Common Stonecrop Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Common Stonecrop interacts with medications. The heart of this page is the interaction list — every drug Common Stonecrop is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Common Stonecrop is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Common Stonecrop against your medication
Add one medicationDrugs that interact with Common Stonecrop
0 medications have a known interaction with Common Stonecrop, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Common Stonecrop. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Common Stonecrop combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Common Stonecrop: Uses, Safety & Side Effects
Common Stonecrop (Sedum acre) is a small succulent with a long history in European folk medicine, mostly applied to the skin or used as a laxative. There is very little modern scientific evidence to support any of its uses, and the plant can be irritating and may cause vomiting or diarrhea when swallowed, so it should be used with caution and ideally avoided internally.

- Scientific name
- Sedum acre
- Family
- Crassulaceae
- Part used
- Above-ground parts (leaves, stems, and flowering tops), used fresh or dried
- Common forms
- Fresh plant, dried herb, topical preparations, and rarely teas or tinctures
- Wounds and skin irritation
- Eczema and other skin conditions
- Constipation (laxative use)
- Urinary and bladder complaints
- High blood pressure (folk use)
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Limited safety data exist, and internal use can cause irritation, vomiting, and diarrhea.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Common Stonecrop is a small, low-growing succulent plant known by the scientific name Sedum acre. It has thick, fleshy green leaves and bright yellow, star-shaped flowers that bloom in summer. It is sometimes called Gold Chain, Golden Moss, Wall Pepper, or Biting Stonecrop because of its sharp, peppery taste.
The plant is native to Europe and parts of Asia and North Africa, and it has spread to North America, where it is often grown as a ground cover or rock-garden plant. It thrives in rocky, sandy, and dry soils where many other plants struggle.
In traditional European folk medicine, people have used Common Stonecrop mainly on the skin for wounds and rashes, and sometimes internally as a laxative or for urinary complaints. Today it is far more common as an ornamental plant than as a medicine.
How it works
Common Stonecrop contains a mix of natural compounds, including alkaloids, flavonoids, tannins, and other plant chemicals. Tannins are astringent, which may help explain its traditional use on wounds and irritated skin.
Some of the plant's alkaloids are thought to be responsible for its sharp taste and its irritating effect on the digestive tract, which could account for its laxative and vomiting-causing properties when swallowed.
It is important to understand that these proposed mechanisms are based mostly on laboratory analysis and animal research, not on well-designed human studies. We do not have clear evidence showing how, or whether, these compounds produce meaningful benefits in people.
Does Common Stonecrop work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Common Stonecrop, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 4 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Cough
Although there has been interest in using oral common stonecrop for cough, there is insufficient reliable information about the clinical effects of common stonecrop for this purpose.
Insufficient Reliable Evidence To Rate Hypertension
Although there has been interest in using oral common stonecrop for hypertension, there is insufficient reliable information about the clinical effects of common stonecrop for this purpose.
Insufficient Reliable Evidence To Rate Warts
Although there has been interest in using topical common stonecrop for warts, there is insufficient reliable information about the clinical effects of common stonecrop for this purpose.
Insufficient Reliable Evidence To Rate Wound healing
Although there has been interest in using topical common stonecrop for wound healing, there is insufficient reliable information about the clinical effects of common stonecrop for this purpose.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
Common Stonecrop is not well studied for safety. When eaten, it has a sharp, peppery taste and can irritate the mouth and stomach, and larger amounts may cause vomiting and diarrhea. For this reason, internal use should be approached with great caution.
Applied to the skin, it may cause irritation in some people. If you have sensitive skin or allergies, do a small test on a small patch of skin first, and stop if you notice redness, itching, or burning.
Pregnancy and breastfeeding: There is not enough information to consider Common Stonecrop safe during pregnancy or while breastfeeding. Because it can affect the digestive tract and its effects are poorly understood, it is best to avoid it during these times.
Children, older adults, and people with kidney, stomach, or bowel conditions should be especially careful and should talk to a pharmacist or doctor before using it. Never assume a plant is safe just because it is natural.
Side effects
The most likely side effects come from swallowing the plant. These can include nausea, vomiting, stomach cramps, and diarrhea, partly because of the plant's irritating compounds.
Used on the skin, it may cause local irritation, redness, or an allergic reaction in some people.
Because safety information is limited, more serious reactions cannot be ruled out. Stop using it and seek medical care if you have severe stomach symptoms, trouble breathing, swelling, or signs of an allergic reaction.
Common Stonecrop: Reported Adverse Effects
Documented safety reports on Common Stonecrop from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
Reports by conditionDiarrhea Gastrointestinal
Orally, common stonecrop can cause vomiting and diarrhea when consumed in very large amounts.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no established or standardized dose for Common Stonecrop. Because it has not been studied in proper clinical trials, safe and effective amounts are simply not known.
If you choose to use a commercial product, follow the directions on the label and do not exceed them. Given the lack of safety data and the plant's irritating effects, internal use is generally not recommended.
Always talk with a pharmacist or doctor before using Common Stonecrop, especially if you take other medicines, have a health condition, or are pregnant or breastfeeding.
Common Stonecrop & Pregnancy
Common Stonecrop & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 1 references that drive our Common Stonecrop monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Common Stonecrop: Common Questions
What is Common Stonecrop used for, and does it work?
Does Common Stonecrop interact with prescription medications?
How are Common Stonecrop interactions rated?
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Where does this Common Stonecrop interaction information come from?
What is Common Stonecrop used for?
Is Common Stonecrop safe to eat?
Can I use Common Stonecrop if I'm pregnant or breastfeeding?
Is the same plant grown in gardens safe to use as medicine?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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