Adenosine - Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine Interaction
Herbal: Adenosine
Also Known As: Adenosine, Adenosine Monophosphate (AMP), Adenosine-5-monophosphate (A5MP), Adenosine Diphosphate (ADP), Adenosine Triphosphate (ATP)
Drug: Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine
Brand names:
Hycomine Compound
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine is classified as belonging to the following category: Methylxanthines
Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
The methylxanthines, aminophylline, caffeine, and theophylline, can block the effects of adenosine by acting as competitive antagonists at adenosine cell surface receptors. It is recommended that methylxanthines be avoided for 24 hours prior to cardiac stress tests.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Eisenach JC, Curry R, Hood DD. Dose response of intrathecal adenosine in experimental pain and allodynia. Anesthesiology 2002;97:938-42..
- Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50.
Adenosine Overview
Adenosine, a purine nucleoside, is naturally present in all human cells. The US Food and Drug Administration has approved an injectable form of adenosine as a prescription medication. Adenosine's monophosphate and triphosphate salt forms are occasionally included in supplement products. In supplements, these forms of adenosine are typically used to support energy production and other cellular functions.
Adenosine - More Interactions
Adenosine interacts with 47 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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