamot 500 mg by Dr. Mercola

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Bergamonte” is listed as a grouped ingredient — the label gives one combined amount (500 mg) without saying how much of each component you get.

Biothin Bergamot 500 mg contains 2 active ingredients: pectin and polyphenols. Pectin is a fiber that's also found in fruit and plant cell walls; it's used in this product to help manage cholesterol levels.

Polyphenols are plant compounds with antioxidant properties, though we have no interaction data on file for this ingredient. The product also contains inactive ingredients — pullulan and brown rice flour — as capsule material and filler.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Heart and metabolic health support.
  • We looked for evidence on: Hypercholesterolemia, Hyperlipidemia, Metabolic syndrome, Nonalcoholic fatty liver disease (NAFLD), Impaired glucose tolerance (Prediabetes), Cardiovascular health — and 1 related terms.
  • The strongest evidence on file: Pectin is rated "Possibly Effective" for Hypercholesterolemia (Natural Medicines).
  • Also on file: Pectin is rated "Insufficient Reliable Evidence To Rate" for Impaired glucose tolerance (Prediabetes).

Pectin is rated possibly effective for high cholesterol (hypercholesterolemia). For prediabetes (impaired glucose tolerance) and protection from radiation exposure, the evidence isn't established — we don't have enough reliable data to say whether it works for those purposes.

The effectiveness of polyphenols in this product is not rated in our data.

The evidence, ingredient by ingredient Bergamot Pectin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pectin from food and typical supplement amounts is generally well tolerated. The most common side effects are digestive: diarrhea, gas, loose stools, and mild cramps.

Allergic reactions are rare but possible, especially in people with oral allergy syndrome or sensitivity to citrus — very rarely, these can be severe (anaphylaxis). For pregnancy, pectin at food doses is likely safe, though concentrated supplements haven't been well studied, so talk with your doctor.

The same goes for breastfeeding — dietary amounts are probably fine, but supplement safety isn't well established.

Side effects, ingredient by ingredient Bergamot Pectin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pectin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 23 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, check any heart medications (especially digoxin), cholesterol drugs in the statin family (particularly lovastatin), and tetracycline antibiotics — pectin may reduce how well your body absorbs them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take digoxin, any statin for cholesterol, or tetracycline antibiotics, check with us or your pharmacist before starting this product — pectin can interfere with how your body absorbs these drugs. Otherwise, if you're looking to help manage cholesterol and don't have those medications, pectin may be worth a try.

Talk to your pharmacist about whether it fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Biothin Bergamot 500 mg, straight from the product label.

Brand Dr. Mercola
Barcode (UPC) 810094213107
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 327147
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Biothin Bergamot 500 mg by Dr. Mercola, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
810094213107
IngredientAmount% DV
Pectin40 mg--
Polyphenols190 mg--
Bergamonte500 mg--

Other ingredients: Pullulan, Brown Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Adults, as a dietary supplement, take one (1) capsule daily.

Precautions

Keep out of reach of children.

Do not use if safety seal is broken.

If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.

Formula

Biothin Bergamot 500 mg per capsule

Seals/Symbols

USDA Organic

FDA Statement of Identity

Dietary Supplement

Formulation

Certified organic by: Organic Certifiers

General Statements

Providing quality products since 2001.

Brand IP Statement(s)

Bergamonte is a registered trademark of HP Ingredients Corp.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Biothin Bergamot 500 mg by Dr. Mercola label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Biothin Bergamot 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Biothin Bergamot 500 mg by Dr. Mercola

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Bergamonte

Interacts with
410 drugs
500 mg per serving Form: Bergamot Fruit Extract, Full Spectrum

Bergamot is a Mediterranean citrus fruit, and its standardized extract is most often used to support cholesterol and heart health, with some early but...

Bergamonte monograph & interactions

Other (inactive) ingredients: Pullulan, Brown Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Biothin Bergamot 500 mg by Dr. Mercola Drug Interactions

Want to check YOUR meds against Biothin Bergamot 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
418Drugs
418 Moderate

Ingredients driving the most interactions

Bergamonte 410

Individual Drug Interactions

The ingredients in Biothin Bergamot 500 mg interact with 418 drugs. Click any drug to see the details.

1 of the 1 ingredient in Biothin Bergamot 500 mg interact with drugs. Each result below shows which ingredient is responsible. Bergamonte

Each ingredient & the kinds of drugs it affects

For each ingredient in Biothin Bergamot 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bergamonte2 drug types · 410 drugs

Antidiabetes Drugs

Theoretically, taking bergamot with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that bergamot juice has hypoglycemic effects.

Likelihood Possible Evidence D
Photosensitizing Drugs

Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Bergamot contains bergapten, which has photosensitizing effects.

Likelihood Probable Evidence D
Bergamonte full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Biothin Bergamot 500 mg, from the product label.

Dr. Mercola

See all Dr. Mercola products
Name
NHP
Street Address
125 SW 3rd Place
City
Cape Coral
State
FL
ZipCode
33991
Phone Number
(877) 985-2696
Pharmacist Counseling Corner

Biothin Bergamot 500 mg by Dr. Mercola: Common Questions

Does Biothin Bergamot 500 mg by Dr. Mercola interact with any medications?
Yes. Based on its ingredients, Biothin Bergamot 500 mg has a known interaction with 418 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Biothin Bergamot 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this give me stomach problems?
A small number of people report digestive side effects like diarrhea, gas, loose stools, or mild cramps. Most people tolerate pectin well. If it bothers you, start with a lower dose or take it with food.
Is it safe if I'm pregnant?
At normal food amounts, pectin is likely safe in pregnancy. But this is a concentrated supplement, and we don't have good safety data on high doses during pregnancy. Talk with your doctor before taking it.
Can I take this while breastfeeding?
Dietary amounts of pectin are probably fine, but we don't have reliable safety data on supplements while breastfeeding. Check with your doctor or pharmacist to be sure.
Does pectin actually lower cholesterol?
We rate pectin as possibly effective for high cholesterol based on the evidence we hold. It may help, but results aren't guaranteed — talk with your doctor about how it fits into your overall plan.
What if I have a fruit or citrus allergy?
Pectin can trigger allergic reactions in people with oral allergy syndrome, especially to citrus. If you have a known allergy to citrus or a history of oral allergy syndrome, check with your pharmacist before taking this product.
What are polyphenols for?
Polyphenols are plant compounds with antioxidant properties. We don't have interaction or effectiveness data on file for this ingredient, so we can't tell you much more about it in this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Biothin Bergamot 500 mg label
Go deeper

The Full Monographs Behind Biothin Bergamot 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bergamot

Interacts with 410 drugs

Bergamot is a Mediterranean citrus fruit, and its standardized extract is most often used to support cholesterol and heart health, with some early but promising research. The essential oil i...

Read the full Bergamot monograph → Herb & supplement monograph

Pectin

Interacts with 23 drugs

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly help with cholesterol, blood sugar, and di...

Read the full Pectin monograph →
Sources

Sources & How We Checked

Biothin Bergamot 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pectin 11 references
  1. Jaakkola MS, et al. Asthma caused by occupational exposure to pectin. J Allergy Clin Immunol 1997;100:575-6. PubMed
  2. Westphal W, et al. [Exogenous allergic asthma following pectin exposure-a new occupational allergen]. Pneumologie 1990;44(Suppl 1):337-8.
  3. Baldwin JL, et al. Pectin-induced occupational asthma. Chest 1993;104:1936-7. PubMed
  4. Cohen AJ, Forse MS, Tarlo SM. Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 1993;103:309-11.
  5. Kraut A, et al. Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 1992;102:1605-7. PubMed
  6. Richter WO, Jacob BG, Schwandt P. Interaction between fibre and lovastatin. Lancet 1991;338:706.
  7. Albert KS, Ayres JW, DiSanto AR, et al. Influence of kaolin-pectin suspension on digoxin bioavailability. J Pharm Sci 1978;67:1582-6. PubMed
  8. Albert KS, Welch RD, DeSante KA, et al. Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture. J Pharm Sci 1979;68:586-8. PubMed
  9. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  10. Federal Register April 17,2003. Anti-Diarrheal Products for over-the-counter human use; final monograph. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/03-9380.pdf (Accessed 27 December 2004).
  11. Washio K, Nakamura M, Sato N, et al. Anaphylaxis in a pectin- and cashew nut-allergic child caused by a citrus bath. Allergol Int 2022;71(1):155-157. PubMed

See these in context on the Pectin monograph →

Bergamot 17 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Naganuma M, Hirose S, Nakayama Y, et al. A study of the phototoxicity of lemon oil. Arch Dermatol Res 1985;278:31-6. . PubMed
  4. Kaddu, S., Kerl, H., and Wolf, P. Accidental bullous phototoxic reactions to bergamot aromatherapy oil. J.Am.Acad.Dermatol. 2001;45(3):458-461. PubMed
  5. Finsterer, J. Earl Grey tea intoxication. Lancet 4-27-2002;359(9316):1484. PubMed
  6. Gruson, L. M. and Chang, M. W. Berloque dermatitis mimicking child abuse. Arch.Pediatr.Adolesc.Med. 2002;156(11):1091-1093. PubMed
  7. Weisenseel, P. and Woitalla, S. [Toxic mustard plaster dematitis and phototoxic dematitis after application of bergamot oil]. MMW.Fortschr.Med. 12-15-2005;147(51-52):53, 55.
  8. Placzek, M., Fromel, W., Eberlein, B., Gilbertz, K. P., and Przybilla, B. Evaluation of phototoxic properties of fragrances. Acta Derm.Venereol. 2007;87(4):312-316. PubMed
  9. Mollace, V., Sacco, I., Janda, E., Malara, C., Ventrice, D., Colica, C., Visalli, V., Muscoli, S., Ragusa, S., Muscoli, C., Rotiroti, D., and Romeo, F. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. F PubMed
  10. Morliere, P., Huppe, G., Averbeck, D., Young, A. R., Santus, R., and Dubertret, L. In vitro photostability and photosensitizing properties of bergamot oil. Effects of a cinnamate sunscreen. J.Photochem.Photobiol.B 1990;7(2-4):199-208. PubMed
  11. Young, A. R., Walker, S. L., Kinley, J. S., Plastow, S. R., Averbeck, D., Morliere, P., and Dubertret, L. Phototumorigenesis studies of 5-methoxypsoralen in bergamot oil: evaluation and modification of risk of human use in an albino mouse skin model. J.P PubMed
  12. Girard, J., Unkovic, J., Delahayes, J., and Lafille, C. [Phototoxicity of Bergamot oil. Comparison between humans and guinea pigs]. Dermatologica 1979;158(4):229-243.
  13. Zaynoun, S. T., Johnson, B. E., and Frain-Bell, W. A study of oil of bergamot and its importance as a phototoxic agent. II. Factors which affect the phototoxic reaction induced by bergamot oil and psoralen derivatives. Contact Dermatitis 1977;3(5):225-23 PubMed
  14. Zacher, K. D. and Ippen, H. [Contact dermatitis caused by bergamot oil]. Derm.Beruf.Umwelt. 1984;32(3):95-97.
  15. Yasui, Y. and Hirone, T. Action spectrum for bergamot-oil phototoxicity measured by sunburn cell counting. J.Dermatol. 1994;21(5):319-322. PubMed
  16. Zaynoun, S. T., Johnson, B. E., and Frain-Bell, W. A study of oil of bergamot and its importance as a phototoxic agent. I. Characterization and quantification of the photoactive component. Br.J.Dermatol. 1977;96(5):475-482. PubMed
  17. Bruno A, Pandolfo G, Crucitti M, Cedro C, Zoccali RA, Muscatello MRA. Bergamot Polyphenolic Fraction Supplementation Improves Cognitive Functioning in Schizophrenia: Data From an 8-Week, Open-Label Pilot Study. J Clin Psychopharmacol 2017;37(4):468-71. PubMed

See these in context on the Bergamot monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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