Major interaction on record — check this product against your medications before combining. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Gallbladder Enzymes Ingredients & Drug Interactions

by Dr. Mercola

Gallbladder Enzymes label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gallbladder Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Gallbladder Enzymes is a dietary supplement by Dr. Mercola with 5 active ingredients. Its ingredients are commonly taken for energy and cellular function support, athletic performance and muscle energy, circulation support.Based on those ingredients, 47 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Adenosine Triphosphate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gallbladder Enzymes by Dr. Mercola

Ask about any prescription or over-the-counter medication and we check it for interactions with Gallbladder Enzymes by Dr. Mercola — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gallbladder Enzymes by Dr. Mercola

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “Pancrelipase” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Gallbladder Enzymes contains 5 active ingredients: adenosine triphosphate, pancreatic amylase, pancreatic protease, pancreatic lipase, and ox bile. The pancreatic enzymes—amylase, protease, and lipase—are digestive enzymes that help break down carbohydrates, proteins, and fats in food.

Adenosine triphosphate is a molecule involved in cellular energy, while ox bile aids fat digestion and absorption. The product also contains inactive ingredients including rice husk, hydroxypropyl methylcellulose, pectin, and medium chain triglyceride, which serve as capsule material and fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Digestive enzyme support for fat digestion.
  • We looked for evidence on: Dyspepsia, Fat malabsorption, Pancreatic insufficiency, Post-prandial bloating.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence we hold shows adenosine is effective for paroxysmal supraventricular tachycardia (a heart rhythm disorder) and for cardiovascular disease diagnosis — but that's based on its use as a prescription injectable given by medical professionals, not as an oral supplement. For the pancreatic enzymes in this product, the data shows insufficient evidence to rate their effectiveness for inflammatory bowel disease or indigestion.

The supplement form and dosages used here aren't well established in the studies we have.

The evidence, ingredient by ingredient Adenosine Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Adenosine triphosphate as an oral supplement has limited safety information — the prescription injectable form is powerful and must only be given by doctors. Safety data for breastfeeding is not established, so the product should be avoided if you're nursing.

For the pancreatic enzymes: protease and lipase are generally well tolerated in adults, though digestive upset or allergic reactions can occur. Protease exposure (especially airborne) has rarely triggered allergic rhinitis or asthma.

There is little safety data for these enzymes during pregnancy or breastfeeding, so medical guidance is advised. If you have serious digestive conditions, check with your doctor before use.

Side effects, ingredient by ingredient Adenosine Proteolytic Enzymes (proteases) Lipase

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Adenosine.
  • The most serious interaction on file is rated Major.
  • For scale: 47 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take dipyridamole (Persantine) for cardiac stress testing, do not use this product without stopping it several days beforehand — this is a major interaction. Check with your pharmacist if you take carbamazepine (Tegretol) for seizures or mood, and avoid caffeine supplements or high-dose caffeine for 24 hours around any cardiac adenosine test.

Your pharmacist can check your exact medications against this product's ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product is aimed at digestive and gallbladder support through pancreatic enzymes and bile, but the evidence for its effectiveness in supplement form isn't well established in our data. The key concern is adenosine triphosphate and its interactions with cardiac medications and caffeine.

If you take dipyridamole, carbamazepine, or use caffeine regularly, talk to your pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gallbladder Enzymes, straight from the product label.

Brand Dr. Mercola
Barcode (UPC) 810487030953
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 327116
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gallbladder Enzymes by Dr. Mercola, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
810487030953
IngredientAmount% DV
Adenosine Triphosphate0 NP--
Amylase, Pancreatic0 NP--
Protease, Pancreatic0 NP--
Lipase, Pancreatic0 NP--
Pancrelipase0 NP--
Ox Bile200 mg--

Other ingredients: Rice Husk, Hydroxypropyl Methylcellulose, Pectin, Medium Chain Triglyceride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Adults, as a dietary supplement, take one (1) capsule daily before your biggest meal. For best results, take with Dr. Mercola's Full Spectrum Enzymes.

Precautions

Keep out of reach of children.

Do not use if safety seal is broken.

If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.

Formulation

Delayed release

FDA Statement of Identity

Dietary Supplement

General Statements

Providing quality products since 2001.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gallbladder Enzymes by Dr. Mercola label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gallbladder Enzymes label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gallbladder Enzymes by Dr. Mercola

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Adenosine Triphosphate

Interacts with
47 drugs
0 NP per serving

Adenosine is a natural building block your body uses for energy and cell signaling, and a prescription injectable version is used by doctors to treat...

Adenosine Triphosphate monograph & interactions

Pancrelipase

0 NP per serving

Ox Bile

200 mg per serving

Other (inactive) ingredients: Rice Husk, Hydroxypropyl Methylcellulose, Pectin, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gallbladder Enzymes by Dr. Mercola Drug Interactions

Want to check YOUR meds against Gallbladder Enzymes?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
47Drugs
2 Major 1 Moderate 44 Minor

Ingredients driving the most interactions

Adenosine Triphosphate 47

Individual Drug Interactions

The ingredients in Gallbladder Enzymes interact with 47 drugs. Click any drug to see the details.

1 of the 5 ingredients in Gallbladder Enzymes interact with drugs. Each result below shows which ingredient is responsible. Adenosine Triphosphate

Each ingredient & the kinds of drugs it affects

For each ingredient in Gallbladder Enzymes with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Adenosine Triphosphate3 drug types · 47 drugs

Dipyridamole (Persantine)

Dipyridamole can increase the therapeutic and toxic effects of adenosine.
Dipyridamole decreases the metabolism of adenosine. Intravenous infusion of adenosine in patients who are taking dipyridamole can cause dizziness, bradycardia, and syncope. Dipyridamole should be discontinued for several days prior to a cardiac stress test using adenosine.

Likelihood Likely Evidence D
Carbamazepine (Tegretol)

Carbamazepine might increase the risk of heart block when used concomitantly with adenosine.
Carbamazepine and adenosine can both cause heart block. Giving them concurrently might produce an additive effect.

Likelihood Possible Evidence D
Methylxanthines

Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
The methylxanthines, aminophylline, caffeine, and theophylline, can block the effects of adenosine by acting as competitive antagonists at adenosine cell surface receptors. It is recommended that methylxanthines be avoided for 24 hours prior to cardiac stress tests.

Likelihood Possible Evidence D
Adenosine Triphosphate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gallbladder Enzymes, from the product label.

Dr. Mercola

See all Dr. Mercola products
Name
NHP
Street Address
125 SW 3rd Place
City
Cape Coral
State
FL
ZipCode
33991
Phone Number
(877) 985-2696
Pharmacist Counseling Corner

Gallbladder Enzymes by Dr. Mercola: Common Questions

Does Gallbladder Enzymes by Dr. Mercola interact with any medications?
Yes. Based on its ingredients, Gallbladder Enzymes has a known interaction with 47 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gallbladder Enzymes contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
The safety data we have is not sufficient to say yes or no. The product contains ingredients whose safety in pregnancy has not been well established. Talk with your doctor or pharmacist about your individual situation before using it.
Can I take this while breastfeeding?
Safety while breastfeeding has not been established for most of these ingredients. The adenosine component specifically should be avoided. Check with your healthcare provider first.
What are the pancreatic enzymes in this product supposed to do?
Amylase, protease, and lipase are digestive enzymes that help break down carbohydrates, proteins, and fats in your food so your body can absorb them better. They're designed to support digestive function.
Are there any side effects from the digestive enzymes?
The pancreatic enzymes are generally well tolerated, but some people may experience digestive upset or allergic reactions. Allergic responses to protease are rare but have been reported, especially with airborne exposure.
Is it safe if I drink a lot of coffee?
Caffeine can block the effects of adenosine in this product. If you take this around the time of a cardiac adenosine stress test, you should avoid caffeine for 24 hours beforehand — talk to your doctor about timing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gallbladder Enzymes is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gallbladder Enzymes label
Go deeper

The Full Monographs Behind Gallbladder Enzymes’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Adenosine

Interacts with 47 drugs

Adenosine is a natural building block your body uses for energy and cell signaling, and a prescription injectable version is used by doctors to treat certain fast heart rhythms. As an over-t...

Read the full Adenosine monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph →
Sources

Sources & How We Checked

Gallbladder Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Adenosine 10 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Agteresch HJ, Dagnelie PC, van den Berg JW, Wilson JH. Adenosine triphosphate: established and potential clinical applications. Drugs 1999;58:211-32.. PubMed
  3. Agteresch HJ, Dagnelie PC, van der Gaast A, et al. Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 2000;92:321-8.. PubMed
  4. Haskell CM, Wong M, Williams A, Lee LY. Phase I trial of extracellular adenosine 5'-triphosphate in patients with advanced cancer. Med Pediatr Oncol 1996;27:165-73.. DOI
  5. Haskell CM, Mendoza E, Pisters KM, et al. Phase II study of intravenous adenosine 5'-triphosphate in patients with previously untreated stage IIIB and stage IV non-small cell lung cancer. Invest New Drugs 1998;16:81-5.. PubMed
  6. Eisenach JC, Curry R, Hood DD. Dose response of intrathecal adenosine in experimental pain and allodynia. Anesthesiology 2002;97:938-42.. PubMed
  7. Agteresch HJ, Dagnelie PC, Rietveld T, et al. Pharmacokinetics of intravenous ATP in cancer patients. Eur J Clin Pharmacol 2000;56:49-55.. PubMed
  8. Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50. PubMed
  9. Litmann L, Anderson JD, Monroe MH. Adenosine and Aggrenox: A hazardous combination. Ann Intern Med 2002;137:E-76. PubMed
  10. Faghihi G, Iraji F, Rajaee Harandi M, et al. Comparison of the efficacy of topical minoxidil 5% and adenosine 0.75% solutions on male androgenic alopecia and measuring patient satisfaction rate. Acta Dermatovenerol Croat 2013;21(3):155-9.

See these in context on the Adenosine monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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