Herb & supplement monograph

Common Stonecrop Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Common Stonecrop

0 medications have a known interaction with Common Stonecrop, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Common Stonecrop. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Common Stonecrop combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Common Stonecrop: Uses, Safety & Side Effects

The bottom line

Common Stonecrop (Sedum acre) is a small succulent with a long history in European folk medicine, mostly applied to the skin or used as a laxative. There is very little modern scientific evidence to support any of its uses, and the plant can be irritating and may cause vomiting or diarrhea when swallowed, so it should be used with caution and ideally avoided internally.

Common Stonecrop
Scientific name
Sedum acre
Family
Crassulaceae
Part used
Above-ground parts (leaves, stems, and flowering tops), used fresh or dried
Common forms
Fresh plant, dried herb, topical preparations, and rarely teas or tinctures
People commonly use it for
  • Wounds and skin irritation
  • Eczema and other skin conditions
  • Constipation (laxative use)
  • Urinary and bladder complaints
  • High blood pressure (folk use)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Limited safety data exist, and internal use can cause irritation, vomiting, and diarrhea.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Common Stonecrop is a small, low-growing succulent plant known by the scientific name Sedum acre. It has thick, fleshy green leaves and bright yellow, star-shaped flowers that bloom in summer. It is sometimes called Gold Chain, Golden Moss, Wall Pepper, or Biting Stonecrop because of its sharp, peppery taste.

The plant is native to Europe and parts of Asia and North Africa, and it has spread to North America, where it is often grown as a ground cover or rock-garden plant. It thrives in rocky, sandy, and dry soils where many other plants struggle.

In traditional European folk medicine, people have used Common Stonecrop mainly on the skin for wounds and rashes, and sometimes internally as a laxative or for urinary complaints. Today it is far more common as an ornamental plant than as a medicine.

How it works

Common Stonecrop contains a mix of natural compounds, including alkaloids, flavonoids, tannins, and other plant chemicals. Tannins are astringent, which may help explain its traditional use on wounds and irritated skin.

Some of the plant's alkaloids are thought to be responsible for its sharp taste and its irritating effect on the digestive tract, which could account for its laxative and vomiting-causing properties when swallowed.

It is important to understand that these proposed mechanisms are based mostly on laboratory analysis and animal research, not on well-designed human studies. We do not have clear evidence showing how, or whether, these compounds produce meaningful benefits in people.

Effectiveness

Does Common Stonecrop work?

Evidence overview · 4 uses evaluated
4 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Common Stonecrop, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 4 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Cough
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral common stonecrop for cough, there is insufficient reliable information about the clinical effects of common stonecrop for this purpose.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral common stonecrop for hypertension, there is insufficient reliable information about the clinical effects of common stonecrop for this purpose.

Insufficient Reliable Evidence To Rate Warts
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical common stonecrop for warts, there is insufficient reliable information about the clinical effects of common stonecrop for this purpose.

Insufficient Reliable Evidence To Rate Wound healing
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical common stonecrop for wound healing, there is insufficient reliable information about the clinical effects of common stonecrop for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Common Stonecrop is not well studied for safety. When eaten, it has a sharp, peppery taste and can irritate the mouth and stomach, and larger amounts may cause vomiting and diarrhea. For this reason, internal use should be approached with great caution.

Applied to the skin, it may cause irritation in some people. If you have sensitive skin or allergies, do a small test on a small patch of skin first, and stop if you notice redness, itching, or burning.

Pregnancy and breastfeeding: There is not enough information to consider Common Stonecrop safe during pregnancy or while breastfeeding. Because it can affect the digestive tract and its effects are poorly understood, it is best to avoid it during these times.

Children, older adults, and people with kidney, stomach, or bowel conditions should be especially careful and should talk to a pharmacist or doctor before using it. Never assume a plant is safe just because it is natural.

Side effects

The most likely side effects come from swallowing the plant. These can include nausea, vomiting, stomach cramps, and diarrhea, partly because of the plant's irritating compounds.

Used on the skin, it may cause local irritation, redness, or an allergic reaction in some people.

Because safety information is limited, more serious reactions cannot be ruled out. Stop using it and seek medical care if you have severe stomach symptoms, trouble breathing, swelling, or signs of an allergic reaction.

Common Stonecrop: Reported Adverse Effects

Documented safety reports on Common Stonecrop from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Diarrhea Gastrointestinal

Orally, common stonecrop can cause vomiting and diarrhea when consumed in very large amounts.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no established or standardized dose for Common Stonecrop. Because it has not been studied in proper clinical trials, safe and effective amounts are simply not known.

If you choose to use a commercial product, follow the directions on the label and do not exceed them. Given the lack of safety data and the plant's irritating effects, internal use is generally not recommended.

Always talk with a pharmacist or doctor before using Common Stonecrop, especially if you take other medicines, have a health condition, or are pregnant or breastfeeding.

Pregnancy & Breastfeeding

Common Stonecrop & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Common Stonecrop & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 references that drive our Common Stonecrop monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Common Stonecrop: Common Questions

What is Common Stonecrop used for, and does it work?
People use Common Stonecrop for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Common Stonecrop interact with prescription medications?
We do not currently list any known drug interactions for Common Stonecrop. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Common Stonecrop interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Common Stonecrop with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Common Stonecrop interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Common Stonecrop used for?
Traditionally it has been used on the skin for wounds and rashes, and internally as a laxative or for urinary complaints. However, there is very little modern evidence that it works for any of these uses.
Is Common Stonecrop safe to eat?
It has a sharp, peppery taste and can irritate the stomach and bowels, and larger amounts may cause vomiting and diarrhea. Because of these effects and limited safety data, internal use is best avoided.
Can I use Common Stonecrop if I'm pregnant or breastfeeding?
No. There is not enough safety information, so it is best to avoid it during pregnancy and breastfeeding.
Is the same plant grown in gardens safe to use as medicine?
Common Stonecrop is widely grown as an ornamental ground cover, but being a garden plant does not make it safe to consume. Talk to a pharmacist or doctor before using any plant medicinally.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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